SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 LEU A 496
GLU A 489
LEU A 809
LEU A 787
GLY A 784
 None
 1.42A 1d4fD-5u70A:
2.1		 1d4fD-5u70A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_1
(DIHYDROFOLATE
REDUCTASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 4 GLU A 371
ASN A 611
ARG A 517
THR A 950
 None
 1.42A 1drfA-5u70A:
undetectable		 1drfA-5u70A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 7 THR A 965
LEU A 967
GLY A 970
LEU A 980
 None
 0.91A 1gtiE-5u70A:
undetectable		 1gtiE-5u70A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 VAL A 299
LEU A 278
SER A 306
VAL A 310
 None
 1.17A 1jtvA-5u70A:
7.2		 1jtvA-5u70A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 LEU A 260
ILE A 252
ALA A 317
PHE A 262
PHE A 291
 None
 1.10A 2ejtA-5u70A:
4.5		 2ejtA-5u70A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 6 HIS A 593
PHE A 559
ARG A 578
GLY A 576
 None
 1.34A 2i30A-5u70A:
2.7		 2i30A-5u70A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 7 GLY A 978
MET A 961
GLY A 576
PHE A 602
 None
 0.98A 3ko0M-5u70A:
undetectable
3ko0P-5u70A:
undetectable		 3ko0M-5u70A:
7.82
3ko0P-5u70A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 7 MET A 832
LEU A 811
ASP A 812
SER A 779
 None
 1.42A 3lslA-5u70A:
undetectable
3lslD-5u70A:
undetectable		 3lslA-5u70A:
13.21
3lslD-5u70A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 7 SER A 779
MET A 832
LEU A 811
ASP A 812
 None
 1.41A 3lslA-5u70A:
undetectable
3lslD-5u70A:
undetectable		 3lslA-5u70A:
13.21
3lslD-5u70A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 THR A 507
LEU A 511
LEU A 512
ILE A1148
 None
 0.92A 3nbqB-5u70A:
undetectable		 3nbqB-5u70A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 5 SER A 516
ARG A 923
ASP A 367
THR A 510
 None
 1.39A 3okxA-5u70A:
undetectable		 3okxA-5u70A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 5 SER A 516
ARG A 923
ASP A 367
THR A 510
 None
 1.41A 3okxB-5u70A:
undetectable		 3okxB-5u70A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 9 LEU A 951
VAL A 513
GLU A 488
LEU A 969
ILE A 509
 None
 1.19A 3tbgD-5u70A:
undetectable		 3tbgD-5u70A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 LEU A 360
VAL A 408
VAL A 398
LEU A 355
 None
 1.08A 3v81C-5u70A:
undetectable		 3v81C-5u70A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 SER A 779
ILE A 836
LEU A 888
ILE A 847
 None
 0.94A 4dtaB-5u70A:
undetectable		 4dtaB-5u70A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 11 ASP A 871
SER A 898
MET A 947
VAL A 942
THR A 874
 None
 1.45A 4eilA-5u70A:
undetectable		 4eilA-5u70A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 11 ASP A 871
SER A 898
MET A 947
VAL A 942
THR A 874
 None
 1.44A 4eilC-5u70A:
2.9		 4eilC-5u70A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		3 / 3 CYH A 106
ASN A 197
LYS A 102
 None
 1.31A 4k50A-5u70A:
undetectable		 4k50A-5u70A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 10 ASP A 871
SER A 898
MET A 947
VAL A 942
THR A 874
 None
 1.43A 4kyaC-5u70A:
undetectable		 4kyaC-5u70A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 11 ASP A 871
SER A 898
MET A 947
VAL A 942
THR A 874
 None
 1.42A 4kyaE-5u70A:
2.3		 4kyaE-5u70A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 LEU A 360
VAL A 408
VAL A 398
LEU A 355
 None
 1.12A 4pwdC-5u70A:
undetectable		 4pwdC-5u70A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 LEU A 360
VAL A 408
VAL A 398
LEU A 355
 None
 1.08A 4q0bA-5u70A:
undetectable		 4q0bA-5u70A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 5 TYR A 911
GLU A 526
LEU A1143
GLN A 529
 None
 1.27A 4qztB-5u70A:
undetectable		 4qztB-5u70A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 ILE A1148
LEU A 511
MET A 932
LEU A 929
 None
 0.99A 5u4sB-5u70A:
4.5		 5u4sB-5u70A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		5 / 12 ALA A 566
LEU A 574
ILE A 575
ILE A1009
PHE A 999
 None
 1.18A 5uanB-5u70A:
undetectable		 5uanB-5u70A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1
(Gallus
gallus) 		4 / 8 HIS A 352
PHE A 433
HIS A 375
PHE A 368
 None
 1.08A 5y2tB-5u70A:
undetectable		 5y2tB-5u70A:
undetectable