SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 8 HIS A 143
GLY A 186
GLY A 141
ASP A 121
 EDO  A 509 ( 3.5A)
None
None
None
 0.78A 1aegA-5uamA:
undetectable		 1aegA-5uamA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 TRP A 413
VAL A 410
TRP A 414
 None
 1.00A 1gmkC-5uamA:
undetectable
1gmkD-5uamA:
undetectable		 1gmkC-5uamA:
4.30
1gmkD-5uamA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 LYS A 444
ASP A 131
ASP A 219
 None
 1.08A 2br4A-5uamA:
undetectable		 2br4A-5uamA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 7 THR A 318
LEU A 307
VAL A 309
VAL A 259
 None
 0.94A 2cppA-5uamA:
undetectable		 2cppA-5uamA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_E_CUE801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 4 LEU A 111
HIS A 158
HIS A 159
HIS A 143
 None
EDO  A 509 (-2.9A)
None
EDO  A 509 ( 3.5A)
 1.32A 2oqeE-5uamA:
undetectable		 2oqeE-5uamA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 8 LYS A 432
TYR A 466
LYS A 464
PRO A  84
 None
 1.46A 3bjwD-5uamA:
undetectable		 3bjwD-5uamA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 MET A 194
MET A 128
PHE A 202
 None
 1.33A 3gn8A-5uamA:
undetectable		 3gn8A-5uamA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 HIS A 159
HIS A 143
HIS A 158
 None
EDO  A 509 ( 3.5A)
EDO  A 509 (-2.9A)
 0.75A 3mihA-5uamA:
undetectable		 3mihA-5uamA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 12 TYR A 188
TYR A 246
ALA A 207
GLY A 186
HIS A 123
 EDO  A 511 ( 3.0A)
EDO  A 511 ( 3.8A)
EDO  A 509 (-3.0A)
None
PO4  A 503 (-3.7A)
 1.33A 3ou7C-5uamA:
undetectable		 3ou7C-5uamA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 HIS A 278
HIS A 264
HIS A 208
 EDO  A 507 (-2.9A)
ZN  A 502 (-3.2A)
ZN  A 502 ( 3.1A)
 0.59A 3qpkA-5uamA:
undetectable		 3qpkA-5uamA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 HIS A 278
HIS A 264
HIS A 208
 EDO  A 507 (-2.9A)
ZN  A 502 (-3.2A)
ZN  A 502 ( 3.1A)
 0.56A 3qpkB-5uamA:
undetectable		 3qpkB-5uamA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 12 GLY A  57
GLY A 462
ASP A  87
GLY A  59
PHE A 120
 None
 1.05A 3sglA-5uamA:
undetectable		 3sglA-5uamA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 5 PRO A 227
ILE A 257
TRP A 297
PHE A 203
 None
 1.35A 3topB-5uamA:
0.2		 3topB-5uamA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 10 TYR A 188
ILE A  64
TYR A 246
ASP A 262
ILE A 345
 EDO  A 511 ( 3.0A)
K  A 505 (-4.0A)
EDO  A 511 ( 3.8A)
None
None
 1.26A 3uprA-5uamA:
undetectable		 3uprA-5uamA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 10 TYR A 188
ILE A  64
TYR A 246
ASP A 262
ILE A 345
 EDO  A 511 ( 3.0A)
K  A 505 (-4.0A)
EDO  A 511 ( 3.8A)
None
None
 1.24A 3uprC-5uamA:
undetectable		 3uprC-5uamA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 12 TYR A 188
ILE A  64
TYR A 246
ASP A 262
ILE A 345
 EDO  A 511 ( 3.0A)
K  A 505 (-4.0A)
EDO  A 511 ( 3.8A)
None
None
 1.25A 3vrjA-5uamA:
undetectable
3vrjC-5uamA:
undetectable		 3vrjA-5uamA:
21.14
3vrjC-5uamA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 ASP A 243
ARG A 236
ASP A 315
 None
 0.84A 4fp9D-5uamA:
undetectable		 4fp9D-5uamA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 ARG A 204
HIS A 208
TYR A 188
 PO4  A 503 ( 3.0A)
ZN  A 502 ( 3.1A)
EDO  A 511 ( 3.0A)
 1.27A 4fu8A-5uamA:
undetectable		 4fu8A-5uamA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 ARG A 204
HIS A 208
TYR A 188
 PO4  A 503 ( 3.0A)
ZN  A 502 ( 3.1A)
EDO  A 511 ( 3.0A)
 1.35A 4fu9A-5uamA:
undetectable		 4fu9A-5uamA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 TYR A 188
HIS A 208
ARG A 204
 EDO  A 511 ( 3.0A)
ZN  A 502 ( 3.1A)
PO4  A 503 ( 3.0A)
 1.09A 4htfA-5uamA:
undetectable		 4htfA-5uamA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 8 THR A 318
LEU A 307
VAL A 309
VAL A 259
 None
 0.95A 4l4dA-5uamA:
undetectable		 4l4dA-5uamA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 LYS A 234
ASN A 152
ASP A 243
 None
 0.82A 4o1eA-5uamA:
undetectable		 4o1eA-5uamA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 6 TYR A 140
LYS A 163
LEU A 111
GLU A 110
 None
 1.29A 4z4cA-5uamA:
undetectable		 4z4cA-5uamA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 5 TYR A 140
LYS A 163
LEU A 111
GLU A 110
 None
 1.39A 4z4dA-5uamA:
undetectable		 4z4dA-5uamA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 5 TYR A 140
LYS A 163
LEU A 111
GLU A 110
 None
 1.45A 4z4hA-5uamA:
undetectable		 4z4hA-5uamA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 9 HIS A 159
GLY A 145
GLY A 160
HIS A 143
ASP A 121
 None
None
None
EDO  A 509 ( 3.5A)
None
 1.29A 5f8yB-5uamA:
undetectable		 5f8yB-5uamA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 8 SER A 385
ALA A 344
ASP A 388
SER A 332
 None
 1.12A 5l5fY-5uamA:
undetectable
5l5fZ-5uamA:
undetectable		 5l5fY-5uamA:
18.01
5l5fZ-5uamA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 HIS A 159
HIS A 143
HIS A 123
 None
EDO  A 509 ( 3.5A)
PO4  A 503 (-3.7A)
 0.73A 5oexA-5uamA:
14.3		 5oexA-5uamA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 12 MET A 194
ILE A 192
ASP A 195
ILE A 258
THR A 333
 None
 1.30A 5tiwB-5uamA:
undetectable		 5tiwB-5uamA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 10 TYR A 188
ILE A  64
TYR A 246
ASP A 262
ILE A 345
 EDO  A 511 ( 3.0A)
K  A 505 (-4.0A)
EDO  A 511 ( 3.8A)
None
None
 1.26A 5u98A-5uamA:
undetectable		 5u98A-5uamA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 10 TYR A 188
ILE A  64
TYR A 246
ASP A 262
ILE A 345
 EDO  A 511 ( 3.0A)
K  A 505 (-4.0A)
EDO  A 511 ( 3.8A)
None
None
 1.24A 5u98D-5uamA:
undetectable		 5u98D-5uamA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 8 GLU A 395
HIS A 342
SER A 332
HIS A  67
 None
 1.01A 5y2tB-5uamA:
undetectable		 5y2tB-5uamA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		5 / 12 MET A 194
ILE A 192
ASP A 195
THR A 292
THR A 333
 None
 1.08A 6b54A-5uamA:
undetectable		 6b54A-5uamA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		3 / 3 HIS A 158
HIS A 143
ARG A 204
 EDO  A 509 (-2.9A)
EDO  A 509 ( 3.5A)
PO4  A 503 ( 3.0A)
 0.87A 6b58A-5uamA:
undetectable		 6b58A-5uamA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 5 THR A 187
ARG A 204
GLN A 146
ASP A 115
 PO4  A 503 ( 4.9A)
PO4  A 503 ( 3.0A)
None
None
 1.48A 6ectA-5uamA:
undetectable		 6ectA-5uamA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 5 THR A 187
ARG A 204
GLN A 146
ASP A 115
 PO4  A 503 ( 4.9A)
PO4  A 503 ( 3.0A)
None
None
 1.47A 6ecxA-5uamA:
undetectable		 6ecxA-5uamA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5uam ULVAN LYASE-PL25
(Pseudoalteromona
s
sp.
PLSV) 		4 / 6 LEU A  62
LEU A 467
SER A  80
THR A  77
 None
 0.91A 6f88B-5uamA:
undetectable		 6f88B-5uamA:
10.22