SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.44A 1oe1A-5u7nA:
5.7		 1oe1A-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 5 HIS A 114
CYH A 149
PRO A 151
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
None
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.72A 1oe2A-5u7nA:
8.1		 1oe2A-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.46A 1oe3A-5u7nA:
5.5		 1oe3A-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 9 GLY A 115
ILE A 107
ALA A  85
VAL A  83
PHE A 105
 None
 1.13A 2drdA-5u7nA:
undetectable		 2drdA-5u7nA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.55A 2fqdA-5u7nA:
3.1		 2fqdA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.52A 2fqeA-5u7nA:
3.7		 2fqeA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.51A 2fqfA-5u7nA:
4.1		 2fqfA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.49A 2fqgA-5u7nA:
3.1		 2fqgA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.46A 2xxgA-5u7nA:
8.2		 2xxgA-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 5 HIS A 114
CYH A 149
PRO A 151
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
None
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.77A 2xxgC-5u7nA:
8.1		 2xxgC-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 5 PRO A  94
ILE A  95
PRO A  92
TYR A  90
 None
 1.20A 3d9lA-5u7nA:
undetectable
3d9lY-5u7nA:
undetectable		 3d9lA-5u7nA:
undetectable
3d9lY-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 4 HIS A 114
CYH A 149
HIS A 152
MET A 155
 CU  A1000 (-3.3A)
CU  A1000 (-2.3A)
CU  A1000 (-3.1A)
CU  A1000 (-2.3A)
 0.46A 4ef3A-5u7nA:
3.9		 4ef3A-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 VAL A 104
THR A 134
ARG A 136
 None
 0.73A 5b2sB-5u7nA:
undetectable		 5b2sB-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		3 / 3 VAL A 104
THR A 134
ARG A 136
 None
 0.75A 5b2tB-5u7nA:
undetectable		 5b2tB-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		4 / 5 GLN A  91
VAL A  83
TRP A  64
THR A 134
 None
 1.42A 6cduI-5u7nA:
undetectable
6cduJ-5u7nA:
undetectable		 6cduI-5u7nA:
undetectable
6cduJ-5u7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5u7n CYTOCHROME C OXIDASE
SUBUNIT 2
(Thermus
thermophilus) 		5 / 12 ILE A 103
PHE A 116
VAL A 135
THR A 121
VAL A 118
 None
 1.16A 6djzA-5u7nA:
undetectable		 6djzA-5u7nA:
undetectable