SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ub8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.22A 1jhoA-5ub8A:
undetectable		 1jhoA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.23A 1jhrA-5ub8A:
undetectable		 1jhrA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.24A 1l5kA-5ub8A:
undetectable		 1l5kA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.24A 1l5lA-5ub8A:
undetectable		 1l5lA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 9 THR A  71
GLY A  73
GLY A  27
GLU A  75
ARG A  76
 None
ZN  A 302 ( 4.7A)
GDP  A 301 (-3.1A)
GDP  A 301 ( 4.8A)
None
 1.23A 1l5mA-5ub8A:
undetectable		 1l5mA-5ub8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 TRP A 109
THR A  71
TYR A  84
 None
 1.16A 2a3aA-5ub8A:
undetectable		 2a3aA-5ub8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 TRP A 109
THR A  71
TYR A  84
 None
 1.20A 2a3aB-5ub8A:
3.2		 2a3aB-5ub8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 TRP A 109
THR A  71
TYR A  84
 None
 1.20A 2a3bA-5ub8A:
2.9		 2a3bA-5ub8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 8 TYR A  95
GLU A 156
PHE A 154
VAL A 106
 None
 0.78A 2fl5E-5ub8A:
undetectable
2fl5F-5ub8A:
undetectable		 2fl5E-5ub8A:
24.58
2fl5F-5ub8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 ASP A 166
PHE A 169
LEU A 173
 None
 0.43A 2zi9A-5ub8A:
4.9		 2zi9A-5ub8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 GLY A  87
TRP A  69
VAL A  19
 None
 0.61A 3n62B-5ub8A:
undetectable		 3n62B-5ub8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 GLY A  87
TRP A  69
VAL A  19
 None
 0.63A 3n65B-5ub8A:
undetectable		 3n65B-5ub8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 GLY A  87
TRP A  69
VAL A  19
 None
 0.61A 3n66B-5ub8A:
undetectable		 3n66B-5ub8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 LYS A 111
GLU A 112
TRP A 109
 ZN  A 303 ( 4.5A)
ZN  A 303 (-2.6A)
None
 1.40A 3v4tH-5ub8A:
undetectable		 3v4tH-5ub8A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 8 ASN A 128
ALA A 157
SER A 158
LEU A  31
 GDP  A 301 (-3.4A)
None
GDP  A 301 (-3.4A)
None
 1.16A 4ijiF-5ub8A:
undetectable		 4ijiF-5ub8A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 6 LEU A 113
LEU A 110
GLU A 112
ILE A  93
 None
None
ZN  A 303 (-2.6A)
None
 0.97A 4ww7A-5ub8A:
undetectable		 4ww7A-5ub8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 7 ALA A 157
ASP A  70
GLY A  22
GLU A  75
 None
ZN  A 302 ( 3.9A)
None
GDP  A 301 ( 4.8A)
 0.82A 5bs8A-5ub8A:
undetectable
5bs8B-5ub8A:
3.7
5bs8C-5ub8A:
undetectable		 5bs8A-5ub8A:
19.14
5bs8B-5ub8A:
21.19
5bs8C-5ub8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 7 ALA A 157
ASP A  70
GLY A  22
GLU A  75
 None
ZN  A 302 ( 3.9A)
None
GDP  A 301 ( 4.8A)
 0.84A 5btdA-5ub8A:
undetectable
5btdB-5ub8A:
3.6
5btdC-5ub8A:
undetectable		 5btdA-5ub8A:
19.14
5btdB-5ub8A:
21.19
5btdC-5ub8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 7 ALA A 157
ASP A  70
GLY A  22
GLU A  75
 None
ZN  A 302 ( 3.9A)
None
GDP  A 301 ( 4.8A)
 0.87A 5btdA-5ub8A:
undetectable
5btdC-5ub8A:
undetectable
5btdD-5ub8A:
3.2		 5btdA-5ub8A:
19.14
5btdC-5ub8A:
19.14
5btdD-5ub8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		4 / 8 ASP A  70
LEU A  20
THR A  71
VAL A  26
 ZN  A 302 ( 3.9A)
None
None
GDP  A 301 (-4.1A)
 1.22A 5ov9B-5ub8A:
undetectable		 5ov9B-5ub8A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		3 / 3 GLY A  87
TRP A  69
VAL A  19
 None
 0.63A 5vuoB-5ub8A:
undetectable		 5vuoB-5ub8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN
(Candida
albicans) 		5 / 12 ILE A 121
ILE A 176
ILE A  93
VAL A 126
ILE A 123
 None
 0.85A 6emuC-5ub8A:
2.1		 6emuC-5ub8A:
20.60