SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 147
PRO A  97
ALA A  96
ILE A 152
 None
 0.90A 2aofA-5u99A:
undetectable		 2aofA-5u99A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 4 ASP A  70
ASP A 154
ASP A 176
GLY A 157
 ATP  A 306 (-2.8A)
SO4  A 303 (-3.1A)
None
SO4  A 301 (-3.6A)
 1.50A 2igtC-5u99A:
undetectable		 2igtC-5u99A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 269
VAL A 254
ILE A 274
LEU A 215
PRO A 255
 None
 1.19A 5ienB-5u99A:
undetectable		 5ienB-5u99A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 154
ILE A 112
LEU A 174
LEU A 119
VAL A 120
 SO4  A 303 (-3.1A)
None
None
None
None
 1.05A 5twjC-5u99A:
undetectable		 5twjC-5u99A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  48
THR A  67
VAL A  57
ALA A  54
LEU A  62
 None
 0.97A 6czmA-5u99A:
23.3
6czmC-5u99A:
22.8		 6czmA-5u99A:
28.94
6czmC-5u99A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  87
VAL A   6
LEU A 181
LEU A  85
 None
 1.02A 6e43A-5u99A:
undetectable		 6e43A-5u99A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5u99 ATP
PHOSPHORIBOSYLTRANSF
ERASE
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  87
VAL A   6
LEU A 181
LEU A  85
 None
 1.01A 6e43B-5u99A:
undetectable		 6e43B-5u99A:
22.30