SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ubk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 8 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.73A 1f5lA-5ubkA:
undetectable		 1f5lA-5ubkA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.90A 1jnoA-5ubkA:
undetectable		 1jnoA-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.90A 1jnoB-5ubkA:
undetectable		 1jnoB-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.87A 1jo4A-5ubkA:
undetectable		 1jo4A-5ubkA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.87A 1jo4B-5ubkA:
undetectable		 1jo4B-5ubkA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.05A 1kiaA-5ubkA:
undetectable		 1kiaA-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.06A 1kiaB-5ubkA:
undetectable		 1kiaB-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.06A 1kiaC-5ubkA:
undetectable		 1kiaC-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.06A 1nbhB-5ubkA:
undetectable		 1nbhB-5ubkA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.11A 1nbiA-5ubkA:
undetectable		 1nbiA-5ubkA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 451
GLY A 478
VAL A 475
ALA A   1
GLY A 454
 None
None
None
83M  A 801 (-3.0A)
None
 1.10A 1nbiB-5ubkA:
undetectable		 1nbiB-5ubkA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.89A 1ng8A-5ubkA:
undetectable		 1ng8A-5ubkA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.89A 1ng8B-5ubkA:
undetectable		 1ng8B-5ubkA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 170
LEU A 260
ALA A 191
LEU A  64
 None
 1.07A 1nh8A-5ubkA:
undetectable		 1nh8A-5ubkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.89A 1nrmA-5ubkA:
undetectable		 1nrmA-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.89A 1nrmB-5ubkA:
undetectable		 1nrmB-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.83A 1nruA-5ubkA:
undetectable		 1nruA-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 147
VAL A 133
TRP A 140
 None
 0.83A 1nruB-5ubkA:
undetectable		 1nruB-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 594
TRP A  26
THR A 515
TYR A 587
 None
 1.38A 1qvuA-5ubkA:
undetectable		 1qvuA-5ubkA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 542
ALA A 559
ILE A 583
GLY A 659
ILE A 561
 None
 0.96A 1sdvA-5ubkA:
undetectable		 1sdvA-5ubkA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.76A 1tnlA-5ubkA:
undetectable		 1tnlA-5ubkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 MET A 377
LEU A 418
LEU A 338
LEU A 336
GLY A 402
 None
 1.09A 2j7xA-5ubkA:
undetectable		 2j7xA-5ubkA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.76A 2otvA-5ubkA:
undetectable		 2otvA-5ubkA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 591
ARG A  31
ASP A 513
 None
 1.00A 2qe6B-5ubkA:
undetectable		 2qe6B-5ubkA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 185
ASN A 155
ARG A 157
 None
 0.97A 2qeuB-5ubkA:
undetectable		 2qeuB-5ubkA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 SER A 503
TYR A 511
HIS A 510
 None
 0.73A 2r2vD-5ubkA:
undetectable		 2r2vD-5ubkA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 GLN A  34
THR A 479
TRP A 523
 None
 0.79A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 483
THR A 189
TRP A 162
 None
None
83M  A 801 (-4.4A)
 1.05A 2rctA-5ubkA:
undetectable		 2rctA-5ubkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 635
ARG A 693
ARG A 690
ASP A 686
 None
 1.33A 2rhmD-5ubkA:
undetectable		 2rhmD-5ubkA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 8 GLN A 203
ASP A  71
SER A 204
SER A  73
 None
 1.21A 2xz5C-5ubkA:
undetectable
2xz5D-5ubkA:
undetectable		 2xz5C-5ubkA:
14.37
2xz5D-5ubkA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 600
ARG A 603
ILE A 599
TYR A 609
 None
 1.16A 2yfbB-5ubkA:
undetectable		 2yfbB-5ubkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 323
ASN A   2
HIS A  23
ALA A 463
 None
 1.14A 3frqA-5ubkA:
undetectable		 3frqA-5ubkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 323
ASN A  21
HIS A  23
ALA A 463
 None
 1.29A 3frqA-5ubkA:
undetectable		 3frqA-5ubkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  23
PHE A 518
GLN A 440
PRO A 452
 None
 1.35A 3gclA-5ubkA:
undetectable		 3gclA-5ubkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 474
HIS A 472
THR A 443
 None
 0.72A 3hkuA-5ubkA:
undetectable		 3hkuA-5ubkA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		6 / 10 ALA A 253
GLY A 183
ILE A 184
SER A  73
VAL A 288
LEU A 256
 None
 1.34A 3ogpA-5ubkA:
undetectable		 3ogpA-5ubkA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 542
ALA A 559
ILE A 583
GLY A 659
ILE A 561
 None
 1.05A 3oxwB-5ubkA:
undetectable		 3oxwB-5ubkA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  52
PRO A  54
VAL A  55
ASN A  57
LEU A 688
 None
None
None
83M  A 801 ( 4.0A)
None
 1.09A 3p2kC-5ubkA:
undetectable		 3p2kC-5ubkA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 SER A 327
VAL A 325
GLY A 456
GLY A 454
 None
None
83M  A 801 (-4.8A)
None
 0.74A 3rxfA-5ubkA:
undetectable		 3rxfA-5ubkA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 206
HIS A  75
SER A 204
THR A 251
 None
 1.08A 3tj7A-5ubkA:
undetectable
3tj7B-5ubkA:
undetectable		 3tj7A-5ubkA:
13.38
3tj7B-5ubkA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 206
HIS A  75
SER A 204
THR A 251
 None
 1.04A 3tj7C-5ubkA:
undetectable
3tj7D-5ubkA:
undetectable		 3tj7C-5ubkA:
13.38
3tj7D-5ubkA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 206
HIS A  75
SER A 204
THR A 251
 None
 1.07A 3tj7C-5ubkA:
undetectable
3tj7D-5ubkA:
undetectable		 3tj7C-5ubkA:
13.38
3tj7D-5ubkA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 7 TRP A 239
ARG A 149
GLY A 129
PRO A 130
 None
 1.14A 3ucbB-5ubkA:
undetectable		 3ucbB-5ubkA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 680
LEU A 691
LEU A 594
THR A 672
PHE A 663
 None
 1.32A 3vhuA-5ubkA:
undetectable		 3vhuA-5ubkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 MET A 377
LEU A 418
LEU A 338
LEU A 336
GLY A 402
 None
 1.15A 4j26A-5ubkA:
undetectable		 4j26A-5ubkA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 695
GLY A 702
PRO A 130
LEU A 708
ASN A 152
 83M  A 801 ( 4.4A)
None
None
None
None
 1.21A 4x61A-5ubkA:
undetectable		 4x61A-5ubkA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbC-5ubkA:
42.0		 4yfbC-5ubkA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbF-5ubkA:
42.1		 4yfbF-5ubkA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.51A 4yfbI-5ubkA:
36.9		 4yfbI-5ubkA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		8 / 12 PRO A  22
PHE A  32
ILE A  58
HIS A  68
VAL A  70
TRP A 162
TRP A 186
VAL A 187
 83M  A 801 ( 4.9A)
None
None
83M  A 801 ( 4.7A)
83M  A 801 (-4.8A)
83M  A 801 (-4.4A)
None
None
 0.54A 4yfbL-5ubkA:
41.5		 4yfbL-5ubkA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 418
ARG A 415
GLU A 426
TYR A 372
LEU A 355
 None
 1.21A 5czyA-5ubkA:
undetectable		 5czyA-5ubkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 11 MET A 377
LEU A 418
LEU A 338
LEU A 336
GLY A 402
 None
 1.12A 5dxgB-5ubkA:
undetectable		 5dxgB-5ubkA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 492
GLY A  47
PHE A  60
HIS A  36
ASP A  44
 None
 1.33A 5eeiA-5ubkA:
undetectable		 5eeiA-5ubkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 492
GLY A  47
PHE A  60
HIS A  36
ASP A  44
 None
 1.32A 5eeiB-5ubkA:
undetectable		 5eeiB-5ubkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 TYR A  79
LEU A 287
PRO A 207
LEU A 213
 None
 1.24A 5eshA-5ubkA:
undetectable		 5eshA-5ubkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 163
LEU A  43
ARG A 577
GLY A 580
ILE A 583
 None
 1.00A 5ifuA-5ubkA:
undetectable		 5ifuA-5ubkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  37
ALA A 586
ILE A 544
GLY A 659
ILE A 571
 None
 0.97A 5kr1A-5ubkA:
undetectable		 5kr1A-5ubkA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 8 SER A 303
ARG A 304
GLN A 401
ASP A 398
 None
 1.28A 5vunA-5ubkA:
undetectable		 5vunA-5ubkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 TRP A 134
LEU A 138
VAL A 132
LEU A  78
 None
 1.12A 5xooB-5ubkA:
undetectable		 5xooB-5ubkA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 703
VAL A 697
TRP A 186
THR A 692
 None
 1.48A 6cduA-5ubkA:
undetectable
6cduB-5ubkA:
undetectable		 6cduA-5ubkA:
18.17
6cduB-5ubkA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
(Pseudomonas
aeruginosa) 		4 / 6 THR A 525
MET A  46
THR A 564
LEU A 517
 None
 1.21A 6mvxA-5ubkA:
undetectable
6mvxB-5ubkA:
undetectable
6mvxC-5ubkA:
undetectable		 6mvxA-5ubkA:
17.16
6mvxB-5ubkA:
17.16
6mvxC-5ubkA:
17.16