SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 11 GLY B 209
LEU B 211
GLY B 206
TYR B 370
PHE A 133
 None
 1.26A 1iolA-5u7zB:
undetectable		 1iolA-5u7zB:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 12 GLY A 103
LEU A 127
ILE A 131
ILE B 240
TRP B 239
 None
 1.22A 1kyvA-5u7zA:
undetectable
1kyvE-5u7zA:
undetectable		 1kyvA-5u7zA:
18.88
1kyvE-5u7zA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE B 240
TRP B 239
GLY A 103
LEU A 127
ILE A 131
 None
 1.22A 1kyvB-5u7zB:
undetectable
1kyvC-5u7zB:
undetectable		 1kyvB-5u7zB:
13.38
1kyvC-5u7zB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE B 240
TRP B 239
GLY A 103
LEU A 127
ILE A 131
 None
 1.22A 1kyvC-5u7zB:
undetectable
1kyvD-5u7zB:
undetectable		 1kyvC-5u7zB:
13.38
1kyvD-5u7zB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 12 ILE B 240
TRP B 239
GLY A 103
LEU A 127
ILE A 131
 None
 1.20A 1kyvD-5u7zB:
undetectable
1kyvE-5u7zB:
undetectable		 1kyvD-5u7zB:
13.38
1kyvE-5u7zB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 11 TYR B 233
ILE B 236
ALA B 277
ILE B 249
PHE A 136
 None
 1.21A 1uduA-5u7zB:
undetectable		 1uduA-5u7zB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 6 SER B 220
GLY B 213
THR B 212
ARG B 159
 None
 1.03A 2f7fA-5u7zB:
undetectable		 2f7fA-5u7zB:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 6 ARG B 333
THR B 319
THR B 295
ASP B 297
 SO4  B 406 (-3.7A)
SO4  B 406 (-3.0A)
None
SO4  B 407 (-2.5A)
 1.28A 2okcB-5u7zB:
undetectable		 2okcB-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5u7z ACID CERAMIDASE
ACID CERAMIDASE
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE B 275
PHE B 227
PHE A 140
TYR A 137
 None
 1.26A 3elzB-5u7zB:
2.8		 3elzB-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 7 VAL B 376
VAL B 147
ASN B 286
GLY B 285
 None
None
NAG  B 405 (-1.9A)
None
 1.01A 3kmoB-5u7zB:
undetectable		 3kmoB-5u7zB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 12 GLY B 291
GLY B 284
ILE B 349
MET B 354
VAL B 316
 None
 1.07A 3nk7A-5u7zB:
undetectable		 3nk7A-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 7 ILE A 135
LEU A 127
THR A 123
ARG A  61
 None
None
None
SO4  A 202 (-2.7A)
 1.09A 3nxuA-5u7zA:
undetectable		 3nxuA-5u7zA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 8 THR B 144
TYR B 370
ARG B 333
LEU B 364
 None
None
SO4  B 406 (-3.7A)
None
 1.11A 3wipG-5u7zB:
undetectable
3wipH-5u7zB:
undetectable		 3wipG-5u7zB:
undetectable
3wipH-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 8 ARG B 333
LEU B 364
THR B 144
TYR B 370
 SO4  B 406 (-3.7A)
None
None
None
 1.10A 3wipF-5u7zB:
undetectable
3wipJ-5u7zB:
undetectable		 3wipF-5u7zB:
undetectable
3wipJ-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 10 LEU B 358
ARG B 334
THR B 372
HIS B 157
VAL B 316
 None
 1.40A 4mk4A-5u7zB:
undetectable		 4mk4A-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 9 LEU B 307
GLY B 291
ILE B 349
MET B 354
VAL B 316
 None
 1.15A 4x3mA-5u7zB:
undetectable		 4x3mA-5u7zB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 9 LEU B 307
GLY B 291
ILE B 349
MET B 354
VAL B 316
 None
 1.13A 4x3mB-5u7zB:
undetectable		 4x3mB-5u7zB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		5 / 12 LEU B 221
PHE B 199
GLU B 258
VAL B 256
GLY B 206
 None
None
NAG  B 404 ( 2.7A)
None
None
 1.38A 4ydqA-5u7zB:
undetectable		 4ydqA-5u7zB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 6 LEU B 276
TRP B 248
PRO A 109
GLU A 115
 None
 1.10A 5b8iA-5u7zB:
undetectable		 5b8iA-5u7zB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5u7z ACID CERAMIDASE
ACID CERAMIDASE
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A 106
GLY A 103
LEU A 101
LEU B 237
GLU B 238
 None
 1.01A 5c0oH-5u7zA:
undetectable		 5c0oH-5u7zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 5 ARG B 254
PHE B 204
LEU B 211
LEU A  65
 NAG  B 404 ( 4.8A)
None
None
None
 1.16A 5veuH-5u7zB:
undetectable		 5veuH-5u7zB:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5u7z ACID CERAMIDASE
ACID CERAMIDASE
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLU A 115
GLY A 118
VAL B 187
LEU B 185
ASN A 134
 None
 1.18A 5vopB-5u7zA:
undetectable		 5vopB-5u7zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 7 VAL B 147
LEU B 189
PHE B 219
LEU B 257
 None
 0.93A 6aycA-5u7zB:
undetectable		 6aycA-5u7zB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5u7z ACID CERAMIDASE
(Homo
sapiens) 		4 / 6 ILE B 249
LEU B 252
TYR B 207
THR B 212
 None
 1.03A 6nmfN-5u7zB:
undetectable
6nmfW-5u7zB:
undetectable		 6nmfN-5u7zB:
undetectable
6nmfW-5u7zB:
undetectable