SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 ILE A 282
ILE A 147
ALA A 337
LEU A 354
ILE A 357
 None
 1.03A 1bsxA-5u81A:
undetectable		 1bsxA-5u81A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 ILE A 282
ILE A 147
ALA A 337
LEU A 354
ILE A 357
 None
 1.03A 1bsxB-5u81A:
undetectable		 1bsxB-5u81A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 9 LEU A 236
ILE A 240
PHE A 108
GLY A 106
LEU A 101
 None
 1.10A 1e7aB-5u81A:
undetectable		 1e7aB-5u81A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 TYR A 137
ALA A 201
GLY A 213
LEU A 257
ARG A 159
 None
 1.15A 1vpoH-5u81A:
undetectable
1vpoL-5u81A:
undetectable		 1vpoH-5u81A:
15.38
1vpoL-5u81A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 LEU A 236
ILE A 240
PHE A 108
GLY A 106
LEU A 101
 None
 1.20A 2bxeB-5u81A:
undetectable		 2bxeB-5u81A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 6 SER A 220
GLY A 213
THR A 212
ARG A 159
 None
 0.97A 2f7fA-5u81A:
undetectable		 2f7fA-5u81A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 ILE A 282
ILE A 147
ALA A 337
LEU A 354
ILE A 357
 None
 1.09A 2h79A-5u81A:
undetectable		 2h79A-5u81A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 7 ILE A 294
SER A 301
ARG A 298
ILE A 249
 None
 1.16A 2q6hA-5u81A:
undetectable		 2q6hA-5u81A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 ILE A 146
THR A 371
THR A 144
VAL A 317
ILE A 357
 None
 1.30A 2yzqA-5u81A:
undetectable		 2yzqA-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 5 VAL A 363
LEU A 358
ILE A 357
VAL A 317
 None
 0.99A 4a9kB-5u81A:
undetectable		 4a9kB-5u81A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 5 ILE A 119
ALA A 205
HIS A  63
MET A  66
 None
 1.29A 4ac9B-5u81A:
undetectable
4ac9C-5u81A:
undetectable		 4ac9B-5u81A:
undetectable
4ac9C-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 5 ILE A 119
ALA A 205
HIS A  63
MET A  66
 None
 1.27A 4acaB-5u81A:
undetectable
4acaC-5u81A:
undetectable		 4acaB-5u81A:
undetectable
4acaC-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 11 ILE A  52
LEU A 189
THR A 202
VAL A 187
TYR A 207
 None
 1.11A 4g1bB-5u81A:
undetectable		 4g1bB-5u81A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 ILE A  52
LEU A 189
THR A 202
VAL A 187
TYR A 207
 None
 1.11A 4g1bD-5u81A:
undetectable		 4g1bD-5u81A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 6 ILE A 269
ILE A 294
SER A 301
LEU A 275
 PG4  A 418 ( 3.8A)
None
None
None
 0.99A 4m51A-5u81A:
undetectable		 4m51A-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 LEU A 275
ILE A 249
GLY A 250
VAL A 256
LEU A 221
 None
None
None
PG4  A 418 ( 3.9A)
None
 1.05A 4y8wA-5u81A:
undetectable		 4y8wA-5u81A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 LEU A 275
ILE A 249
GLY A 250
VAL A 256
LEU A 221
 None
None
None
PG4  A 418 ( 3.9A)
None
 1.11A 4y8wB-5u81A:
undetectable		 4y8wB-5u81A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 GLU A 264
LEU A 270
LYS A 267
GLY A 284
LEU A 257
 None
 1.34A 5kbwA-5u81A:
undetectable		 5kbwA-5u81A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 6 ARG A 298
ALA A 279
PRO A 278
GLU A 138
 None
 1.38A 5odqA-5u81A:
undetectable		 5odqA-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 5 ARG A 254
PHE A 204
LEU A 211
LEU A  65
 NAG  A 408 ( 4.1A)
None
None
None
 1.31A 5veuH-5u81A:
undetectable		 5veuH-5u81A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 6 THR A 144
PRO A 336
GLN A 338
ILE A 146
 None
 1.26A 6ef6A-5u81A:
undetectable		 6ef6A-5u81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		5 / 12 VAL A 177
ILE A 178
MET A  94
VAL A  77
ILE A  76
 CL  A 417 (-4.4A)
CL  A 417 (-3.9A)
None
None
None
 1.34A 6gsdA-5u81A:
undetectable		 6gsdA-5u81A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5u81 ACID CERAMIDASE
ISOFORM B
(Heterocephalus
glaber) 		4 / 5 GLY A 213
THR A 212
HIS A 157
SER A 145
 None
 1.15A 6jmjA-5u81A:
undetectable		 6jmjA-5u81A:
undetectable