SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u7q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  99
VAL A 106
ALA A 119
VAL A 153
LEU A 221
ASP A 232
PHE A 384
 None
 0.64A 1fmoE-5u7qA:
35.9		 1fmoE-5u7qA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
VAL A 153
ASN A 219
LEU A 221
ASP A 232
PHE A 384
 None
 0.67A 1fmoE-5u7qA:
35.9		 1fmoE-5u7qA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 GLY A  99
VAL A 106
ALA A 119
TYR A 171
LEU A 221
 None
 0.51A 1muoA-5u7qA:
10.0		 1muoA-5u7qA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
GLY A 175
ALA A 231
 None
 0.89A 1opjB-5u7qA:
18.6		 1opjB-5u7qA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
VAL A 153
GLY A 175
LEU A 221
ASP A 232
 None
 1.02A 1t46A-5u7qA:
19.3		 1t46A-5u7qA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 ILE A 364
LEU A 288
ILE A 329
PHE A 354
 None
 0.90A 1uwjA-5u7qA:
7.6		 1uwjA-5u7qA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 ARG A 213
ASP A 232
ASP A 176
 None
 0.83A 2ejtA-5u7qA:
undetectable		 2ejtA-5u7qA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
LYS A 121
VAL A 153
ASP A 176
ASN A 219
LEU A 221
ALA A 231
ASP A 232
 None
 0.73A 2eufB-5u7qA:
24.8		 2eufB-5u7qA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 GLY A  99
VAL A 106
ALA A 119
MET A 169
TYR A 171
LEU A 221
 None
 0.40A 2evaA-5u7qA:
21.1		 2evaA-5u7qA:
29.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
MET A 169
TYR A 171
LYS A 216
ASN A 219
ASP A 232
 None
 0.66A 2fumB-5u7qA:
23.5		 2fumB-5u7qA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
GLY A 175
LEU A 221
ALA A 231
 None
 0.65A 2gqgB-5u7qA:
13.7		 2gqgB-5u7qA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
ILE A 143
VAL A 153
GLY A 174
LEU A 221
ALA A 231
ASP A 232
 None
 1.20A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
ILE A 143
VAL A 153
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 1.09A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
GLY A 175
LEU A 221
ALA A 231
 None
 0.93A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
ILE A 143
VAL A 153
GLY A 175
LEU A 221
ALA A 231
 None
 1.00A 2hyyC-5u7qA:
18.6		 2hyyC-5u7qA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
 None
 0.73A 2itoA-5u7qA:
21.4		 2itoA-5u7qA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 GLY A  99
VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
ASP A 232
 None
 0.84A 2ityA-5u7qA:
21.1		 2ityA-5u7qA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
ASP A 232
 None
 0.79A 2itzA-5u7qA:
16.6		 2itzA-5u7qA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 1.05A 2oiqA-5u7qA:
19.6		 2oiqA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 11 LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
 None
 1.21A 2q6hA-5u7qA:
undetectable		 2q6hA-5u7qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 11 LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
 None
 1.15A 2qeiA-5u7qA:
undetectable		 2qeiA-5u7qA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 11 LEU A 284
LEU A 288
ILE A 329
PHE A 315
LEU A 313
 None
 1.19A 2qjuA-5u7qA:
undetectable		 2qjuA-5u7qA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 11 HIS A 212
MET A 237
CYH A 275
GLY A 272
VAL A 251
 None
 0.99A 2uxpB-5u7qA:
undetectable		 2uxpB-5u7qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 GLY A  99
VAL A 106
ALA A 119
TYR A 171
MET A 172
GLY A 175
ALA A 231
ASP A 232
 None
 0.77A 2wgjA-5u7qA:
20.2		 2wgjA-5u7qA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
ASP A 232
 None
 0.60A 2xp2A-5u7qA:
20.7		 2xp2A-5u7qA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ILE A  98
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
 None
 0.76A 2y6oA-5u7qA:
19.6		 2y6oA-5u7qA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LYS A  96
ILE A  98
ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
 None
 1.02A 2y6oA-5u7qA:
19.6		 2y6oA-5u7qA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  98
VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
 None
 0.45A 2y7jA-5u7qA:
28.6		 2y7jA-5u7qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ILE A  98
VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
 None
 0.57A 2y7jB-5u7qA:
29.0		 2y7jB-5u7qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ILE A  98
VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
 None
 0.56A 2y7jC-5u7qA:
28.6		 2y7jC-5u7qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ILE A  98
VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
 None
 0.63A 2y7jD-5u7qA:
28.4		 2y7jD-5u7qA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
LYS A 121
GLU A 140
VAL A 153
MET A 172
GLY A 175
LEU A 221
ALA A 231
 None
 0.69A 2zvaA-5u7qA:
22.2		 2zvaA-5u7qA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ALA A 119
LYS A 121
VAL A 153
MET A 172
GLY A 175
LEU A 221
 None
 0.61A 3aoxA-5u7qA:
19.8		 3aoxA-5u7qA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 GLY A  99
GLY A 101
VAL A 106
ALA A 119
VAL A 153
MET A 169
TYR A 171
LEU A 221
 None
 0.59A 3fupB-5u7qA:
22.4		 3fupB-5u7qA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 VAL A 106
ALA A 119
VAL A 153
TYR A 171
GLY A 175
LEU A 221
 None
 0.50A 3g0eA-5u7qA:
18.3		 3g0eA-5u7qA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 VAL A 106
ALA A 119
TYR A 171
GLY A 175
ASP A 176
LEU A 221
 None
 0.42A 3g0fA-5u7qA:
19.3		 3g0fA-5u7qA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
LEU A 221
ALA A 231
 None
 0.63A 3g5dA-5u7qA:
20.3		 3g5dA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.88A 3g5dB-5u7qA:
20.2		 3g5dB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.73A 3g5dB-5u7qA:
20.2		 3g5dB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 ARG A 131
GLU A 395
TYR A 164
 None
 0.75A 3k37B-5u7qA:
undetectable		 3k37B-5u7qA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
LYS A 121
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
 None
 0.67A 3k54A-5u7qA:
19.4		 3k54A-5u7qA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 GLY A  99
VAL A 106
ALA A 119
LYS A 121
VAL A 153
MET A 169
TYR A 171
ALA A 231
 None
 0.82A 3lxkA-5u7qA:
22.2		 3lxkA-5u7qA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 GLY A  99
VAL A 106
ALA A 119
VAL A 153
MET A 169
TYR A 171
LEU A 221
ALA A 231
 None
 0.86A 3lxkA-5u7qA:
22.2		 3lxkA-5u7qA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 ILE A  98
ALA A 119
LYS A 121
VAL A 153
MET A 172
LEU A 221
 None
 0.78A 3miyA-5u7qA:
19.6		 3miyA-5u7qA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
LYS A 121
VAL A 153
TYR A 171
GLY A 175
LEU A 221
 None
 0.63A 3octA-5u7qA:
3.2		 3octA-5u7qA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
TYR A 171
LEU A 221
ALA A 231
 None
 0.91A 3oezB-5u7qA:
19.6		 3oezB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.72A 3qlgA-5u7qA:
20.1		 3qlgA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
 None
 0.81A 3qlgA-5u7qA:
20.1		 3qlgA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
 None
 0.68A 3qlgA-5u7qA:
20.1		 3qlgA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.84A 3qlgB-5u7qA:
20.3		 3qlgB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.67A 3qlgB-5u7qA:
20.3		 3qlgB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 119
MET A 172
GLY A 175
ASP A 176
LEU A 221
ASP A 232
 None
 0.68A 3zbfA-5u7qA:
21.2		 3zbfA-5u7qA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 9 VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.66A 4anqA-5u7qA:
20.5		 4anqA-5u7qA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 9 VAL A 106
ALA A 119
MET A 169
MET A 172
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.69A 4ansA-5u7qA:
20.5		 4ansA-5u7qA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 106
ALA A 119
GLU A 140
ILE A 143
MET A 144
MET A 167
 None
 0.90A 4bkjB-5u7qA:
19.4		 4bkjB-5u7qA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
ASP A 176
ASP A 214
LYS A 216
ASN A 219
LEU A 221
ASP A 232
 None
 0.69A 4i41A-5u7qA:
25.4		 4i41A-5u7qA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 VAL A 106
ALA A 119
LYS A 121
ASP A 176
LEU A 221
ASP A 232
 None
 0.78A 4iaaA-5u7qA:
25.3		 4iaaA-5u7qA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 GLY A  99
VAL A 106
ALA A 119
LEU A 155
GLY A 175
LEU A 221
 None
 0.44A 4ifgA-5u7qA:
23.0		 4ifgA-5u7qA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 ILE A  98
ALA A 119
VAL A 153
MET A 169
GLY A 175
LEU A 221
 None
 0.52A 4ks8A-5u7qA:
22.8		 4ks8A-5u7qA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.84A 4mxoB-5u7qA:
21.2		 4mxoB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
VAL A 153
TYR A 171
MET A 172
GLY A 175
LEU A 221
 None
 0.85A 4mxxB-5u7qA:
19.6		 4mxxB-5u7qA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
GLU A 140
VAL A 153
MET A 169
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.74A 4mxyA-5u7qA:
21.4		 4mxyA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.75A 4mxyA-5u7qA:
21.4		 4mxyA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.89A 4mxyA-5u7qA:
21.4		 4mxyA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
VAL A 153
MET A 169
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.85A 4mxyB-5u7qA:
21.4		 4mxyB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.76A 4mxyB-5u7qA:
21.4		 4mxyB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
GLU A 140
VAL A 153
MET A 169
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.74A 4mxzA-5u7qA:
21.4		 4mxzA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.75A 4mxzA-5u7qA:
21.4		 4mxzA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
TYR A 171
GLY A 175
LEU A 221
ASP A 232
 None
 0.89A 4mxzA-5u7qA:
21.4		 4mxzA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
VAL A 153
MET A 169
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.85A 4mxzB-5u7qA:
21.4		 4mxzB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.76A 4mxzB-5u7qA:
21.4		 4mxzB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 VAL A 106
ALA A 119
ASP A 176
ASN A 219
LEU A 221
ASP A 232
 None
 0.85A 4ogrI-5u7qA:
25.8		 4ogrI-5u7qA:
26.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  99
GLY A 101
GLY A 104
VAL A 106
ALA A 119
LEU A 221
PHE A 384
 None
 0.42A 4otiA-5u7qA:
30.5		 4otiA-5u7qA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  99
GLY A 101
VAL A 106
ALA A 119
LEU A 221
ALA A 231
PHE A 384
 None
 0.57A 4otiA-5u7qA:
30.5		 4otiA-5u7qA:
33.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  99
VAL A 106
ALA A 119
VAL A 153
LEU A 221
ALA A 231
PHE A 384
 None
 0.53A 4otiA-5u7qA:
30.5		 4otiA-5u7qA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
LYS A 121
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
ASP A 232
 None
 0.93A 4otwA-5u7qA:
18.7		 4otwA-5u7qA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  98
ALA A 119
GLU A 140
TYR A 171
LEU A 221
ALA A 231
ASP A 232
 None
 0.73A 4qmnA-5u7qA:
27.9		 4qmnA-5u7qA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  98
ALA A 119
LYS A 121
GLU A 140
TYR A 171
LEU A 221
 None
 0.66A 4qmnA-5u7qA:
27.9		 4qmnA-5u7qA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 11 ILE A  98
ALA A 119
LYS A 121
GLU A 140
TYR A 171
LEU A 221
ASP A 232
 None
 0.88A 4qmsA-5u7qA:
27.6		 4qmsA-5u7qA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  98
GLY A  99
VAL A 106
ALA A 119
MET A 169
TYR A 171
LEU A 221
 None
 0.56A 4qmzA-5u7qA:
27.7		 4qmzA-5u7qA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 VAL A 106
ALA A 119
LYS A 121
MET A 172
GLY A 175
ASN A 219
LEU A 221
ALA A 231
ASP A 232
 None
 0.62A 4twpA-5u7qA:
21.3		 4twpA-5u7qA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		9 / 12 VAL A 106
ALA A 119
LYS A 121
MET A 172
GLY A 175
ASN A 219
LEU A 221
ALA A 231
ASP A 232
 None
 0.73A 4twpB-5u7qA:
21.4		 4twpB-5u7qA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 119
GLU A 140
MET A 144
HIS A 212
LEU A 221
ALA A 231
 None
 1.10A 4tyjA-5u7qA:
19.6		 4tyjA-5u7qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 119
MET A 144
ILE A 143
HIS A 212
LEU A 221
ALA A 231
 None
 1.47A 4tyjA-5u7qA:
19.6		 4tyjA-5u7qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 MET A 144
ILE A 143
CYH A 236
LEU A 221
ALA A 231
ASP A 232
 None
 1.41A 4tyjA-5u7qA:
19.6		 4tyjA-5u7qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		10 / 11 GLY A 101
VAL A 106
ALA A 119
TYR A 171
MET A 172
GLY A 175
ASN A 219
LEU A 221
ALA A 231
ASP A 232
 None
 0.52A 4u5jA-5u7qA:
22.0		 4u5jA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 9 VAL A 106
ALA A 119
TYR A 171
MET A 172
GLY A 175
LEU A 221
ASP A 232
 None
 0.78A 4u5jB-5u7qA:
21.5		 4u5jB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 ALA A 119
MET A 169
MET A 172
LEU A 221
 None
 0.24A 4wboC-5u7qA:
28.9		 4wboC-5u7qA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
GLU A 140
VAL A 153
TYR A 171
MET A 172
GLY A 175
LEU A 221
ALA A 231
 None
 0.66A 4xliA-5u7qA:
22.1		 4xliA-5u7qA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.72A 4xliB-5u7qA:
22.0		 4xliB-5u7qA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ALA A 119
LYS A 121
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.63A 4xliB-5u7qA:
22.0		 4xliB-5u7qA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 158
VAL A 168
GLN A  86
GLU A  90
TYR A 416
 None
 1.26A 4zj8A-5u7qA:
undetectable		 4zj8A-5u7qA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 VAL A 106
ALA A 119
MET A 172
GLY A 175
LEU A 221
ASP A 232
 None
 0.64A 5aaaA-5u7qA:
20.9		 5aaaA-5u7qA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 10 VAL A 106
ALA A 119
LYS A 121
MET A 172
GLY A 175
LEU A 221
ASP A 232
 None
 0.84A 5aabA-5u7qA:
20.5		 5aabA-5u7qA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 ASN A  42
SER A  45
ARG A 141
 None
 0.91A 5b2qA-5u7qA:
undetectable		 5b2qA-5u7qA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
GLY A 175
LEU A 221
ALA A 231
 None
 0.93A 5bvwA-5u7qA:
19.1		 5bvwA-5u7qA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 140
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.90A 5bvwA-5u7qA:
19.1		 5bvwA-5u7qA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 5 ALA A 191
TYR A 194
PRO A 217
GLY A 101
LEU A 221
 None
 1.48A 5eslA-5u7qA:
undetectable		 5eslA-5u7qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  98
ALA A 119
LYS A 121
GLU A 140
TYR A 171
GLY A 175
LEU A 221
 None
 0.83A 5i9xA-5u7qA:
15.4		 5i9xA-5u7qA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 ILE A  98
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
 None
 0.71A 5i9yA-5u7qA:
20.0		 5i9yA-5u7qA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 7 GLY A  99
GLY A 101
VAL A 106
LYS A 121
LEU A 123
 None
 0.41A 5izjA-5u7qA:
34.6		 5izjA-5u7qA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 7 GLY A  99
GLY A 101
VAL A 106
LYS A 121
ASP A 232
 None
 0.85A 5j5xA-5u7qA:
36.5		 5j5xA-5u7qA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY A  99
VAL A 106
ALA A 119
VAL A 153
ASP A 176
LEU A 221
ALA A 231
 None
 0.55A 5l2iA-5u7qA:
7.6		 5l2iA-5u7qA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  98
GLY A  99
ALA A 119
VAL A 153
ASP A 176
LEU A 221
ALA A 231
 None
 1.13A 5l2tA-5u7qA:
7.6		 5l2tA-5u7qA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  98
VAL A 106
ALA A 119
VAL A 153
ASP A 176
LEU A 221
ALA A 231
 None
 1.13A 5l2tA-5u7qA:
7.6		 5l2tA-5u7qA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 GLY A  99
VAL A 106
ALA A 119
VAL A 153
TYR A 171
LEU A 221
 None
 0.43A 5lvnA-5u7qA:
26.9		 5lvnA-5u7qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 9 ILE A  98
GLY A  99
VAL A 106
ALA A 119
MET A 169
MET A 172
 None
 0.59A 5lw1B-5u7qA:
23.3		 5lw1B-5u7qA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 GLY A  99
VAL A 106
ALA A 119
MET A 169
MET A 172
 None
 0.55A 5lw1E-5u7qA:
23.2		 5lw1E-5u7qA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 GLY A  99
VAL A 106
ALA A 119
MET A 169
MET A 172
 None
 0.42A 5lw1H-5u7qA:
23.5		 5lw1H-5u7qA:
10.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 10 VAL A 106
ALA A 119
VAL A 153
MET A 169
TYR A 171
LEU A 221
PHE A 384
 None
 0.56A 5n3hA-5u7qA:
36.6		 5n3hA-5u7qA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 108
ALA A 119
MET A 144
GLY A 175
ASN A 179
LEU A 221
 None
 1.06A 5te0A-5u7qA:
24.7		 5te0A-5u7qA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 108
ALA A 119
VAL A 153
GLY A 175
ASN A 179
LEU A 221
 None
 0.86A 5te0A-5u7qA:
24.7		 5te0A-5u7qA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  98
ALA A 119
GLU A 140
TYR A 171
GLY A 175
ASP A 232
 None
 0.82A 5vc3A-5u7qA:
23.4		 5vc3A-5u7qA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  98
GLY A  99
ALA A 119
TYR A 171
GLY A 175
ASP A 176
 None
 1.11A 5vc3A-5u7qA:
23.4		 5vc3A-5u7qA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 ILE A  98
GLY A  99
ALA A 119
TYR A 171
GLY A 175
ASP A 232
 None
 0.79A 5vc3A-5u7qA:
23.4		 5vc3A-5u7qA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 ARG A  83
PHE A 410
LEU A  55
 None
 0.94A 5x1bC-5u7qA:
1.9		 5x1bC-5u7qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		3 / 3 TYR A 171
LEU A 221
ASP A 232
 None
 0.67A 5zv2B-5u7qA:
18.9		 5zv2B-5u7qA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 ILE A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 172
LEU A 221
 None
 0.74A 6fnmA-5u7qA:
20.2		 6fnmA-5u7qA:
23.33