SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5u9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		4 / 8 SER A 607
ALA A 578
PHE A 601
ILE A 577
 None
 1.17A 1gm7A-5u9zA:
undetectable
1gm7B-5u9zA:
undetectable		 1gm7A-5u9zA:
undetectable
1gm7B-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		4 / 7 PHE A 558
GLU A 534
TYR A 554
THR A 539
 None
 1.23A 1rmtB-5u9zA:
undetectable		 1rmtB-5u9zA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		4 / 8 PHE A 708
ASP A 623
LEU A 683
LEU A 506
 None
 0.98A 2bfpA-5u9zA:
undetectable		 2bfpA-5u9zA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 MET A 561
PHE A 535
ASN A 595
ILE A 645
LEU A 596
 None
 1.16A 2bjfA-5u9zA:
undetectable		 2bjfA-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 11 LEU A 683
ASN A 649
TYR A 627
VAL A 617
GLY A 618
 None
 1.27A 2bxgA-5u9zA:
undetectable		 2bxgA-5u9zA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 10 ILE A 795
ALA A 794
ILE A 802
GLU A 776
TYR A 462
 None
 1.25A 2dm6A-5u9zA:
undetectable
2dm6B-5u9zA:
undetectable		 2dm6A-5u9zA:
12.91
2dm6B-5u9zA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 HIS A 762
SER A 738
ASN A 742
VAL A 706
ILE A 512
 None
 1.40A 2o7oA-5u9zA:
undetectable		 2o7oA-5u9zA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 HIS A 762
SER A 738
ASN A 742
VAL A 706
ILE A 512
 None
 1.38A 2xpwA-5u9zA:
undetectable		 2xpwA-5u9zA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		4 / 5 ALA A 603
MET A 647
THR A 621
PHE A 611
 None
 1.22A 3vasB-5u9zA:
undetectable		 3vasB-5u9zA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		4 / 5 ASN A 779
SER A 782
LEU A 799
ASN A 545
 None
 1.04A 4n09C-5u9zA:
2.0		 4n09C-5u9zA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		4 / 8 ALA A 758
GLY A 519
VAL A 783
SER A 782
 None
 0.62A 4r20A-5u9zA:
undetectable		 4r20A-5u9zA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 11 SER A 491
ASP A 733
THR A 732
TYR A 679
LEU A 676
 None
 1.30A 5jh7B-5u9zA:
2.0		 5jh7B-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 11 SER A 491
ASP A 733
THR A 732
TYR A 679
LEU A 676
 None
 1.26A 5jh7D-5u9zA:
undetectable		 5jh7D-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 683
GLY A 710
PRO A 714
ASP A 711
GLU A 534
 None
None
None
MN  A 901 (-2.6A)
None
 1.34A 5x6yC-5u9zA:
undetectable		 5x6yC-5u9zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5u9z PHOSPHOGLYCEROL
TRANSFERASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 676
VAL A 501
PRO A 493
THR A 690
SER A 487
 None
 1.39A 5xiqB-5u9zA:
2.0		 5xiqB-5u9zA:
undetectable