SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 10 VAL 4 628
VAL 4 708
VAL 4 536
ILE 4 562
LEU 4 672
 None
 1.27A 1fe2A-5u8s4:
undetectable		 1fe2A-5u8s4:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 152
VAL E 148
GLU E 239
LEU E 237
LEU E 131
 None
 1.35A 1mrqA-5u8sE:
undetectable		 1mrqA-5u8sE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 5 GLU E 433
LEU E 546
LEU E 543
LEU E 545
 None
 0.79A 1np1A-5u8sE:
undetectable		 1np1A-5u8sE:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 5 GLU E 433
LEU E 546
LEU E 543
LEU E 548
 None
 1.07A 1np1A-5u8sE:
undetectable		 1np1A-5u8sE:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 PRO E 566
THR E 245
HIS E 126
LEU E 569
VAL E 568
 None
 1.20A 1r30B-5u8sE:
undetectable		 1r30B-5u8sE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 12 GLU 4 799
MET 4 801
ASP 4 821
ALA 4 825
ILE 4 829
 None
 1.40A 1s14B-5u8s4:
undetectable		 1s14B-5u8s4:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		4 / 5 ILE 4 415
SER 4 335
ARG 4 334
LEU 4 417
 None
 1.09A 1y0xX-5u8s4:
undetectable		 1y0xX-5u8s4:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 11 ILE E 629
PHE E 625
ASP E 124
HIS E 126
GLY E  85
 None
 0.93A 1zz1A-5u8sE:
undetectable		 1zz1A-5u8sE:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 ILE E 629
PHE E 625
ASP E 124
HIS E 126
GLY E  85
 None
 1.08A 1zz1B-5u8sE:
undetectable
1zz1C-5u8sE:
undetectable		 1zz1B-5u8sE:
19.72
1zz1C-5u8sE:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 6 LEU E 258
LEU E 259
LEU E  45
LEU E 123
 None
 0.82A 2ab2A-5u8sE:
undetectable		 2ab2A-5u8sE:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		3 / 3 LYS 4 302
ASP 4 462
CYH 4 418
 None
 1.43A 2br4F-5u8s4:
undetectable		 2br4F-5u8s4:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 12 GLN 4 876
LEU 4 919
VAL 4 872
LEU 4 873
SER 4 926
 None
 1.19A 2c12C-5u8s4:
undetectable		 2c12C-5u8s4:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 11 GLN 4 876
LEU 4 919
VAL 4 872
LEU 4 873
SER 4 926
 None
 1.20A 2c12F-5u8s4:
undetectable		 2c12F-5u8s4:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 GLY E  85
GLY E  87
ASP E 124
ALA E 125
ALA E  38
 None
 0.96A 2gluA-5u8sE:
undetectable		 2gluA-5u8sE:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 7 GLY E 153
THR E 151
GLN E 155
PHE E 135
 None
 1.16A 2qx4A-5u8sE:
4.4
2qx4B-5u8sE:
4.5		 2qx4A-5u8sE:
17.21
2qx4B-5u8sE:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		3 / 3 GLU 4 799
GLN 4 652
ARG 4 557
 None
 0.99A 2w3bB-5u8s4:
undetectable		 2w3bB-5u8s4:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		3 / 3 SER 4 908
ARG 4 924
GLN 4 904
 None
 0.91A 2xnrA-5u8s4:
undetectable		 2xnrA-5u8s4:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 TYR E  64
LEU E  83
VAL E  84
SER E  32
LEU E 258
 None
 1.00A 2zlcA-5u8sE:
undetectable		 2zlcA-5u8sE:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 MET E 362
MET E 366
PHE E 392
PHE E 363
LEU E 328
 None
 1.43A 3aocC-5u8sE:
undetectable		 3aocC-5u8sE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 8 PHE E 625
ASP E 124
HIS E 126
GLY E  85
 None
 0.71A 3c0zB-5u8sE:
undetectable		 3c0zB-5u8sE:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		4 / 8 ILE 4 751
HIS 4 582
VAL 4 628
GLY 4 627
 None
 0.81A 3em0B-5u8s4:
undetectable		 3em0B-5u8s4:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 GLN E 141
SER E  32
LEU E  45
TYR E 121
LEU E 123
 None
 1.37A 3fsuA-5u8sE:
undetectable		 3fsuA-5u8sE:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 11 GLN E 141
SER E  32
LEU E  45
TYR E 121
LEU E 123
 None
 1.36A 3fsuE-5u8sE:
undetectable		 3fsuE-5u8sE:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		3 / 3 THR E 278
GLU E 426
HIS E 331
 None
 0.71A 3g1uB-5u8sE:
undetectable		 3g1uB-5u8sE:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		3 / 3 ASP E 124
PHE E  86
SER E 627
 None
 1.00A 3i5uB-5u8sE:
3.2		 3i5uB-5u8sE:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		3 / 3 ARG E 634
ASP E 636
ASP E 577
 None
 0.88A 3jb3A-5u8sE:
undetectable		 3jb3A-5u8sE:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 7 TYR E 335
HIS E 360
PHE E 507
VAL E 511
 None
 1.09A 3jwqC-5u8sE:
undetectable		 3jwqC-5u8sE:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 11 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.18A 3m8pA-5u8sE:
2.7
3m8pB-5u8sE:
undetectable		 3m8pA-5u8sE:
20.91
3m8pB-5u8sE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.15A 3mecA-5u8sE:
2.7		 3mecA-5u8sE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.13A 3medA-5u8sE:
undetectable
3medB-5u8sE:
undetectable		 3medA-5u8sE:
20.94
3medB-5u8sE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 LEU E  45
VAL E  84
TYR E 121
PHE E   8
LEU E 258
 None
 1.01A 3meeA-5u8sE:
2.3		 3meeA-5u8sE:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 GLU E  97
ILE E  98
PHE E 116
ALA E  94
ILE E 139
 None
 1.28A 3ndiA-5u8sE:
3.2		 3ndiA-5u8sE:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 6 ALA E 427
ILE E 496
VAL E 489
ASN E 493
 None
 0.94A 3nneG-5u8sE:
undetectable		 3nneG-5u8sE:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 12 LEU 4 623
GLU 4 647
GLY 4 619
SER 4 618
LEU 4 601
 None
 1.41A 3ou6D-5u8s4:
undetectable		 3ou6D-5u8s4:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 7 VAL E 148
LEU E 152
TYR E 240
LEU E 602
 None
 0.85A 3qeoB-5u8sE:
undetectable		 3qeoB-5u8sE:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 348
ILE E 404
PHE E 363
MET E 362
HIS E 360
 None
 1.34A 3qt0A-5u8sE:
undetectable		 3qt0A-5u8sE:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 8 PHE E  95
ILE E 139
TYR E  71
LEU E  67
 None
 1.01A 3rqwI-5u8sE:
undetectable
3rqwJ-5u8sE:
undetectable		 3rqwI-5u8sE:
18.35
3rqwJ-5u8sE:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 9 ILE 4 829
LEU 4 704
ILE 4 564
MET 4 649
ILE 4 562
 None
 1.15A 3zosA-5u8s4:
2.1		 3zosA-5u8s4:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 9 ILE 4 829
LEU 4 704
ILE 4 564
MET 4 649
ILE 4 562
 None
 1.15A 3zosB-5u8s4:
2.3		 3zosB-5u8s4:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		6 / 10 LEU E  45
LEU E  16
ILE E  15
TYR E 121
LEU E  82
PHE E  49
 None
 1.16A 4odoA-5u8sE:
undetectable		 4odoA-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 10 LEU E  45
LEU E  16
ILE E  15
TYR E 121
PHE E  49
 None
 0.93A 4odoB-5u8sE:
undetectable		 4odoB-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		6 / 10 LEU E  45
LEU E  16
ILE E  15
TYR E 121
LEU E  82
PHE E  49
 None
 1.15A 4odoC-5u8sE:
undetectable		 4odoC-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		6 / 10 LEU E 359
LEU E 401
ILE E 404
LEU E 396
LEU E 329
PHE E 392
 None
 1.41A 4odoC-5u8sE:
undetectable		 4odoC-5u8sE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 LEU E  45
LEU E  16
ILE E  15
TYR E 121
PHE E  49
 None
 0.96A 4odrA-5u8sE:
undetectable
4odrB-5u8sE:
undetectable		 4odrA-5u8sE:
11.22
4odrB-5u8sE:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 11 LEU E  45
LEU E  16
ILE E  15
TYR E 121
PHE E  49
 None
 0.96A 4odrA-5u8sE:
undetectable
4odrB-5u8sE:
undetectable		 4odrA-5u8sE:
11.22
4odrB-5u8sE:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 8 LEU E  45
VAL E  84
TYR E 121
LEU E 258
 None
 0.87A 4q0bA-5u8sE:
2.4		 4q0bA-5u8sE:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		3 / 3 LYS 4 874
ARG 4 925
VAL 4 927
 None
 1.00A 4x3uA-5u8s4:
undetectable
4x3uB-5u8s4:
undetectable		 4x3uA-5u8s4:
4.82
4x3uB-5u8s4:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 12 THR E 509
ALA E 512
GLU E 515
LEU E 514
LEU E 530
 None
 1.31A 4xi3A-5u8sE:
undetectable		 4xi3A-5u8sE:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 7 ASN E 342
TYR E 339
TYR E 335
LEU E 334
 None
 1.23A 4yv5A-5u8sE:
undetectable		 4yv5A-5u8sE:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		3 / 3 VAL E 410
THR E 412
ARG E 330
 None
 0.76A 5b2sB-5u8sE:
undetectable		 5b2sB-5u8sE:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		3 / 3 VAL E 410
THR E 412
ARG E 330
 None
 0.76A 5b2tB-5u8sE:
0.0		 5b2tB-5u8sE:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		5 / 10 ILE E 368
LEU E 334
VAL E 344
LEU E 348
LEU E 370
 None
 1.13A 5ienB-5u8sE:
undetectable		 5ienB-5u8sE:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 5 HIS E 331
ILE E 496
SER E 420
ALA E 427
 None
 1.20A 5msdA-5u8sE:
undetectable		 5msdA-5u8sE:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		5 / 12 LEU 4 544
ILE 4 671
ILE 4 577
VAL 4 581
LEU 4 578
 None
 0.96A 5mugA-5u8s4:
undetectable		 5mugA-5u8s4:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		4 / 8 ALA 4 793
ILE 4 829
ALA 4 832
ILE 4 833
 None
 0.70A 5mvmA-5u8s4:
undetectable
5mvmB-5u8s4:
undetectable		 5mvmA-5u8s4:
7.09
5mvmB-5u8s4:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 8 ASN E 342
ARG E 547
THR E 429
ILE E 282
 None
 0.92A 5nzxA-5u8sE:
2.3		 5nzxA-5u8sE:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5u8s DNA REPLICATION
LICENSING FACTOR
MCM4
(Saccharomyces
cerevisiae) 		4 / 6 LEU 4 544
TYR 4 706
ASP 4 703
GLN 4 797
 None
 1.18A 6djzC-5u8s4:
undetectable		 6djzC-5u8s4:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 8 ILE E 255
GLN E 254
THR E 147
VAL E 148
 None
 1.12A 6fbvC-5u8sE:
undetectable		 6fbvC-5u8sE:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5u8s CELL DIVISION
CONTROL PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 5 ASN E  35
GLY E 244
HIS E 126
ASP E 124
 None
 1.04A 6gh9A-5u8sE:
undetectable		 6gh9A-5u8sE:
9.03