SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Mus
musculus) 		5 / 12 ASP A 624
LEU A 601
GLY A 661
THR A 617
LEU A 636
 None
 0.98A 1liiA-5u6kA:
undetectable		 1liiA-5u6kA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Mus
musculus) 		3 / 3 TYR A 708
VAL A 741
THR A 704
 None
 0.87A 2ygnA-5u6kA:
undetectable		 2ygnA-5u6kA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Mus
musculus) 		5 / 12 ILE A 585
ILE A 578
VAL A 599
VAL A 614
PHE A 566
 None
 1.05A 2ygoA-5u6kA:
undetectable		 2ygoA-5u6kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Mus
musculus) 		5 / 12 ILE A 585
ILE A 578
VAL A 599
VAL A 614
PHE A 566
 None
 1.05A 2ygpA-5u6kA:
undetectable		 2ygpA-5u6kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5u6k DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Mus
musculus) 		5 / 10 PHE A 561
ASP A 595
ALA A 582
SER A 560
GLY A 583
 None
 1.23A 4xp1A-5u6kA:
undetectable		 4xp1A-5u6kA:
17.96