SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 5 THR B 390
THR B 299
HIS B 291
LEU B 213
 None
 1.16A 1d4fC-5uanB:
undetectable		 1d4fC-5uanB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B  84
ASP B  86
CYH B  98
GLY B 100
 ZN  B 501 (-2.2A)
None
ZN  B 501 (-2.3A)
None
 0.84A 1ekjA-5uanB:
undetectable
1ekjB-5uanB:
undetectable		 1ekjA-5uanB:
18.18
1ekjB-5uanB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B  81
ASP B  86
VAL B  83
GLY B 100
 ZN  B 501 (-2.3A)
None
ZN  B 501 ( 4.7A)
None
 0.95A 1ekjA-5uanB:
undetectable
1ekjB-5uanB:
undetectable		 1ekjA-5uanB:
18.18
1ekjB-5uanB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 CYH B  84
ASP B  86
CYH B  98
GLY B 100
 ZN  B 501 (-2.2A)
None
ZN  B 501 (-2.3A)
None
 0.81A 1ekjG-5uanB:
undetectable
1ekjH-5uanB:
undetectable		 1ekjG-5uanB:
18.18
1ekjH-5uanB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
LEU A 276
TRP A 305
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.0A)
None
 1.24A 1errA-5uanA:
21.7		 1errA-5uanA:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.60A 1fbyA-5uanA:
33.3		 1fbyA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
LEU A 326
ALA A 327
VAL A 342
CYH A 432
HIS A 435
 9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
 0.52A 1fbyA-5uanA:
33.3		 1fbyA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.60A 1fbyB-5uanA:
32.4		 1fbyB-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
LEU A 326
ALA A 327
VAL A 342
CYH A 432
HIS A 435
 9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
 0.51A 1fbyB-5uanA:
32.4		 1fbyB-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.57A 1fm6A-5uanA:
33.0		 1fm6A-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		7 / 12 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.24A 1fm6U-5uanA:
33.0		 1fm6U-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.55A 1fm6U-5uanA:
33.0		 1fm6U-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 TRP A 305
VAL A 342
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 None
None
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 1.16A 1fm6U-5uanA:
33.0		 1fm6U-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 1fm9A-5uanA:
33.1		 1fm9A-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.39A 1fm9A-5uanA:
33.1		 1fm9A-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 10 LEU A 309
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
 9CR  A 503 (-3.7A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
 0.53A 1g5yC-5uanA:
25.5		 1g5yC-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.56A 1k74A-5uanA:
33.2		 1k74A-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.40A 1k74A-5uanA:
33.2		 1k74A-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 HIS B 365
GLU A 401
ILE B 356
ILE B 370
ARG B 357
 None
 1.16A 1ki7B-5uanB:
undetectable		 1ki7B-5uanB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 10 GLY B 145
PHE B 105
VAL B  95
GLY B  94
VAL B 144
 None
 1.22A 1pwyE-5uanB:
undetectable		 1pwyE-5uanB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 12 ILE B 370
GLY B 320
ALA B 324
ILE B 325
GLU B 313
 None
 0.78A 1vq1A-5uanB:
undetectable		 1vq1A-5uanB:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
GLN A 275
TRP A 305
ASN A 306
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.56A 1xdkA-5uanA:
34.4		 1xdkA-5uanA:
99.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		12 / 12 PHE B 221
ALA B 225
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ILE B 266
ARG B 269
SER B 280
PHE B 295
LEU B 298
LEU B 407
 REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.1A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
None
None
 0.44A 1xdkB-5uanB:
38.3		 1xdkB-5uanB:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.55A 1xdkE-5uanA:
34.4		 1xdkE-5uanA:
99.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 LEU B 224
PHE B 279
ARG B 387
 REA  B 503 ( 4.0A)
REA  B 503 (-4.4A)
None
 0.50A 1xdkF-5uanB:
38.3		 1xdkF-5uanB:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
CYH A 269
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.50A 1xiuA-5uanA:
30.3		 1xiuA-5uanA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
VAL A 342
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.58A 1xiuB-5uanA:
33.9		 1xiuB-5uanA:
62.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 1xlsA-5uanA:
33.1		 1xlsA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 1xlsB-5uanA:
33.2		 1xlsB-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 1xlsC-5uanA:
33.2		 1xlsC-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 1xlsD-5uanA:
33.2		 1xlsD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ALA A 271
ALA A 272
GLN A 275
ASN A 306
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.63A 2aclA-5uanA:
29.7
2aclE-5uanA:
29.6		 2aclA-5uanA:
100.00
2aclE-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		7 / 12 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.31A 2aclA-5uanA:
29.7
2aclE-5uanA:
29.6		 2aclA-5uanA:
100.00
2aclE-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 10 ALA A 271
ALA A 272
PHE A 313
ARG A 316
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
 1.38A 2aclC-5uanA:
29.8		 2aclC-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 10 ILE A 268
ALA A 271
ALA A 272
GLN A 275
ASN A 306
PHE A 313
ARG A 316
ALA A 327
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.62A 2aclC-5uanA:
29.8		 2aclC-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 11 ILE A 268
ALA A 271
ALA A 272
ASN A 306
LEU A 309
PHE A 313
ARG A 316
ALA A 327
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.69A 2aclE-5uanA:
29.6		 2aclE-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 11 ILE A 268
ALA A 271
ALA A 272
GLN A 275
ASN A 306
LEU A 309
PHE A 313
ARG A 316
ALA A 327
ILE A 345
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
 0.65A 2aclE-5uanA:
29.6		 2aclE-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
ALA A 271
ALA A 272
ASN A 306
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
9CR  A 503 (-3.3A)
 0.87A 2aclG-5uanA:
28.7		 2aclG-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
ASN A 306
LEU A 309
ILE A 310
PHE A 313
LEU A 326
ALA A 327
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
 0.68A 2aclG-5uanA:
28.7		 2aclG-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ARG A 371
ILE A 428
ILE A 345
PHE A 346
ALA A 272
 None
None
None
None
9CR  A 503 (-3.5A)
 1.17A 2j0dA-5uanA:
undetectable		 2j0dA-5uanA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.20A 2jfaA-5uanA:
22.4		 2jfaA-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.03A 2jfaA-5uanA:
22.4		 2jfaA-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
GLY A 429
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.05A 2jfaB-5uanA:
9.8		 2jfaB-5uanA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.03A 2jfaB-5uanA:
9.8		 2jfaB-5uanA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE B 221
CYH B 228
LEU B 262
ARG B 265
ILE B 266
ARG B 269
PHE B 279
SER B 280
GLY B 384
LEU B 391
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
REA  B 503 (-3.9A)
None
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.4A)
None
 0.58A 2lbdA-5uanB:
38.0		 2lbdA-5uanB:
64.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		6 / 12 PHE B 221
LYS B 227
LEU B 262
PHE B 279
GLY B 384
LEU B 391
 REA  B 503 ( 4.8A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 ( 4.4A)
None
 1.13A 2lbdA-5uanB:
38.0		 2lbdA-5uanB:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.20A 2qxsA-5uanA:
22.3		 2qxsA-5uanA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 272
LEU A 276
TRP A 305
LEU A 309
ARG A 316
ILE A 428
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 1.21A 2qxsB-5uanA:
22.3		 2qxsB-5uanA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5uan RETINOIC ACID
RECEPTOR BETA
RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 LEU A 392
MET A 230
MET B 366
 None
 1.03A 2vavF-5uanA:
undetectable		 2vavF-5uanA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 11 PHE B 221
CYH B 228
LEU B 262
ILE B 266
ARG B 269
PHE B 279
SER B 280
PHE B 295
VAL B 388
LEU B 391
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.5A)
None
 0.36A 3a9eB-5uanB:
38.8		 3a9eB-5uanB:
59.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		9 / 12 ALA A 271
GLN A 275
ASN A 306
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 342
CYH A 432
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
None
9CR  A 503 (-3.3A)
 0.84A 3dzuA-5uanA:
32.9		 3dzuA-5uanA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
ALA A 271
GLN A 275
ILE A 310
PHE A 313
ARG A 316
LEU A 326
VAL A 342
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.71A 3dzuA-5uanA:
32.9		 3dzuA-5uanA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
GLN A 275
ASN A 306
SER A 312
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.84A 3dzyA-5uanA:
31.8		 3dzyA-5uanA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		7 / 12 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
 1.32A 3e00A-5uanA:
33.5		 3e00A-5uanA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
ASN A 306
PHE A 313
ARG A 316
ALA A 327
VAL A 342
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
 0.56A 3e00A-5uanA:
33.5		 3e00A-5uanA:
78.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		7 / 10 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
 1.40A 3falA-5uanA:
28.7		 3falA-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 10 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
ALA A 327
VAL A 342
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
 0.64A 3falA-5uanA:
28.7		 3falA-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		8 / 10 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.37A 3falC-5uanA:
29.1		 3falC-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 10 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.59A 3falC-5uanA:
29.1		 3falC-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		7 / 11 ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.26A 3fc6A-5uanA:
29.9		 3fc6A-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 11 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.58A 3fc6A-5uanA:
29.9		 3fc6A-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 VAL A 265
CYH A 269
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
 None
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.58A 3fc6C-5uanA:
30.0		 3fc6C-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ALA A 271
ALA A 272
GLN A 275
TRP A 305
LEU A 309
ARG A 316
LEU A 326
ALA A 327
VAL A 342
ILE A 345
CYH A 432
LEU A 436
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.70A 3h0aA-5uanA:
31.7		 3h0aA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		10 / 12 PHE B 221
ALA B 225
LEU B 259
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
ILE B 403
 REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
None
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.4A)
REA  B 503 ( 4.7A)
 0.60A 3lbdA-5uanB:
37.8		 3lbdA-5uanB:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
LEU A 309
ARG A 316
ILE A 428
GLY A 429
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
None
 1.07A 3q95A-5uanA:
25.5		 3q95A-5uanA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
LEU A 309
ARG A 316
ILE A 428
GLY A 429
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
None
 1.09A 3q95B-5uanA:
24.9		 3q95B-5uanA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 271
ALA A 272
PHE A 313
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.4A)
None
 1.23A 3uvvB-5uanA:
34.4		 3uvvB-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
VAL A 342
ILE A 345
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 ( 4.8A)
 0.55A 3uvvB-5uanA:
34.4		 3uvvB-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 12 ILE A 268
ALA A 271
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
VAL A 342
ILE A 345
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
None
9CR  A 503 (-3.3A)
 0.70A 3uvvB-5uanA:
34.4		 3uvvB-5uanA:
66.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 11 PHE B 221
CYH B 228
LEU B 259
LEU B 262
ILE B 263
ARG B 269
PHE B 279
SER B 280
LEU B 298
LEU B 391
ILE B 403
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
None
REA  B 503 (-3.9A)
REA  B 503 (-4.4A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
None
None
REA  B 503 ( 4.7A)
 0.40A 4dm8A-5uanB:
38.5		 4dm8A-5uanB:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 349
CYH A 432
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.52A 4k6iA-5uanA:
34.4		 4k6iA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 11 ILE A 268
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.57A 4nqaA-5uanA:
33.2		 4nqaA-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		9 / 12 ILE A 268
ALA A 271
ALA A 272
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.72A 4nqaH-5uanA:
33.3		 4nqaH-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		9 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
9CR  A 503 ( 4.8A)
 0.62A 4nqaH-5uanA:
33.3		 4nqaH-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		9 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
LEU A 326
ALA A 327
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 ( 4.8A)
 0.46A 4nqaH-5uanA:
33.3		 4nqaH-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		9 / 12 ILE A 268
ALA A 271
ALA A 272
PHE A 313
ARG A 316
LEU A 326
ALA A 327
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.64A 4nqaH-5uanA:
33.3		 4nqaH-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		9 / 12 ILE A 268
ALA A 271
ALA A 272
PHE A 313
LEU A 326
ALA A 327
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-4.7A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.50A 4nqaH-5uanA:
33.3		 4nqaH-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 10 LEU B 348
HIS B 188
LEU B 321
ALA B 324
LEU B 239
 None
 1.23A 4p65A-5uanB:
undetectable
4p65B-5uanB:
undetectable
4p65F-5uanB:
undetectable
4p65H-5uanB:
undetectable		 4p65A-5uanB:
4.66
4p65B-5uanB:
6.25
4p65F-5uanB:
6.25
4p65H-5uanB:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 11 ALA A 272
LEU A 309
ARG A 316
ILE A 428
GLY A 429
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
None
 1.10A 4pxmB-5uanA:
25.5		 4pxmB-5uanA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		4 / 8 PHE B 305
THR B 319
ASP B 315
ASP B 316
 None
 1.30A 4qb9D-5uanB:
undetectable		 4qb9D-5uanB:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		3 / 3 MET B 314
GLU B 318
LEU B 322
 None
 0.46A 4v2oB-5uanB:
1.1		 4v2oB-5uanB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		4 / 7 PHE A 439
LEU A 436
VAL A 265
PHE A 346
 None
9CR  A 503 ( 4.8A)
None
None
 1.04A 4wnvD-5uanA:
undetectable		 4wnvD-5uanA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
ASP A 273
TRP A 305
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.25A 4xi3A-5uanA:
22.3		 4xi3A-5uanA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 272
ASP A 273
TRP A 305
LEU A 309
ARG A 316
LEU A 436
 9CR  A 503 (-3.5A)
None
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
9CR  A 503 ( 4.8A)
 1.21A 4xi3B-5uanA:
22.3		 4xi3B-5uanA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		6 / 12 ALA A 272
TRP A 305
LEU A 309
ARG A 316
ILE A 428
GLY A 429
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
None
 1.10A 4xi3B-5uanA:
22.3		 4xi3B-5uanA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ALA A 272
TRP A 305
LEU A 309
ARG A 316
GLY A 429
 9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-3.0A)
None
 0.99A 4xi3C-5uanA:
21.8		 4xi3C-5uanA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 TYR A 147
LYS A 160
LYS A 156
 None
 0.83A 5dbyA-5uanA:
undetectable		 5dbyA-5uanA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5uan RETINOIC ACID
RECEPTOR BETA
RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		5 / 12 ASP B 376
LEU A 375
SER A 380
LEU A 308
ARG A 421
 None
 1.29A 5hnxB-5uanB:
undetectable		 5hnxB-5uanB:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 11 ILE A 268
GLN A 275
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.64A 5ji0A-5uanA:
32.7		 5ji0A-5uanA:
91.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE B 367
LEU B 371
LEU A 420
ALA A 416
ILE B 325
 None
 1.01A 5ljeA-5uanB:
undetectable		 5ljeA-5uanB:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		11 / 12 TRP B 218
PHE B 221
ALA B 225
LEU B 262
ILE B 266
ARG B 269
SER B 280
PHE B 295
GLY B 384
LEU B 391
ILE B 403
 None
REA  B 503 ( 4.8A)
REA  B 503 (-3.8A)
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.4A)
None
REA  B 503 ( 4.7A)
 0.55A 5m24A-5uanB:
37.8		 5m24A-5uanB:
62.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 10 PRO B 401
MET B 399
ILE B 395
SER B 222
GLU B 223
 None
 1.46A 5tixB-5uanB:
undetectable		 5tixB-5uanB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 12 ALA B 187
ARG B 185
PHE B 235
GLY B 320
ILE B 325
 None
 1.20A 5ul4A-5uanB:
undetectable		 5ul4A-5uanB:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
TRP A 305
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
None
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.53A 5z12B-5uanA:
34.4		 5z12B-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 GLN A 275
ILE A 345
HIS A 435
 9CR  A 503 (-3.8A)
None
None
 0.43A 5z12B-5uanA:
34.4		 5z12B-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.68A 5z12C-5uanA:
33.3		 5z12C-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		8 / 12 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.34A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
TRP A 305
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
None
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.60A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		3 / 3 ASN A 306
VAL A 342
HIS A 435
 None
 0.30A 6a5yD-5uanA:
34.7		 6a5yD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 ( 4.8A)
 0.45A 6a5zD-5uanA:
34.6		 6a5zD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		10 / 12 ILE A 268
ALA A 271
ALA A 272
ILE A 310
PHE A 313
ARG A 316
LEU A 326
ALA A 327
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 ( 4.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.52A 6a5zD-5uanA:
34.6		 6a5zD-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		8 / 12 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
 1.40A 6a5zL-5uanA:
34.4		 6a5zL-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		12 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
LEU A 326
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.58A 6a5zL-5uanA:
34.4		 6a5zL-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		7 / 12 ALA A 271
ALA A 272
GLN A 275
PHE A 313
ARG A 316
ALA A 327
ILE A 428
 9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
 1.46A 6a60D-5uanA:
34.5		 6a60D-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ALA A 327
ILE A 345
CYH A 432
HIS A 435
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
None
9CR  A 503 ( 4.8A)
 0.59A 6a60D-5uanA:
34.5		 6a60D-5uanA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uan RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens) 		11 / 12 ILE A 268
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
ALA A 327
ILE A 345
CYH A 432
LEU A 436
 9CR  A 503 (-4.0A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
9CR  A 503 ( 4.8A)
 0.69A 6a60D-5uanA:
34.5		 6a60D-5uanA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens) 		5 / 12 PHE B 104
GLY B 145
VAL B  95
GLY B 103
GLY B 100
 None
 1.21A 6brdB-5uanB:
undetectable		 6brdB-5uanB:
11.84