SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		4 / 6 LEU A  85
LEU A  88
LEU A 100
LEU A 102
 None
 0.97A 2ab2A-5uagA:
undetectable		 2ab2A-5uagA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		4 / 5 LEU A  85
LEU A  88
LEU A 100
LEU A 102
 None
 0.98A 2ab2B-5uagA:
undetectable		 2ab2B-5uagA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		4 / 8 LYS A 200
GLU A 188
THR A  27
VAL A  14
 None
 0.73A 4ik6B-5uagA:
undetectable		 4ik6B-5uagA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		4 / 5 ARG A  91
GLN A  93
ILE A 211
ASP A 212
 None
 1.50A 4z4hA-5uagA:
undetectable		 4z4hA-5uagA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		5 / 9 ASP A 197
ALA A 189
VAL A 187
LYS A 200
GLU A  29
 None
 1.30A 4zbrA-5uagA:
undetectable		 4zbrA-5uagA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		3 / 3 VAL A  92
GLN A 147
CYH A  54
 None
 0.70A 5icxA-5uagA:
3.5
5icxE-5uagA:
undetectable		 5icxA-5uagA:
20.51
5icxE-5uagA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		3 / 3 VAL A  92
GLN A 147
CYH A  54
 None
 0.88A 5icxC-5uagA:
3.5
5icxF-5uagA:
undetectable		 5icxC-5uagA:
20.51
5icxF-5uagA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		5 / 11 ILE A  81
VAL A  64
SER A  69
MET A 142
LEU A 102
 None
 1.33A 5tiyA-5uagA:
undetectable		 5tiyA-5uagA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		5 / 9 ALA A 112
VAL A  90
ALA A  89
VAL A 146
GLY A  87
 None
 1.25A 6bklA-5uagA:
undetectable
6bklB-5uagA:
undetectable
6bklC-5uagA:
undetectable
6bklD-5uagA:
undetectable		 6bklA-5uagA:
6.27
6bklB-5uagA:
6.27
6bklC-5uagA:
6.27
6bklD-5uagA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA
(Escherichia
coli) 		4 / 7 ASP A 197
ALA A 189
LYS A 200
GLU A  29
 None
 1.06A 6ci6A-5uagA:
undetectable		 6ci6A-5uagA:
15.77