SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 8 LEU A  13
ALA A  28
VAL A  37
VAL A  91
None
0.84A 1epbB-5u94A:
undetectable
1epbB-5u94A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  72
VAL A  95
ASN A 143
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
G93  A 301 (-4.1A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
0.54A 1fmoE-5u94A:
27.6
1fmoE-5u94A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 7 LYS A  40
VAL A  72
ILE A  90
ARG A 137
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
1.01A 1iepB-5u94A:
18.9
1iepB-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LEU A  17
LYS A  40
ILE A  90
ARG A 137
G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
0.94A 1opjB-5u94A:
18.7
1opjB-5u94A:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
12 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  95
ASP A 138
LYS A 140
ALA A 142
ASN A 143
MET A 145
MET A 155
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.1A)
None
G93  A 301 ( 4.3A)
G93  A 301 ( 3.1A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.2A)
0.57A 2fumA-5u94A:
40.4
2fumA-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
12 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
TYR A  94
VAL A  95
LYS A 140
ASN A 143
MET A 145
MET A 155
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
G93  A 301 ( 4.3A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.2A)
0.57A 2fumB-5u94A:
40.7
2fumB-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
11 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
TYR A  94
VAL A  95
THR A  99
ASN A 143
MET A 145
MET A 155
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
0.54A 2fumC-5u94A:
38.0
2fumC-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
9 / 12 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
MET A  92
THR A  99
ASN A 143
MET A 145
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
0.73A 2fumD-5u94A:
37.9
2fumD-5u94A:
84.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
10 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
MET A  92
THR A  99
LYS A 140
ASN A 143
MET A 145
MET A 155
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 4.3A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.4A)
0.64A 2fumD-5u94A:
37.9
2fumD-5u94A:
84.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LEU A  17
LYS A  40
VAL A  72
ILE A  90
G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.72A 2hyyB-5u94A:
24.1
2hyyB-5u94A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 12 LEU A  17
GLY A  18
VAL A  25
LYS A  40
GLU A  59
TYR A  94
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
None
0.53A 2ivuA-5u94A:
19.2
2ivuA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 MET A 155
ARG A 101
GLY A  20
MET A  22
G93  A 301 (-3.4A)
None
None
None
1.49A 3aqiB-5u94A:
undetectable
3aqiB-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 10 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.66A 3cs9A-5u94A:
15.0
3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 10 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.73A 3cs9A-5u94A:
15.0
3cs9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 9 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.60A 3cs9B-5u94A:
19.5
3cs9B-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 9 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.65A 3cs9B-5u94A:
19.5
3cs9B-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 9 LEU A  17
VAL A  25
LYS A  40
VAL A  72
ILE A  90
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.66A 3cs9C-5u94A:
19.5
3cs9C-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 9 LEU A  17
VAL A  25
VAL A  72
ILE A  90
VAL A 154
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.71A 3cs9C-5u94A:
19.5
3cs9C-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
MET A  92
ASN A 143
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-2.7A)
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
0.68A 3eygA-5u94A:
26.8
3eygA-5u94A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
MET A  92
TYR A  94
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 3.2A)
0.68A 3fupA-5u94A:
26.8
3fupA-5u94A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
9 / 12 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
LYS A  40
VAL A  72
MET A  92
TYR A  94
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
0.58A 3fupB-5u94A:
26.8
3fupB-5u94A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 11 LEU A  17
VAL A  25
ALA A  38
VAL A  72
TYR A  94
GLY A  97
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
None
GOL  A 305 ( 4.3A)
0.58A 3g0eA-5u94A:
16.3
3g0eA-5u94A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
7 / 12 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.54A 3g5dA-5u94A:
26.8
3g5dA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 7 LEU A  17
LYS A  40
ILE A  90
ARG A 137
G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
0.98A 3ik3A-5u94A:
5.3
3ik3A-5u94A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 7 LEU A  17
LYS A  40
ILE A  90
ARG A 137
G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
0.92A 3ik3B-5u94A:
18.0
3ik3B-5u94A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 12 GLU A 208
PRO A 214
VAL A 152
ILE A 144
ASN A 143
None
None
None
None
MG  A 310 (-3.2A)
1.47A 3jb2A-5u94A:
undetectable
3jb2A-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LEU A  17
LYS A  40
VAL A  72
ILE A  90
G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.69A 3k5vA-5u94A:
18.5
3k5vA-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LEU A  17
LYS A  40
VAL A  72
ILE A  90
G93  A 301 ( 3.8A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.72A 3k5vB-5u94A:
23.4
3k5vB-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
9 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
VAL A  72
MET A  92
TYR A  94
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
G93  A 301 ( 3.2A)
0.76A 3lxkA-5u94A:
26.4
3lxkA-5u94A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
7 / 12 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
TYR A  94
VAL A  95
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
G93  A 301 (-4.1A)
0.44A 3lxnA-5u94A:
27.0
3lxnA-5u94A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LYS A  40
VAL A  72
ILE A  90
ARG A 137
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.93A 3ms9A-5u94A:
2.7
3ms9A-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LYS A  40
VAL A  72
ILE A  90
ARG A 137
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.94A 3mssA-5u94A:
19.0
3mssA-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 LYS A  40
VAL A  72
ILE A  90
ARG A 137
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
0.96A 3mssC-5u94A:
18.9
3mssC-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 VAL A  25
LYS A  40
VAL A  72
ILE A  90
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
0.69A 3mssD-5u94A:
23.5
3mssD-5u94A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 10 VAL A 152
VAL A 209
MET A 110
ILE A 119
ILE A 146
None
None
GOL  A 306 (-3.9A)
None
GOL  A 306 ( 3.5A)
1.16A 3retA-5u94A:
2.0
3retB-5u94A:
undetectable
3retA-5u94A:
22.11
3retB-5u94A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 12 LEU A 202
THR A 179
ILE A 119
ALA A 115
LEU A 100
None
GOL  A 304 (-3.6A)
None
None
None
1.33A 3vw1B-5u94A:
undetectable
3vw1B-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 8 VAL A  25
LYS A  40
MET A 145
ASP A 156
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
0.60A 3warA-5u94A:
25.5
3warA-5u94A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 5 LYS A  40
LEU A  66
TYR A  94
ARG A 137
G93  A 301 (-3.0A)
None
None
None
1.38A 4bkjB-5u94A:
24.5
4bkjB-5u94A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 10 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
TYR A  94
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
None
0.21A 4ckjA-5u94A:
22.1
4ckjA-5u94A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 12 VAL A 251
LEU A 273
LEU A 247
LEU A 210
THR A 211
None
0.88A 4k13A-5u94A:
undetectable
4k13A-5u94A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 6 VAL A 152
VAL A 118
ILE A 119
LEU A 126
None
0.99A 4l1wB-5u94A:
undetectable
4l1wB-5u94A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 12 LEU A  17
VAL A  25
ALA A  38
LYS A  40
GLU A  59
ILE A  90
TYR A  94
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
0.83A 4mxoA-5u94A:
26.9
4mxoA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 12 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
0.95A 4mxyA-5u94A:
20.3
4mxyA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 12 LEU A  17
VAL A  25
ALA A  38
GLU A  59
VAL A  72
ILE A  90
TYR A  94
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
0.95A 4mxzA-5u94A:
20.3
4mxzA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 11 LEU A  17
GLY A  18
VAL A  25
ALA A  38
LYS A  40
THR A  99
ASN A 143
ASP A 156
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
MG  A 310 (-3.2A)
G93  A 301 ( 3.2A)
0.95A 4o0sA-5u94A:
30.1
4o0sA-5u94A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 11 ALA A  38
LYS A  40
GLU A  59
ILE A  90
TYR A  94
ASP A 156
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
G93  A 301 ( 3.2A)
0.78A 4qmsA-5u94A:
29.8
4qmsA-5u94A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 5 LEU A  17
VAL A  72
TYR A  94
ARG A 137
G93  A 301 ( 3.8A)
G93  A 301 (-4.0A)
None
None
0.39A 4r7iA-5u94A:
24.5
4r7iA-5u94A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
8 / 10 LEU A  17
VAL A  25
GLU A  59
LEU A  66
ILE A  71
VAL A  72
TYR A  94
ARG A 137
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.2A)
None
None
G93  A 301 (-4.0A)
None
None
0.95A 4u0iA-5u94A:
24.8
4u0iA-5u94A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 12 VAL A  25
ALA A  38
LYS A  40
ASP A 156
PHE A 157
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.2A)
G93  A 301 (-4.8A)
0.74A 4xv2A-5u94A:
21.6
4xv2A-5u94A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 12 VAL A  25
ALA A  38
LYS A  40
ILE A  90
TYR A  94
ASP A 102
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.8A)
None
None
0.79A 5hesB-5u94A:
23.6
5hesB-5u94A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 12 VAL A  25
ALA A  38
LYS A  40
TYR A  94
ASP A 102
GLY A 158
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
None
None
G93  A 301 ( 4.9A)
1.35A 5hesB-5u94A:
23.6
5hesB-5u94A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 7 GLY A  18
GLY A  20
VAL A  25
LYS A  40
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
0.22A 5izjA-5u94A:
27.5
5izjA-5u94A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 7 GLY A  18
GLY A  20
VAL A  25
LYS A  40
ASP A 156
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.2A)
0.61A 5j5xA-5u94A:
27.6
5j5xA-5u94A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 11 LEU A  17
GLY A  18
VAL A  25
ALA A  38
VAL A  72
TYR A  94
G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
None
0.36A 5lvnA-5u94A:
21.4
5lvnA-5u94A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 10 LEU A  17
VAL A  25
LYS A  40
GLU A  59
ILE A  90
GLY A  97
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
GOL  A 305 ( 4.3A)
0.72A 5mo4A-5u94A:
18.3
5mo4A-5u94A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
7 / 10 LEU A  17
VAL A  25
ALA A  38
VAL A  72
MET A  92
TYR A  94
VAL A  95
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
G93  A 301 (-4.1A)
0.73A 5n3hA-5u94A:
27.9
5n3hA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 12 GLU A  15
LEU A  27
ALA A  38
GLU A  59
VAL A  72
GLY A  97
None
GOL  A 307 ( 3.8A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.2A)
G93  A 301 (-4.0A)
GOL  A 305 ( 4.3A)
0.63A 5te0A-5u94A:
27.7
5te0A-5u94A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 12 ARG A  55
GLY A 158
GLU A  59
ILE A  90
LEU A  87
None
G93  A 301 ( 4.9A)
G93  A 301 (-3.2A)
G93  A 301 ( 3.8A)
None
1.21A 5ul4A-5u94A:
2.2
5ul4A-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
6 / 12 LEU A  17
VAL A  25
ALA A  38
LYS A  40
GLU A  59
GLY A  97
G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-3.2A)
GOL  A 305 ( 4.3A)
0.89A 5vcyA-5u94A:
27.0
5vcyA-5u94A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 9 LEU A  17
ALA A  38
VAL A  72
GLY A  97
MET A 145
G93  A 301 ( 3.8A)
G93  A 301 ( 3.7A)
G93  A 301 (-4.0A)
GOL  A 305 ( 4.3A)
G93  A 301 ( 3.7A)
0.99A 5w5vA-5u94A:
5.4
5w5vA-5u94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 8 VAL A  25
LYS A  40
MET A 145
ASP A 156
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
0.54A 5y9mX-5u94A:
25.0
5y9mX-5u94A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
4 / 7 VAL A  25
LYS A  40
MET A 145
ASP A 156
G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
0.77A 5yf9B-5u94A:
25.2
5yf9B-5u94A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis)
5 / 10 GLY A 203
LEU A 202
VAL A 209
ALA A 115
LEU A 273
None
1.14A 6czmA-5u94A:
undetectable
6czmC-5u94A:
undetectable
6czmA-5u94A:
undetectable
6czmC-5u94A:
undetectable