SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ARG A 299
SER A 325
TYR A 268
LEU A 285
LEU A 277
 None
UDP  A 503 (-3.1A)
None
None
None
 1.44A 1e7wA-5u6sA:
5.4		 1e7wA-5u6sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ARG A 299
SER A 325
TYR A 268
LEU A 285
LEU A 277
 None
UDP  A 503 (-3.1A)
None
None
None
 1.44A 1p33B-5u6sA:
2.7		 1p33B-5u6sA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 10 LEU A 340
ALA A 371
VAL A 267
GLN A 363
PHE A 271
 None
 1.23A 1rlbE-5u6sA:
undetectable		 1rlbE-5u6sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 6 THR A 365
GLN A 134
PHE A 170
PHE A 113
 7WV  A 504 (-3.2A)
7WV  A 504 (-3.0A)
None
7WV  A 504 (-4.8A)
 1.46A 1tt0C-5u6sA:
2.6		 1tt0C-5u6sA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 PHE A 196
LEU A 220
VAL A 127
ALA A  10
VAL A 446
 None
 1.26A 2g70A-5u6sA:
undetectable		 2g70A-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 PHE A 196
LEU A 220
VAL A 127
ALA A  10
VAL A 446
 None
 1.23A 2g72A-5u6sA:
undetectable		 2g72A-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 PHE A 196
LEU A 220
VAL A 127
ALA A  10
VAL A 446
 None
 1.23A 2g72B-5u6sA:
undetectable		 2g72B-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 5 GLN A  24
THR A  20
THR A 348
LEU A 331
 None
UDP  A 503 ( 4.3A)
None
None
 1.31A 2zj0A-5u6sA:
3.6		 2zj0A-5u6sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 5 GLN A  24
THR A  20
THR A 348
LEU A 331
 None
UDP  A 503 ( 4.3A)
None
None
 1.32A 3ce6A-5u6sA:
undetectable		 3ce6A-5u6sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 5 GLN A  24
THR A  20
THR A 348
LEU A 331
 None
UDP  A 503 ( 4.3A)
None
None
 1.34A 3ce6C-5u6sA:
undetectable		 3ce6C-5u6sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 11 GLY A  64
THR A  90
ASP A  74
ALA A  73
ASP A  66
 None
 1.14A 3id5B-5u6sA:
3.2		 3id5B-5u6sA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 11 GLY A  64
THR A  90
ASP A  74
ALA A  73
ASP A  66
 None
 1.14A 3id5F-5u6sA:
undetectable		 3id5F-5u6sA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ASN A 346
GLY A 344
GLN A 367
VAL A 138
THR A 225
 UDP  A 503 (-3.7A)
UDP  A 503 (-3.6A)
None
None
None
 1.40A 3mnoA-5u6sA:
undetectable		 3mnoA-5u6sA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ASN A 346
GLY A 344
GLN A 367
VAL A 138
THR A 225
 UDP  A 503 (-3.7A)
UDP  A 503 (-3.6A)
None
None
None
 1.38A 3mnpA-5u6sA:
undetectable		 3mnpA-5u6sA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 7 ILE A 156
VAL A 141
LEU A 144
SER A 145
 None
 0.57A 3r9vA-5u6sA:
undetectable
3r9vB-5u6sA:
undetectable		 3r9vA-5u6sA:
21.01
3r9vB-5u6sA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 PRO A 224
LEU A 231
LEU A 328
TYR A 241
TYR A 268
 None
None
None
UDP  A 503 (-4.3A)
None
 1.38A 4a79A-5u6sA:
undetectable		 4a79A-5u6sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 8 ASP A 238
ASP A 232
ASP A 440
ASP A 436
 None
 1.13A 4gkiE-5u6sA:
undetectable
4gkiG-5u6sA:
undetectable		 4gkiE-5u6sA:
22.05
4gkiG-5u6sA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 6 ASP A 440
GLY A 433
PRO A 224
THR A 225
 None
 1.10A 4l1aB-5u6sA:
undetectable		 4l1aB-5u6sA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 4 VAL A 384
THR A 386
GLU A 397
GLU A 387
 None
 1.32A 4l78A-5u6sA:
undetectable		 4l78A-5u6sA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 5 GLN A  24
THR A  20
LEU A 331
LEU A 328
 None
UDP  A 503 ( 4.3A)
None
None
 0.92A 4lvcB-5u6sA:
4.9		 4lvcB-5u6sA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ALA A  73
GLY A  69
PHE A  70
THR A  41
LEU A 114
 None
None
LB2  A 502 (-3.7A)
None
None
 0.98A 4n48B-5u6sA:
2.9		 4n48B-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ALA A  73
GLY A  69
PHE A  70
THR A  41
LEU A 114
 None
None
LB2  A 502 (-3.7A)
None
None
 1.01A 4n49A-5u6sA:
3.1		 4n49A-5u6sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 5 ILE A 105
CYH A 107
LEU A  34
HIS A   7
 None
 1.29A 5hrqC-5u6sA:
undetectable
5hrqD-5u6sA:
undetectable
5hrqL-5u6sA:
undetectable		 5hrqC-5u6sA:
4.11
5hrqD-5u6sA:
6.69
5hrqL-5u6sA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 ILE A 398
VAL A 269
PHE A 271
ILE A 392
ALA A 393
 None
 1.18A 5n0sB-5u6sA:
undetectable		 5n0sB-5u6sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 12 VAL A   8
LEU A  38
ALA A  10
PHE A  22
ARG A  28
 None
 1.30A 5nd4B-5u6sA:
4.8		 5nd4B-5u6sA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		7 / 7 THR A  15
HIS A  18
PHE A 113
GLN A 134
MET A 183
MET A 274
THR A 365
 7WV  A 504 (-3.7A)
7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
None
7WV  A 504 ( 3.5A)
7WV  A 504 (-3.2A)
 0.38A 5u6mA-5u6sA:
65.4		 5u6mA-5u6sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		7 / 7 THR A  15
HIS A  18
PHE A 113
GLN A 134
MET A 183
MET A 274
THR A 365
 7WV  A 504 (-3.7A)
7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
None
7WV  A 504 ( 3.5A)
7WV  A 504 (-3.2A)
 0.31A 5u6mB-5u6sA:
66.8		 5u6mB-5u6sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		7 / 8 HIS A  18
PHE A 113
GLN A 134
MET A 183
MET A 274
TRP A 364
THR A 365
 7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
None
7WV  A 504 ( 3.5A)
BGC  A 501 (-4.2A)
7WV  A 504 (-3.2A)
 0.31A 5u6nA-5u6sA:
66.1		 5u6nA-5u6sA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		5 / 6 HIS A  18
PHE A 113
GLN A 134
MET A 274
THR A 365
 7WV  A 504 (-4.6A)
7WV  A 504 (-4.8A)
7WV  A 504 (-3.0A)
7WV  A 504 ( 3.5A)
7WV  A 504 (-3.2A)
 0.25A 5u6nB-5u6sA:
67.7		 5u6nB-5u6sA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5u6s UDP-GLYCOSYLTRANSFER
ASE 74F2
(Arabidopsis
thaliana) 		4 / 5 THR A 106
ARG A   5
THR A 441
ASP A 436
 None
 1.34A 6ecxA-5u6sA:
2.2		 6ecxA-5u6sA:
21.59