SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5u68 MPE8
(Homo
sapiens) 		7 / 12 TYR E 201
GLN E 254
PHE E 264
ASN E  54
VAL E  56
ALA E 116
TRP E 133
 None
 0.76A 1h8sA-5u68E:
21.5		 1h8sA-5u68E:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 5u68 MPE8
(Homo
sapiens) 		4 / 4 ALA E 111
ARG E  57
GLN E  58
GLU E  65
 None
 1.40A 1lqtB-5u68E:
undetectable		 1lqtB-5u68E:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 5u68 MPE8
(Homo
sapiens) 		4 / 4 ALA E 111
ARG E  57
GLN E  58
GLU E  65
 None
 1.38A 1lquB-5u68E:
undetectable		 1lquB-5u68E:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5u68 MPE8
(Homo
sapiens) 		5 / 12 GLY E 262
ALA E  80
PHE E 264
LEU E  64
PHE E 130
 None
 1.08A 1nw3A-5u68E:
undetectable		 1nw3A-5u68E:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5u68 MPE8
(Homo
sapiens) 		4 / 7 TYR E 201
PRO E 209
TYR E 252
TYR E 114
 None
 0.70A 2oldA-5u68E:
18.9
2oldB-5u68E:
18.8		 2oldA-5u68E:
24.09
2oldB-5u68E:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5u68 MPE8
(Homo
sapiens) 		5 / 11 VAL E  21
ALA E  43
MET E  53
ARG E  91
ASN E  93
 None
 0.80A 3qxvC-5u68E:
21.0		 3qxvC-5u68E:
61.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5u68 MPE8
(Homo
sapiens) 		4 / 7 THR E 241
ALA E 239
SER E 184
THR E 182
 None
 0.75A 4pwjB-5u68E:
undetectable		 4pwjB-5u68E:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5u68 MPE8
(Homo
sapiens) 		4 / 5 VAL E 181
ILE E 183
VAL E 270
THR E 268
 None
 0.77A 4xdtA-5u68E:
undetectable		 4xdtA-5u68E:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5u68 MPE8
(Homo
sapiens) 		3 / 3 THR E  47
SER E  50
TYR E  51
 None
 0.80A 5jsdA-5u68E:
undetectable		 5jsdA-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5u68 MPE8
(Homo
sapiens) 		3 / 3 THR E  47
SER E  50
TYR E  51
 None
 0.80A 5jsdB-5u68E:
undetectable		 5jsdB-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5u68 MPE8
(Homo
sapiens) 		3 / 3 THR E  47
SER E  50
TYR E  51
 None
 0.80A 5jsdC-5u68E:
undetectable		 5jsdC-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5u68 MPE8
(Homo
sapiens) 		3 / 3 THR E  47
SER E  50
TYR E  51
 None
 0.82A 5jseA-5u68E:
undetectable		 5jseA-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5u68 MPE8
(Homo
sapiens) 		3 / 3 THR E  47
SER E  50
TYR E  51
 None
 0.81A 5jseB-5u68E:
undetectable		 5jseB-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5u68 MPE8
(Homo
sapiens) 		3 / 3 THR E  47
SER E  50
TYR E  51
 None
 0.81A 5jseC-5u68E:
undetectable		 5jseC-5u68E:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEH_A_RPTA601_1
(SCAFFOLD PROTEIN D13)		 5u68 MPE8
(Homo
sapiens) 		5 / 10 PRO E 128
SER E  69
VAL E  56
PHE E 130
PHE E 264
 None
 1.18A 6behA-5u68E:
2.7
6behB-5u68E:
undetectable
6behC-5u68E:
1.8		 6behA-5u68E:
19.21
6behB-5u68E:
19.21
6behC-5u68E:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5u68 MPE8
(Homo
sapiens) 		5 / 9 ARG E  57
ALA E 107
VAL E 141
SER E 142
ASP E 109
 None
 1.35A 6c2mB-5u68E:
undetectable		 6c2mB-5u68E:
14.19