SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_A_08JA1_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 8	VAL A 332 LEU A 338 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.77A	3u5kA-5u9nA: 14.3	3u5kA-5u9nA: 23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_B_08JB2_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 7	VAL A 332 LEU A 338 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.78A	3u5kB-5u9nA: 14.2	3u5kB-5u9nA: 23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U5K_C_08JC3_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 8	VAL A 332 LEU A 338 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.80A	3u5kC-5u9nA: 14.3	3u5kC-5u9nA: 23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_A_TYLA1188_1 (BROMODOMAIN CONTAINING 2)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 5	VAL A 332 LEU A 338 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.84A	4a9jA-5u9nA: 15.4	4a9jA-5u9nA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_B_TYLB1187_1 (BROMODOMAIN CONTAINING 2)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 5	VAL A 332 LEU A 338 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.81A	4a9jB-5u9nA: 15.7	4a9jB-5u9nA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_C_TYLC1184_1 (BROMODOMAIN CONTAINING 2)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 5	VAL A 332 LEU A 338 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.77A	4a9jC-5u9nA: 15.2	4a9jC-5u9nA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NR3_A_95EA401_0 (DNA (CYTOSINE-5)-METHYLT RANSFERASE 3B)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 7	ILE A 392 PHE A 398 TRP A 308 SER A 440	None None SO4 A 502 (-4.4A) None	1.49A	5nr3A-5u9nA: undetectable	5nr3A-5u9nA: 21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5PBE_A_TYLA2001_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	4 / 6	VAL A 332 TYR A 346 ASN A 413 ILE A 422	BMF A 501 (-4.2A) None BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.65A	5pbeA-5u9nA: 15.3	5pbeA-5u9nA: 22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y1Y_A_HNQA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5u9n	BROMO DOMAIN CONTAINING PROTEIN (Cryptosporidium parvum)	5 / 8	VAL A 332 LEU A 338 CYH A 409 ASN A 413 ILE A 422	BMF A 501 (-4.2A) BMF A 501 ( 4.9A) BMF A 501 ( 3.8A) BMF A 501 (-2.8A) BMF A 501 ( 4.4A)	0.77A	5y1yA-5u9nA: 14.2	5y1yA-5u9nA: 24.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3U5K_A_08JA1_1","BROMODOMAIN-CONTAINING PROTEIN 4","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;LEU A 338;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.77A","3u5kA-5u9nA:14.3","3u5kA-5u9nA:23.87"],["3U5K_B_08JB2_1","BROMODOMAIN-CONTAINING PROTEIN 4","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;LEU A 338;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.78A","3u5kB-5u9nA:14.2","3u5kB-5u9nA:23.87"],["3U5K_C_08JC3_1","BROMODOMAIN-CONTAINING PROTEIN 4","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;LEU A 338;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.80A","3u5kC-5u9nA:14.3","3u5kC-5u9nA:23.87"],["4A9J_A_TYLA1188_1","BROMODOMAIN CONTAINING 2","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;LEU A 338;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.84A","4a9jA-5u9nA:15.4","4a9jA-5u9nA:20.88"],["4A9J_B_TYLB1187_1","BROMODOMAIN CONTAINING 2","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;LEU A 338;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.81A","4a9jB-5u9nA:15.7","4a9jB-5u9nA:20.88"],["4A9J_C_TYLC1184_1","BROMODOMAIN CONTAINING 2","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;LEU A 338;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.77A","4a9jC-5u9nA:15.2","4a9jC-5u9nA:20.88"],["5NR3_A_95EA401_0","DNA (CYTOSINE-5)-METHYLTRANSFERASE 3B","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"ILE A 392;PHE A 398;TRP A 308;SER A 440","None;None;SO4 A 502 (-4.4A);None","1.49A","5nr3A-5u9nA:undetectable","5nr3A-5u9nA:21.23"],["5PBE_A_TYLA2001_1","BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",4,"VAL A 332;TYR A 346;ASN A 413;ILE A 422","BMF A 501 (-4.2A);None;BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.65A","5pbeA-5u9nA:15.3","5pbeA-5u9nA:22.02"],["5Y1Y_A_HNQA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","5u9n","BROMO DOMAIN CONTAINING PROTEIN","Cryptosporidium parvum",5,"VAL A 332;LEU A 338;CYH A 409;ASN A 413;ILE A 422","BMF A 501 (-4.2A);BMF A 501 ( 4.9A);BMF A 501 ( 3.8A);BMF A 501 (-2.8A);BMF A 501 ( 4.4A)","0.77A","5y1yA-5u9nA:14.2","5y1yA-5u9nA:24.18"]]