SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 GLY A 139
GLN A 141
VAL A 246
SER A 250
 None
 1.33A 1p6kB-5u5iA:
undetectable		 1p6kB-5u5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 GLY A 139
GLN A 141
VAL A 246
SER A 250
 None
 1.35A 1zzuB-5u5iA:
undetectable		 1zzuB-5u5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 HIS A 244
ALA A 225
GLU A 169
HIS A 227
 None
 1.23A 3mbgB-5u5iA:
undetectable
3mbgC-5u5iA:
undetectable		 3mbgB-5u5iA:
undetectable
3mbgC-5u5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 GLU A 169
HIS A 227
HIS A 244
ALA A 225
 None
 1.23A 3mbgB-5u5iA:
undetectable
3mbgC-5u5iA:
undetectable		 3mbgB-5u5iA:
undetectable
3mbgC-5u5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZNC_A_BZ1A500_1
(CARBONIC ANHYDRASE
IV)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		5 / 10 HIS A 244
HIS A 227
VAL A 167
LEU A 183
THR A 181
 None
 1.47A 3zncA-5u5iA:
undetectable		 3zncA-5u5iA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		5 / 11 HIS A 244
HIS A 227
VAL A 167
LEU A 165
THR A 181
 None
 1.00A 4lu3A-5u5iA:
undetectable		 4lu3A-5u5iA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 THR A  90
THR A 113
ASP A  88
TYR A 102
 NAD  A 301 (-4.0A)
NAD  A 301 (-4.2A)
None
None
 1.22A 4oltA-5u5iA:
undetectable		 4oltA-5u5iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 THR A  90
THR A 113
ASP A  88
TYR A 102
 NAD  A 301 (-4.0A)
NAD  A 301 (-4.2A)
None
None
 1.23A 4oltB-5u5iA:
undetectable		 4oltB-5u5iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 THR A  90
THR A 113
ASP A  88
TYR A 102
 NAD  A 301 (-4.0A)
NAD  A 301 (-4.2A)
None
None
 1.23A 4qwpA-5u5iA:
undetectable		 4qwpA-5u5iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 7 THR A  46
LEU A  45
THR A  90
VAL A  86
 NAD  A 301 (-4.7A)
NAD  A 301 (-4.9A)
NAD  A 301 (-4.0A)
None
 1.09A 5ov9A-5u5iA:
3.3		 5ov9A-5u5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5u5i HTPA REDUCTASE
(Selaginella
moellendorffii) 		4 / 5 GLN A 172
THR A 181
HIS A 244
GLY A 223
 None
 1.22A 6gbnC-5u5iA:
8.2		 6gbnC-5u5iA:
11.76