SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 7 TRP A  62
LEU A 211
GLY A 209
LEU A 189
 None
 1.07A 1gtiD-5u84A:
undetectable		 1gtiD-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		5 / 12 THR A 141
GLU A 138
ARG A 159
ILE A 282
PHE A 281
 None
I3C  A 412 (-2.7A)
None
None
None
 1.39A 1oltA-5u84A:
undetectable		 1oltA-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 4 GLY A 285
SER A 220
ILE A 147
HIS A 157
 None
 1.30A 1yajJ-5u84A:
undetectable		 1yajJ-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 7 PHE A 108
LEU A 105
ASN A 134
ILE A 135
 None
None
None
I3C  A 412 (-4.3A)
 0.90A 1yc2E-5u84A:
undetectable		 1yc2E-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		5 / 12 ILE A 125
LEU A  80
ILE A  76
PHE A 204
ILE A 130
 None
 0.98A 2cd2A-5u84A:
undetectable		 2cd2A-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		5 / 10 TYR A 370
GLY A 209
THR A 212
ALA A 202
ALA A 201
 None
 1.05A 2ej3B-5u84A:
undetectable		 2ej3B-5u84A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 8 TYR A 280
TYR A 137
LEU A 276
THR A 175
 None
None
I3C  A 412 (-4.7A)
None
 1.11A 2v0zO-5u84A:
undetectable		 2v0zO-5u84A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 4 GLY A 379
ASP A 375
GLY A 284
THR A 212
 None
I3C  A 407 (-3.3A)
None
None
 1.03A 3k4vC-5u84A:
undetectable		 3k4vC-5u84A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 5 ASN A 224
ASP A 162
GLU A 180
SER A 145
 None
 1.44A 3p2kC-5u84A:
undetectable		 3p2kC-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		5 / 11 PHE A 136
ILE A 237
GLY A 235
LEU A 167
PHE A  87
 None
 1.13A 3t3rA-5u84A:
undetectable		 3t3rA-5u84A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 6 ILE A  76
ILE A  52
TRP A  62
MET A  66
 None
 1.46A 3welA-5u84A:
undetectable		 3welA-5u84A:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 5 PHE A 381
GLY A 203
THR A 186
VAL A  47
 None
 1.03A 3wrkD-5u84A:
undetectable		 3wrkD-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		4 / 6 PHE A 191
MET A 210
ILE A  52
ARG A  61
 None
None
None
IOD  A 430 ( 4.3A)
 1.42A 4mk4B-5u84A:
undetectable		 4mk4B-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5u84 ACID CERAMIDASE
(Balaenoptera
acutorostrata) 		5 / 9 LEU A 307
GLY A 291
ILE A 349
MET A 354
VAL A 316
 None
None
None
None
IOD  A 417 ( 4.2A)
 1.17A 4x3mB-5u84A:
undetectable		 4x3mB-5u84A:
11.72