SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ubm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 9 ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
 None
 0.59A 1bcuH-5ubmA:
32.9		 1bcuH-5ubmA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 9 HIS A 475
ASP A 626
SER A 632
TRP A 655
GLY A 663
 None
 0.55A 1dwcH-5ubmA:
31.5		 1dwcH-5ubmA:
35.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		7 / 12 HIS A 475
ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
 None
 0.71A 1etrH-5ubmA:
31.3		 1etrH-5ubmA:
34.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 8 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 656
GLY A 663
 None
 0.41A 1f5lA-5ubmA:
30.5		 1f5lA-5ubmA:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 6 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 656
GLY A 663
 None
 0.42A 1tnlA-5ubmA:
11.9		 1tnlA-5ubmA:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ILE A 439
ALA A 619
GLY A 621
GLY A 660
PHE A 636
 None
 1.17A 2okcB-5ubmA:
undetectable		 2okcB-5ubmA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 6 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 656
GLY A 663
 None
 0.46A 2otvA-5ubmA:
11.7		 2otvA-5ubmA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 12 GLY A 571
GLY A 462
GLY A 633
GLY A 630
THR A 472
LEU A 471
 None
 1.41A 2oxtD-5ubmA:
undetectable		 2oxtD-5ubmA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		7 / 12 ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
TYR A 665
 None
 0.50A 2p16A-5ubmA:
31.6		 2p16A-5ubmA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.43A 2q7iA-5ubmA:
undetectable		 2q7iA-5ubmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7kA-5ubmA:
undetectable		 2q7kA-5ubmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.42A 2q7lA-5ubmA:
undetectable		 2q7lA-5ubmA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		7 / 12 ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
TYR A 665
 None
 0.51A 2w26A-5ubmA:
31.5		 2w26A-5ubmA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.40A 2yloA-5ubmA:
undetectable		 2yloA-5ubmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 11 THR A 678
ILE A 510
LEU A 471
ASN A 466
ILE A 530
 None
 1.28A 3a50B-5ubmA:
undetectable		 3a50B-5ubmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 THR A 678
ILE A 510
LEU A 471
ASN A 466
ILE A 530
 None
 1.24A 3a50E-5ubmA:
undetectable		 3a50E-5ubmA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 11 HIS A 511
PRO A 512
TRP A 674
LYS A 677
GLU A 467
 None
 1.39A 3bf6H-5ubmA:
32.1		 3bf6H-5ubmA:
35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 SER A 632
ALA A 460
ASN A 480
HIS A 475
VAL A 476
 None
 1.14A 3f8wA-5ubmA:
undetectable		 3f8wA-5ubmA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		7 / 11 HIS A 475
ASP A 626
SER A 627
SER A 632
TRP A 655
GLY A 656
GLY A 663
 None
 0.52A 3gy3A-5ubmA:
11.7		 3gy3A-5ubmA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 GLY A 569
GLY A 571
ALA A 444
THR A 490
LEU A 582
 None
 1.17A 3p2kB-5ubmA:
undetectable		 3p2kB-5ubmA:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 6 SER A 627
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
 None
 0.53A 3rxfA-5ubmA:
12.6		 3rxfA-5ubmA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 5 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 663
 None
 0.51A 3rxhA-5ubmA:
11.7		 3rxhA-5ubmA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 LEU A 471
LEU A 532
VAL A 672
MET A 676
THR A 666
 None
 1.41A 3zqtA-5ubmA:
undetectable		 3zqtA-5ubmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 ASN A 615
THR A 666
LEU A 652
ALA A 474
HIS A 511
 None
 1.38A 4ejwA-5ubmA:
undetectable		 4ejwA-5ubmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
GIGASTASIN
(Homo
sapiens;
Haementeria
ghilianii) 		5 / 11 LEU A 664
GLY A 656
PHE I  62
TYR A 665
ALA A 619
 None
 0.94A 4fogD-5ubmA:
undetectable		 4fogD-5ubmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
GIGASTASIN
(Haementeria
ghilianii;
Homo
sapiens) 		5 / 12 LEU A 664
GLY A 656
PHE I  62
TYR A 665
ALA A 619
 None
 1.03A 4foxD-5ubmA:
undetectable		 4foxD-5ubmA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 HIS A 475
ASP A 626
VAL A 653
TRP A 655
GLY A 663
 None
 0.48A 4hfpD-5ubmA:
31.7		 4hfpD-5ubmA:
35.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 VAL A 668
GLY A 462
ILE A 530
LEU A 532
LEU A 464
 None
 1.04A 4qdjA-5ubmA:
undetectable		 4qdjA-5ubmA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 HIS A 475
VAL A 653
TRP A 655
GLY A 656
GLY A 663
 None
 0.48A 4rn6B-5ubmA:
27.1		 4rn6B-5ubmA:
35.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		5 / 12 SER A 632
ALA A 473
ASP A 529
PHE A 526
THR A 666
 None
 1.22A 4xt8A-5ubmA:
undetectable		 4xt8A-5ubmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
GIGASTASIN
(Homo
sapiens;
Haementeria
ghilianii) 		3 / 3 ASP I  60
ARG A 572
ARG I  65
 None
 0.97A 5eajB-5ubmI:
undetectable		 5eajB-5ubmI:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens) 		6 / 12 GLY A 571
GLY A 462
GLY A 633
GLY A 630
THR A 472
VAL A 470
 None
 1.25A 5eiwC-5ubmA:
undetectable		 5eiwC-5ubmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5ubm GIGASTASIN
(Haementeria
ghilianii) 		5 / 10 GLY I  71
GLY I 108
SER I 107
ARG I 109
GLU I 111
 None
 1.24A 5hwkA-5ubmI:
undetectable		 5hwkA-5ubmI:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5ubm GIGASTASIN
(Haementeria
ghilianii) 		5 / 10 GLY I  71
GLY I 108
SER I 107
ARG I 109
GLU I 111
 None
 1.24A 5hwkB-5ubmI:
undetectable		 5hwkB-5ubmI:
19.35