SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.17A 1utzA-5u9eA:
undetectable		 1utzA-5u9eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.18A 1utzB-5u9eA:
undetectable		 1utzB-5u9eA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.19A 2hu6A-5u9eA:
undetectable		 2hu6A-5u9eA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.14A 2ow9B-5u9eA:
undetectable		 2ow9B-5u9eA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.16A 2ozrC-5u9eA:
undetectable		 2ozrC-5u9eA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.14A 2ozrD-5u9eA:
undetectable		 2ozrD-5u9eA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.25A 2ozrE-5u9eA:
undetectable		 2ozrE-5u9eA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		5 / 12 ILE A  68
GLY A 106
PHE A 107
PRO A  91
LEU A  65
 None
 1.13A 3em0B-5u9eA:
undetectable		 3em0B-5u9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.20A 3lilA-5u9eA:
undetectable		 3lilA-5u9eA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		5 / 12 HIS A  34
HIS A  36
HIS A  74
HIS A  51
ILE A  88
 NI  A 202 ( 3.4A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.3A)
None
RM4  A 201 (-4.2A)
 1.25A 3njzA-5u9eA:
4.7		 3njzA-5u9eA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 ASN A  86
LEU A 155
PHE A  66
TYR A  67
 RM4  A 201 (-2.4A)
None
None
None
 1.39A 4u14A-5u9eA:
undetectable		 4u14A-5u9eA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 HIS A  74
GLU A  40
HIS A  36
HIS A  34
 NI  A 202 ( 3.3A)
NI  A 202 ( 2.6A)
NI  A 202 ( 3.3A)
NI  A 202 ( 3.4A)
 1.18A 5n5jA-5u9eA:
undetectable		 5n5jA-5u9eA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		5 / 12 TYR A  67
PHE A 152
ILE A  87
LEU A 155
GLY A 106
 None
 1.16A 5zwrA-5u9eA:
undetectable		 5zwrA-5u9eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 7 ASP A  37
ALA A  70
LYS A   6
LEU A   7
 None
None
None
RM4  A 201 (-4.5A)
 1.04A 6ci6A-5u9eA:
undetectable		 6ci6A-5u9eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR
(Bacteria
Latreille
et
al.
1825) 		4 / 4 MET A 123
GLY A 122
HIS A 162
GLY A 119
 None
 1.31A 6fgdA-5u9eA:
undetectable		 6fgdA-5u9eA:
undetectable