SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 5u8q FV 24-60 HEAVY CHAIN
INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens;
Mus
musculus) 		4 / 7 TYR H  54
GLU A  53
PHE A 241
ARG A 245
 None
None
None
MLT  A1003 ( 4.8A)
 1.47A 1b2iA-5u8qH:
undetectable		 1b2iA-5u8qH:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 11 ALA A 801
GLY A 800
GLU A 799
ASN A 883
ASN A 829
 None
None
None
NAG  A1013 (-1.8A)
None
 1.06A 1n6cA-5u8qA:
undetectable		 1n6cA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 10 ASP A 624
TYR A 632
LEU A 833
ARG A 641
TYR A 628
 None
 1.44A 1rmtA-5u8qA:
undetectable		 1rmtA-5u8qA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 8 PRO A 639
LEU A 880
GLY A 830
LEU A 627
 None
 0.95A 1ya4A-5u8qA:
undetectable		 1ya4A-5u8qA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 358
ILE A 332
LEU A 330
GLU A 304
ILE A 311
 None
 1.17A 2gj5A-5u8qA:
undetectable		 2gj5A-5u8qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 331
LEU A 320
ALA A 317
LEU A 372
LEU A 366
 None
 1.37A 2oaxE-5u8qA:
undetectable		 2oaxE-5u8qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 475
ILE A 574
ILE A 477
VAL A 522
VAL A 524
 None
 1.06A 2ygoA-5u8qA:
undetectable		 2ygoA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 11 LEU A  32
ILE A   9
ARG A  18
VAL A  88
LEU A  87
 None
 1.38A 3a9eB-5u8qA:
undetectable		 3a9eB-5u8qA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 4 PRO A 236
THR A 238
GLY A 228
THR A 216
 None
 1.14A 3ib1A-5u8qA:
undetectable		 3ib1A-5u8qA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A  73
GLY A  67
PHE A  45
LEU A  48
PRO A  46
 None
 1.27A 3mecA-5u8qA:
undetectable		 3mecA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 101
GLY A  99
ASP A  97
 None
 0.68A 3ou6C-5u8qA:
undetectable		 3ou6C-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 5 ILE A 476
THR A 469
THR A 468
SER A 467
 None
 1.19A 3snfA-5u8qA:
undetectable		 3snfA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 745
TYR A 628
GLN A 623
 None
 1.06A 5jsdA-5u8qA:
3.4
5jsdB-5u8qA:
0.7		 5jsdA-5u8qA:
9.15
5jsdB-5u8qA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 745
TYR A 628
GLN A 623
 None
 1.06A 5jsdB-5u8qA:
0.7
5jsdC-5u8qA:
1.8		 5jsdB-5u8qA:
9.15
5jsdC-5u8qA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A  76
GLY A  78
LEU A  48
LEU A  19
LEU A  29
 None
 1.17A 5nfjC-5u8qA:
undetectable		 5nfjC-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
FV 24-60 HEAVY CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 TRP A 244
GLY A  27
ILE A  25
TYR H  54
LEU A  19
 None
 1.36A 5nz0A-5u8qA:
undetectable		 5nz0A-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TYR A 839
ASP A 845
GLN A 846
 None
 0.73A 6g1pA-5u8qA:
undetectable		 6g1pA-5u8qA:
undetectable