SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 5 GLU A 122
ARG A 136
ASP A 217
THR A 193
 None
 1.44A 1k4tA-5u8zA:
undetectable		 1k4tA-5u8zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 TRP A 278
GLU A 165
TYR A 212
 None
83D  A 602 (-3.7A)
None
 1.26A 2a3aA-5u8zA:
undetectable		 2a3aA-5u8zA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 SER A 167
ASP A 217
CYH A 266
 None
 1.16A 2br4E-5u8zA:
undetectable		 2br4E-5u8zA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 5 LEU A 239
GLY A 289
ILE A 247
ILE A 222
 None
 0.84A 2q9rA-5u8zA:
undetectable		 2q9rA-5u8zA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 6 TRP A 513
GLY A  99
GLY A 511
PHE A 102
 None
 1.01A 2qx6A-5u8zA:
undetectable
2qx6B-5u8zA:
undetectable		 2qx6A-5u8zA:
20.25
2qx6B-5u8zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 PRO A 174
GLY A 158
TYR A 155
 None
 0.75A 2vouA-5u8zA:
undetectable		 2vouA-5u8zA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 PRO A 174
GLY A 158
TYR A 155
 None
 0.70A 2vouB-5u8zA:
undetectable		 2vouB-5u8zA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 4 HIS A 313
HIS A 197
HIS A 248
HIS A 510
 FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
 1.11A 2wkoA-5u8zA:
undetectable		 2wkoA-5u8zA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 6 MET A 207
ARG A 157
PRO A 229
GLY A 231
 None
 1.45A 2y7pA-5u8zA:
undetectable		 2y7pA-5u8zA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		5 / 12 PHE A 102
LEU A 177
PHE A  72
LEU A 484
LEU A  58
 None
 1.47A 3adsA-5u8zA:
undetectable		 3adsA-5u8zA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 6 ASN A 152
ALA A 196
HIS A 248
ASP A 249
 None
None
FE2  A 601 ( 3.4A)
None
 1.18A 3aruA-5u8zA:
undetectable		 3aruA-5u8zA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		5 / 10 HIS A 248
HIS A 197
HIS A 313
THR A 151
PRO A  77
 FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
83D  A 602 (-3.5A)
None
 1.31A 3cajA-5u8zA:
undetectable		 3cajA-5u8zA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 HIS A 510
HIS A 197
HIS A 313
 FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 0.56A 3qpkA-5u8zA:
undetectable		 3qpkA-5u8zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 HIS A 510
HIS A 197
HIS A 313
 FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 0.54A 3qpkB-5u8zA:
undetectable		 3qpkB-5u8zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		5 / 12 GLN A 188
GLY A 228
GLY A 231
ASP A 230
ALA A 234
 None
 1.14A 3t7sA-5u8zA:
undetectable		 3t7sA-5u8zA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 7 HIS A 248
TYR A 133
TRP A  90
TRP A 340
 FE2  A 601 ( 3.4A)
83D  A 602 (-4.4A)
None
None
 1.27A 3uzzA-5u8zA:
undetectable		 3uzzA-5u8zA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 8 HIS A 313
PHE A 337
PRO A  77
TRP A  90
 FE2  A 601 ( 3.4A)
83D  A 602 (-4.6A)
None
None
 1.39A 3v35A-5u8zA:
undetectable		 3v35A-5u8zA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 8 ASP A 388
ASP A 518
ASP A 520
ASN A 460
 None
 1.11A 4feuD-5u8zA:
undetectable		 4feuD-5u8zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 5 THR A 148
GLY A  95
VAL A  75
PRO A  77
 None
 0.99A 4grkA-5u8zA:
undetectable		 4grkA-5u8zA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 GLU A 213
ARG A 134
HIS A 277
 None
 0.79A 4kf9A-5u8zA:
undetectable		 4kf9A-5u8zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 4 THR A 204
ARG A 394
GLU A 254
VAL A 203
 None
 1.20A 4odoC-5u8zA:
undetectable		 4odoC-5u8zA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 7 PHE A 185
ASP A 186
GLN A 188
PRO A 190
 None
 0.78A 4pcuA-5u8zA:
undetectable		 4pcuA-5u8zA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 HIS A 510
HIS A 197
HIS A 313
 FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 0.54A 5migA-5u8zA:
undetectable		 5migA-5u8zA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 6 HIS A 197
HIS A 248
LEU A 163
THR A 151
 FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
None
83D  A 602 (-3.5A)
 1.15A 5ogjA-5u8zA:
undetectable		 5ogjA-5u8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 6 HIS A 197
HIS A 248
LEU A 163
THR A 151
 FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
None
83D  A 602 (-3.5A)
 1.17A 5ogjB-5u8zA:
undetectable		 5ogjB-5u8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 5 HIS A 197
HIS A 248
LEU A 163
THR A 151
 FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
None
83D  A 602 (-3.5A)
 1.17A 5ohhA-5u8zA:
undetectable		 5ohhA-5u8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 6 HIS A 197
HIS A 248
LEU A 163
THR A 151
 FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
None
83D  A 602 (-3.5A)
 1.16A 5ohhB-5u8zA:
undetectable		 5ohhB-5u8zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 GLY A 521
THR A 179
PRO A 174
 None
CL  A 603 (-4.7A)
None
 0.62A 5v5zA-5u8zA:
undetectable		 5v5zA-5u8zA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 5 PRO A 458
GLY A 466
VAL A 391
ARG A 390
 None
 1.13A 5x80C-5u8zA:
undetectable
5x80D-5u8zA:
undetectable		 5x80C-5u8zA:
16.54
5x80D-5u8zA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 5 HIS A 313
HIS A 510
HIS A 197
HIS A 248
 FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 1.07A 5zrdB-5u8zA:
undetectable		 5zrdB-5u8zA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 4 HIS A 313
HIS A 510
HIS A 197
HIS A 248
 FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 1.05A 5zrdC-5u8zA:
undetectable		 5zrdC-5u8zA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		4 / 4 HIS A 313
HIS A 510
HIS A 197
HIS A 248
 FE2  A 601 ( 3.4A)
FE2  A 601 (-3.3A)
FE2  A 601 (-3.3A)
FE2  A 601 ( 3.4A)
 1.04A 5zrdD-5u8zA:
undetectable		 5zrdD-5u8zA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		3 / 3 ARG A 157
PHE A 227
GLY A 231
 None
 0.69A 6fgdA-5u8zA:
undetectable		 6fgdA-5u8zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5u8z CAROTENOID OXYGENASE
1
(Neurospora
crassa) 		5 / 11 ILE A 440
LEU A 433
THR A 489
LEU A 430
PHE A 400
 None
 1.44A 6hupA-5u8zA:
undetectable
6hupB-5u8zA:
undetectable		 6hupA-5u8zA:
10.36
6hupB-5u8zA:
10.08