SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 11 GLY A 150
LEU A 221
ILE A 200
HIS A 176
ALA A 162
 None
None
None
ACT  A 406 ( 4.0A)
None
 1.31A 2a58A-5u63A:
5.4
2a58E-5u63A:
5.3		 2a58A-5u63A:
21.88
2a58E-5u63A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 200
HIS A 176
ALA A 162
GLY A 150
LEU A 221
 None
ACT  A 406 ( 4.0A)
None
None
None
 1.30A 2a58A-5u63A:
5.3
2a58B-5u63A:
5.4		 2a58A-5u63A:
21.88
2a58B-5u63A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 200
HIS A 176
ALA A 162
GLY A 150
LEU A 221
 None
ACT  A 406 ( 4.0A)
None
None
None
 1.30A 2a58B-5u63A:
5.4
2a58C-5u63A:
5.4		 2a58B-5u63A:
21.88
2a58C-5u63A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 11 ILE A 200
HIS A 176
ALA A 162
GLY A 150
LEU A 221
 None
ACT  A 406 ( 4.0A)
None
None
None
 1.31A 2a58C-5u63A:
5.3
2a58D-5u63A:
5.3		 2a58C-5u63A:
21.88
2a58D-5u63A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 200
HIS A 176
ALA A 162
GLY A 150
LEU A 221
 None
ACT  A 406 ( 4.0A)
None
None
None
 1.29A 2a58D-5u63A:
5.3
2a58E-5u63A:
5.3		 2a58D-5u63A:
21.88
2a58E-5u63A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		3 / 3 SER A 134
THR A  45
GLN A  39
 None
 0.79A 2fk8A-5u63A:
undetectable		 2fk8A-5u63A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		4 / 4 LEU A 239
ILE A 120
ILE A 243
ALA A 242
 None
NAP  A 407 ( 4.6A)
NAP  A 407 (-3.6A)
None
 0.86A 2i30A-5u63A:
undetectable		 2i30A-5u63A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 401 (-3.1A)
None
FAD  A 401 (-3.4A)
 0.94A 2yvlA-5u63A:
4.6		 2yvlA-5u63A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 401 (-3.1A)
None
FAD  A 401 (-3.4A)
 0.95A 2yvlB-5u63A:
4.6		 2yvlB-5u63A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 111
ILE A 110
GLY A 285
ALA A 283
ALA A 295
 None
None
FAD  A 401 (-3.1A)
None
FAD  A 401 (-3.4A)
 0.95A 2yvlC-5u63A:
4.3		 2yvlC-5u63A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ILE A 111
ALA A 284
ALA A  17
VAL A  88
ILE A 251
 None
None
FAD  A 401 (-3.4A)
None
FAD  A 401 ( 4.8A)
 1.07A 3e00A-5u63A:
undetectable		 3e00A-5u63A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 11 HIS A 245
ALA A 295
LEU A  44
THR A  46
THR A  47
 FAD  A 401 ( 3.9A)
FAD  A 401 (-3.4A)
FAD  A 401 (-3.9A)
None
FAD  A 401 (-3.7A)
 1.23A 3mdzA-5u63A:
undetectable		 3mdzA-5u63A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		4 / 8 GLN A  39
GLY A  42
GLY A 244
ASN A 156
 None
FAD  A 401 (-3.3A)
NAP  A 407 (-3.2A)
None
 0.91A 3v3nB-5u63A:
9.2		 3v3nB-5u63A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		4 / 8 GLN A  39
GLY A  42
GLY A 244
ASN A 156
 None
FAD  A 401 (-3.3A)
NAP  A 407 (-3.2A)
None
 0.91A 3v3nC-5u63A:
9.2		 3v3nC-5u63A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 11 GLY A 285
GLY A 114
ILE A 111
ASP A 286
PRO A  16
 FAD  A 401 (-3.1A)
FAD  A 401 (-3.2A)
None
FAD  A 401 (-2.9A)
FAD  A 401 (-3.7A)
 1.15A 4dcmA-5u63A:
2.7		 4dcmA-5u63A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 TYR A 192
LEU A 202
ALA A 242
ALA A 162
VAL A 151
 None
 0.95A 4hfpD-5u63A:
undetectable		 4hfpD-5u63A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 LEU A 223
LEU A 208
ILE A 175
GLY A 220
LEU A 234
 None
 0.86A 4lmnA-5u63A:
undetectable		 4lmnA-5u63A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		4 / 8 ALA A 284
GLY A 302
ALA A  21
GLY A  18
 None
 0.65A 4zjzA-5u63A:
undetectable		 4zjzA-5u63A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 GLN A 255
LEU A 256
LEU A  97
THR A 113
ILE A 111
 None
None
None
FAD  A 401 (-4.2A)
None
 1.28A 5b8hA-5u63A:
undetectable
5b8hB-5u63A:
undetectable		 5b8hA-5u63A:
24.07
5b8hB-5u63A:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		3 / 3 GLY A  37
LEU A  38
HIS A  84
 FAD  A 401 ( 3.1A)
ACT  A 405 ( 3.6A)
ACT  A 405 ( 3.9A)
 0.05A 5u63A-5u63A:
53.2		 5u63A-5u63A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		3 / 3 HIS A 176
SER A 180
ARG A 182
 ACT  A 406 ( 4.0A)
ACT  A 406 (-3.9A)
NAP  A 407 ( 3.1A)
 0.02A 5u63A-5u63A:
53.2		 5u63A-5u63A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		3 / 3 GLY A  37
LEU A  38
HIS A  84
 FAD  A 401 ( 3.1A)
ACT  A 405 ( 3.6A)
ACT  A 405 ( 3.9A)
 0.10A 5u63B-5u63A:
50.4		 5u63B-5u63A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ARG A 118
GLY A 244
VAL A 211
LEU A 221
ILE A 120
 NAP  A 407 (-3.8A)
NAP  A 407 (-3.2A)
None
None
NAP  A 407 ( 4.6A)
 1.18A 5vooC-5u63A:
undetectable		 5vooC-5u63A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 ALA A   7
GLY A  18
ALA A  22
VAL A  35
THR A  78
 None
 0.99A 5w4zB-5u63A:
undetectable		 5w4zB-5u63A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 LEU A 239
ILE A 175
ILE A 188
TYR A 192
LEU A 191
 None
 1.09A 5y2tB-5u63A:
undetectable		 5y2tB-5u63A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 12 LEU A 239
ILE A 175
GLY A 153
TYR A 192
LEU A 191
 None
None
NAP  A 407 ( 4.1A)
None
None
 0.94A 5ycnA-5u63A:
undetectable		 5ycnA-5u63A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		3 / 3 ARG A 118
ARG A 182
ARG A 177
 NAP  A 407 (-3.8A)
NAP  A 407 ( 3.1A)
NAP  A 407 ( 3.5A)
 0.81A 6bplA-5u63A:
undetectable
6bplB-5u63A:
undetectable		 6bplA-5u63A:
16.67
6bplB-5u63A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5u63 THIOREDOXIN
REDUCTASE
(Haemophilus
influenzae) 		5 / 9 VAL A 281
VAL A 287
LEU A 109
GLY A  13
LEU A  12
 None
None
None
FAD  A 401 (-3.2A)
FAD  A 401 ( 4.9A)
 1.35A 6czmD-5u63A:
undetectable
6czmE-5u63A:
undetectable		 6czmD-5u63A:
22.73
6czmE-5u63A:
22.73