SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		5 / 12 ASP A 126
THR A 253
GLY A 368
ALA A 129
ALA A 132
 None
HEM  A 501 (-4.5A)
None
None
None
 1.21A 1nw5A-5u6uA:
undetectable		 1nw5A-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		3 / 3 MET A 121
GLU A 369
ASN A 283
 None
 1.12A 3a27A-5u6uA:
undetectable		 3a27A-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		5 / 12 PHE A 298
GLY A  81
LEU A 323
ALA A 184
VAL A 181
 HEM  A 501 (-3.9A)
None
None
None
None
 1.03A 3av6A-5u6uA:
undetectable		 3av6A-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		3 / 3 ALA A 248
THR A 252
CYH A 358
 HEM  A 501 ( 3.3A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.48A 3e4eA-5u6uA:
28.6		 3e4eA-5u6uA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		3 / 3 ALA A 248
THR A 252
CYH A 358
 HEM  A 501 ( 3.3A)
HEM  A 501 (-3.6A)
HEM  A 501 (-2.3A)
 0.39A 3e4eB-5u6uA:
28.5		 3e4eB-5u6uA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 359
ILE A 124
MET A 121
VAL A 159
TYR A 155
 HEM  A 501 (-4.7A)
None
None
None
None
 1.41A 3sp6A-5u6uA:
undetectable		 3sp6A-5u6uA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		3 / 3 GLU A 287
ASP A 340
ASP A 337
 None
 0.76A 4gc9A-5u6uA:
undetectable		 4gc9A-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		3 / 4 SER A  95
GLY A 360
GLU A 367
 81M  A 502 (-2.5A)
HEM  A 501 (-3.6A)
None
 0.56A 4juoA-5u6uA:
undetectable
4juoC-5u6uA:
undetectable		 4juoA-5u6uA:
11.42
4juoC-5u6uA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		5 / 11 ILE A 145
ASP A 385
ALA A 147
LEU A 151
VAL A 261
 None
 1.31A 5hw4B-5u6uA:
undetectable		 5hw4B-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		5 / 12 GLN A  38
ASP A  33
ARG A 397
ARG A 290
ARG A 390
 None
 1.49A 5uacC-5u6uA:
undetectable		 5uacC-5u6uA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 5u6u CYTOCHROME P450
(Rhodopseudomonas
palustris) 		4 / 8 LEU A 375
VAL A 404
LEU A 406
ILE A 145
 None
 0.95A 6cb4A-5u6uA:
undetectable		 6cb4A-5u6uA:
undetectable