SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ubp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 544
LEU A 532
LEU A 342
LEU A 345
 None
 0.91A 1errA-5ubpA:
undetectable		 1errA-5ubpA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 508
ILE A 498
ILE A 500
PHE A 474
LEU A 477
 None
 1.22A 1xdkB-5ubpA:
undetectable		 1xdkB-5ubpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 272
LEU A 265
MET A 203
 None
 0.81A 1ya3B-5ubpA:
undetectable		 1ya3B-5ubpA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 256
ILE A 290
PHE A 282
GLY A 281
LEU A 317
 None
 1.30A 2nyrB-5ubpA:
undetectable		 2nyrB-5ubpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 272
TRP A 284
TYR A 219
 None
 0.98A 3aicG-5ubpA:
undetectable		 3aicG-5ubpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 192
GLU A 117
SER A 186
 None
 0.69A 3p2kA-5ubpA:
undetectable		 3p2kA-5ubpA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 282
GLU A 208
PRO A 205
ILE A 268
ASN A 271
 None
 1.46A 3rfaA-5ubpA:
undetectable		 3rfaA-5ubpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 282
GLU A 208
PRO A 205
ILE A 268
ASN A 271
 None
 1.38A 4pl1A-5ubpA:
undetectable		 4pl1A-5ubpA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 208
ARG A 211
GLN A 292
 None
 0.90A 4rtbA-5ubpA:
undetectable		 4rtbA-5ubpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 477
ILE A 490
THR A 510
HIS A 469
THR A 464
 None
 1.15A 4ze2A-5ubpA:
undetectable		 4ze2A-5ubpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5ubp LEUCINE PERMEASE
TRANSCRIPTIONAL
REGULATOR
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 171
ARG A 168
PHE A 207
PRO A 205
 None
 1.42A 6fgdA-5ubpA:
undetectable		 6fgdA-5ubpA:
20.64