SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ARG A 267
ILE A 176
TRP A 175
 None
 1.04A 1m8eB-5u6oA:
undetectable		 1m8eB-5u6oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ARG A 267
ILE A 176
TRP A 175
 None
 1.16A 1nodB-5u6oA:
undetectable		 1nodB-5u6oA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.31A 1nsiA-5u6oA:
undetectable
1nsiB-5u6oA:
undetectable		 1nsiA-5u6oA:
18.98
1nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.47A 1nsiA-5u6oA:
undetectable
1nsiB-5u6oA:
undetectable		 1nsiA-5u6oA:
18.98
1nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.28A 1nsiA-5u6oA:
undetectable
1nsiB-5u6oA:
undetectable		 1nsiA-5u6oA:
18.98
1nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.47A 1nsiA-5u6oA:
undetectable
1nsiB-5u6oA:
undetectable		 1nsiA-5u6oA:
18.98
1nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.32A 1nsiC-5u6oA:
undetectable
1nsiD-5u6oA:
undetectable		 1nsiC-5u6oA:
18.98
1nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.42A 1nsiC-5u6oA:
undetectable
1nsiD-5u6oA:
undetectable		 1nsiC-5u6oA:
18.98
1nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.34A 1nsiC-5u6oA:
undetectable
1nsiD-5u6oA:
undetectable		 1nsiC-5u6oA:
18.98
1nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.43A 1nsiC-5u6oA:
undetectable
1nsiD-5u6oA:
undetectable		 1nsiC-5u6oA:
18.98
1nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ARG A 267
ILE A 176
TRP A 175
 None
 1.20A 1qomA-5u6oA:
undetectable		 1qomA-5u6oA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 5 PHE A 476
PHE A 514
MET A 512
SER A 565
 None
 1.18A 1wrkB-5u6oA:
undetectable		 1wrkB-5u6oA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ASN A 107
TYR A 144
SER A 139
 None
 0.88A 2gvcB-5u6oA:
undetectable		 2gvcB-5u6oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ASN A 107
TYR A 144
SER A 139
 None
 0.90A 2gvcE-5u6oA:
undetectable		 2gvcE-5u6oA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.38A 2nsiA-5u6oA:
undetectable
2nsiB-5u6oA:
undetectable		 2nsiA-5u6oA:
18.98
2nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.45A 2nsiA-5u6oA:
undetectable
2nsiB-5u6oA:
undetectable		 2nsiA-5u6oA:
18.98
2nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.34A 2nsiA-5u6oA:
undetectable
2nsiB-5u6oA:
undetectable		 2nsiA-5u6oA:
18.98
2nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.44A 2nsiA-5u6oA:
undetectable
2nsiB-5u6oA:
undetectable		 2nsiA-5u6oA:
18.98
2nsiB-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.35A 2nsiC-5u6oA:
undetectable
2nsiD-5u6oA:
undetectable		 2nsiC-5u6oA:
18.98
2nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.43A 2nsiC-5u6oA:
undetectable
2nsiD-5u6oA:
undetectable		 2nsiC-5u6oA:
18.98
2nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.36A 2nsiC-5u6oA:
undetectable
2nsiD-5u6oA:
undetectable		 2nsiC-5u6oA:
18.98
2nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.44A 2nsiC-5u6oA:
undetectable
2nsiD-5u6oA:
undetectable		 2nsiC-5u6oA:
18.98
2nsiD-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 TYR A 435
TYR A 407
GLN A 406
ILE A 443
 None
 1.02A 2pgzD-5u6oA:
undetectable
2pgzE-5u6oA:
undetectable		 2pgzD-5u6oA:
16.04
2pgzE-5u6oA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ARG A 267
ILE A 176
TRP A 175
 None
 0.97A 3e68A-5u6oA:
undetectable		 3e68A-5u6oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		3 / 3 ARG A 267
ILE A 176
TRP A 175
 None
 1.01A 3e6tB-5u6oA:
undetectable		 3e6tB-5u6oA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.35A 3e7gA-5u6oA:
undetectable
3e7gB-5u6oA:
undetectable		 3e7gA-5u6oA:
19.32
3e7gB-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.46A 3e7gA-5u6oA:
undetectable
3e7gB-5u6oA:
undetectable		 3e7gA-5u6oA:
19.32
3e7gB-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.35A 3e7gA-5u6oA:
undetectable
3e7gB-5u6oA:
undetectable		 3e7gA-5u6oA:
19.32
3e7gB-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.47A 3e7gA-5u6oA:
undetectable
3e7gB-5u6oA:
undetectable		 3e7gA-5u6oA:
19.32
3e7gB-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.36A 3e7gC-5u6oA:
undetectable
3e7gD-5u6oA:
undetectable		 3e7gC-5u6oA:
19.32
3e7gD-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.49A 3e7gC-5u6oA:
undetectable
3e7gD-5u6oA:
undetectable		 3e7gC-5u6oA:
19.32
3e7gD-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 8 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.38A 3e7gC-5u6oA:
undetectable
3e7gD-5u6oA:
undetectable		 3e7gC-5u6oA:
19.32
3e7gD-5u6oA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 8 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.34A 4cx7A-5u6oA:
undetectable
4cx7B-5u6oA:
undetectable		 4cx7A-5u6oA:
18.98
4cx7B-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.32A 4cx7C-5u6oA:
0.0
4cx7D-5u6oA:
0.0		 4cx7C-5u6oA:
18.98
4cx7D-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.43A 4cx7C-5u6oA:
0.0
4cx7D-5u6oA:
0.0		 4cx7C-5u6oA:
18.98
4cx7D-5u6oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.31A 4nosA-5u6oA:
0.7
4nosB-5u6oA:
undetectable		 4nosA-5u6oA:
19.38
4nosB-5u6oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 278
TRP A 281
PHE A 285
GLU A 283
 None
 1.29A 4nosC-5u6oA:
undetectable
4nosD-5u6oA:
undetectable		 4nosC-5u6oA:
19.38
4nosD-5u6oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 7 ILE A 284
TRP A 281
PHE A 143
GLU A 282
 None
 1.49A 4nosC-5u6oA:
undetectable
4nosD-5u6oA:
undetectable		 4nosC-5u6oA:
19.38
4nosD-5u6oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 PHE A 285
GLU A 283
ILE A 278
TRP A 281
 None
 1.31A 4nosC-5u6oA:
undetectable
4nosD-5u6oA:
undetectable		 4nosC-5u6oA:
19.38
4nosD-5u6oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 TRP A 281
PHE A 143
GLU A 282
ILE A 284
 None
 1.41A 4nosC-5u6oA:
undetectable
4nosD-5u6oA:
undetectable		 4nosC-5u6oA:
19.38
4nosD-5u6oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 6 LEU A 301
ASN A 300
MET A 356
VAL A 154
 None
 1.16A 4okbA-5u6oA:
undetectable		 4okbA-5u6oA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		5 / 12 LEU A 357
ALA A 383
ILE A 359
GLY A 360
THR A 375
 None
 1.03A 5nfjC-5u6oA:
undetectable		 5nfjC-5u6oA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1
(Homo
sapiens) 		4 / 4 PHE A 166
LEU A 307
LEU A 349
VAL A 158
 None
 1.24A 5xxiA-5u6oA:
undetectable		 5xxiA-5u6oA:
20.80