SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 PHE A 305
ALA A 309
GLY A 241
LEU A 230
LEU A 233
 None
 1.34A 1jipA-5uakA:
0.0		 1jipA-5uakA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 11 LEU A1414
VAL A1240
ILE A1398
LEU A1227
LEU A1253
 None
 1.34A 1mrqA-5uakA:
undetectable		 1mrqA-5uakA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ALA A 274
VAL A 272
TRP A 277
 None
 0.95A 1nrmA-5uakA:
undetectable		 1nrmA-5uakA:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ALA A 274
VAL A 272
TRP A 277
 None
 0.95A 1nrmB-5uakA:
undetectable		 1nrmB-5uakA:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 ALA A1319
ALA A1357
LEU A1369
GLY A1323
LEU A1388
 None
 1.14A 1qabF-5uakA:
undetectable		 1qabF-5uakA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 LEU A1388
THR A1387
ILE A1289
GLY A1349
LEU A1353
 None
 1.01A 1qknA-5uakA:
2.2		 1qknA-5uakA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 ILE A1404
LEU A1414
LEU A1430
ILE A1398
SER A1373
 None
 1.02A 1zq9A-5uakA:
undetectable		 1zq9A-5uakA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 ILE A1103
ASP A1152
LEU A1034
ARG A1097
 None
 1.47A 2a7qA-5uakA:
undetectable		 2a7qA-5uakA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 9 LEU A1093
HIS A 199
ALA A 196
LEU A 197
GLU A  92
 None
 1.41A 2azqA-5uakA:
undetectable		 2azqA-5uakA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A 459
GLY A 458
GLY A 461
GLY A 463
 None
 0.79A 3bogB-5uakA:
undetectable
3bogD-5uakA:
undetectable		 3bogB-5uakA:
undetectable
3bogD-5uakA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 LYS A 532
SER A 549
GLN A 552
 None
 0.58A 3si7A-5uakA:
25.1		 3si7A-5uakA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 ILE A 991
ILE A 995
VAL A 862
GLY A 934
 None
 0.69A 4acaC-5uakA:
undetectable		 4acaC-5uakA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 ILE A 991
ILE A 995
VAL A 862
GLY A 934
 None
 0.77A 4acbC-5uakA:
undetectable		 4acbC-5uakA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ARG A1048
THR A1086
TRP A1089
 None
 1.10A 4d7hA-5uakA:
undetectable		 4d7hA-5uakA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 11 LEU A 453
SER A 624
LEU A 571
LEU A 568
ILE A 448
 None
 1.19A 4dm8A-5uakA:
1.4		 4dm8A-5uakA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 LEU A 227
LEU A 230
LEU A 233
ALA A 234
GLN A 237
 None
 0.82A 4fn9A-5uakA:
undetectable		 4fn9A-5uakA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.42A 4jksA-5uakA:
undetectable		 4jksA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.46A 4jksA-5uakA:
undetectable		 4jksA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.43A 4jksB-5uakA:
undetectable		 4jksB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.43A 4jkuA-5uakA:
undetectable		 4jkuA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.45A 4jkuA-5uakA:
undetectable		 4jkuA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_2
(SUGAR KINASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.42A 4k8cB-5uakA:
undetectable		 4k8cB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_2
(SUGAR KINASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.46A 4k8cB-5uakA:
undetectable		 4k8cB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_2
(SUGAR KINASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.43A 4k8kA-5uakA:
undetectable		 4k8kA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_2
(SUGAR KINASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.44A 4k8kA-5uakA:
undetectable		 4k8kA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_2
(SUGAR KINASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.45A 4k8kB-5uakA:
undetectable		 4k8kB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.43A 4kalA-5uakA:
undetectable		 4kalA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.45A 4kalA-5uakA:
undetectable		 4kalA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.43A 4kalB-5uakA:
undetectable		 4kalB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.46A 4kalB-5uakA:
undetectable		 4kalB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.44A 4lcaA-5uakA:
1.3		 4lcaA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.46A 4lcaA-5uakA:
1.3		 4lcaA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A 184
TYR A 161
PRO A 499
 None
 1.43A 4lcaB-5uakA:
undetectable		 4lcaB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 SER A1058
LEU A1082
TYR A 161
PRO A 499
 None
 1.45A 4lcaB-5uakA:
undetectable		 4lcaB-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 5 GLN A 179
LEU A 183
SER A 182
ASP A 249
 None
 0.83A 4qtuD-5uakA:
undetectable		 4qtuD-5uakA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ARG A1048
THR A1086
TRP A1089
 None
 1.20A 4ug5A-5uakA:
undetectable		 4ug5A-5uakA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ARG A1048
THR A1086
TRP A1089
 None
 1.10A 4uglA-5uakA:
undetectable		 4uglA-5uakA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 LEU A 935
ILE A 942
HIS A 939
VAL A 938
 None
 1.21A 4xyzA-5uakA:
undetectable		 4xyzA-5uakA:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 LEU A 293
ARG A 251
ARG A 258
 None
 0.79A 4yiaB-5uakA:
undetectable		 4yiaB-5uakA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 5 GLN A1352
HIS A1350
ILE A1384
ILE A1383
 None
 1.24A 5dnuA-5uakA:
undetectable		 5dnuA-5uakA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 5 GLN A1352
HIS A1350
ILE A1384
ILE A1383
 None
 1.19A 5dnvA-5uakA:
undetectable		 5dnvA-5uakA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ARG A1048
THR A1086
TRP A1089
 None
 1.17A 5g6cA-5uakA:
undetectable		 5g6cA-5uakA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		3 / 3 ILE A 255
MET A 245
ASP A 985
 None
 0.71A 5h2uA-5uakA:
undetectable		 5h2uA-5uakA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 5 PHE A1090
ASN A  48
GLN A 151
ASP A  47
 None
 1.34A 5kpcA-5uakA:
undetectable		 5kpcA-5uakA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 6 ARG A 933
ALA A 928
LEU A 926
TYR A 919
 None
 0.88A 5phhA-5uakA:
undetectable		 5phhA-5uakA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY A1123
ILE A 105
GLY A1130
ILE A1131
VAL A1114
 None
 0.93A 6dj1B-5uakA:
undetectable		 6dj1B-5uakA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 GLY A1123
ILE A 105
GLY A1130
ILE A1131
VAL A1114
 None
 0.90A 6dj2B-5uakA:
undetectable		 6dj2B-5uakA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 6 GLY A 144
LEU A 145
VAL A  43
PHE A  77
 None
 0.93A 6h7lA-5uakA:
1.6		 6h7lA-5uakA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 6 GLY A 144
LEU A 145
VAL A  43
PHE A  77
 None
 0.92A 6h7lB-5uakA:
1.9		 6h7lB-5uakA:
4.39