SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		4 / 7 PHE F 419
PHE F 427
ALA F 120
ILE F 123
 None
 0.93A 1fxhA-5uahF:
undetectable
1fxhB-5uahF:
2.3		 1fxhA-5uahF:
17.39
1fxhB-5uahF:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		4 / 8 GLU F 139
GLN F 346
SER F 272
TYR F 268
 None
 1.34A 1nx9A-5uahF:
undetectable		 1nx9A-5uahF:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		3 / 3 LYS F 299
LYS F 289
VAL F 292
 None
 0.75A 3brfA-5uahF:
undetectable		 3brfA-5uahF:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		5 / 11 ALA F 431
ILE F 435
GLY F 411
SER F 428
LEU F 386
 None
 1.13A 3kw2A-5uahF:
undetectable		 3kw2A-5uahF:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		5 / 11 ALA F 431
ILE F 435
GLY F 411
SER F 428
LEU F 386
 None
 1.15A 3kw2B-5uahF:
undetectable		 3kw2B-5uahF:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		4 / 7 ILE F 235
LEU F 353
THR F 142
THR F 311
 None
 1.15A 3nxuA-5uahF:
undetectable		 3nxuA-5uahF:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5uah RNA POLYMERASE SIGMA
FACTOR RPOD
(Escherichia
coli) 		4 / 8 MET F 322
ALA F 321
PHE F 316
PHE F 306
 None
 0.96A 4ltwA-5uahF:
undetectable		 4ltwA-5uahF:
16.64