SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ubv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		3 / 3 ASP A 134
PHE A  91
ASN A 127
 None
 0.71A 1sg9B-5ubvA:
2.1		 1sg9B-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		3 / 3 ASP A 118
TYR A 121
LYS A  80
 None
 1.10A 2othA-5ubvA:
undetectable		 2othA-5ubvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 GLU A 132
PHE A  91
ALA A  60
LEU A  21
ILE A 144
 None
 1.11A 2xkwB-5ubvA:
undetectable		 2xkwB-5ubvA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 206
ILE A 181
GLY A  10
LEU A 207
THR A  50
 None
ADP  A 302 ( 4.4A)
None
None
ADP  A 302 (-4.3A)
 1.16A 3eeyD-5ubvA:
undetectable		 3eeyD-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A 129
ILE A 104
LEU A 107
ASP A 108
PHE A  75
 None
 1.14A 3ko0A-5ubvA:
undetectable
3ko0B-5ubvA:
undetectable
3ko0C-5ubvA:
undetectable
3ko0D-5ubvA:
undetectable		 3ko0A-5ubvA:
21.05
3ko0B-5ubvA:
21.05
3ko0C-5ubvA:
21.05
3ko0D-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 11 PHE A  75
LEU A 107
ASP A 108
LEU A 129
ILE A 104
 None
 1.12A 3ko0A-5ubvA:
undetectable
3ko0B-5ubvA:
undetectable
3ko0I-5ubvA:
undetectable
3ko0J-5ubvA:
undetectable		 3ko0A-5ubvA:
21.05
3ko0B-5ubvA:
21.05
3ko0I-5ubvA:
21.05
3ko0J-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A 129
ILE A 104
LEU A 107
ASP A 108
PHE A  75
 None
 1.18A 3ko0K-5ubvA:
undetectable
3ko0L-5ubvA:
undetectable
3ko0S-5ubvA:
undetectable
3ko0T-5ubvA:
undetectable		 3ko0K-5ubvA:
21.05
3ko0L-5ubvA:
21.05
3ko0S-5ubvA:
21.05
3ko0T-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A 107
ASP A 108
LEU A 129
ILE A 104
PHE A  75
 None
 1.17A 3ko0K-5ubvA:
undetectable
3ko0L-5ubvA:
undetectable
3ko0M-5ubvA:
undetectable
3ko0N-5ubvA:
undetectable		 3ko0K-5ubvA:
21.05
3ko0L-5ubvA:
21.05
3ko0M-5ubvA:
21.05
3ko0N-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A 129
ILE A 104
LEU A 107
ASP A 108
PHE A  75
 None
 1.13A 3ko0M-5ubvA:
undetectable
3ko0N-5ubvA:
undetectable
3ko0O-5ubvA:
undetectable
3ko0P-5ubvA:
undetectable		 3ko0M-5ubvA:
21.05
3ko0N-5ubvA:
21.05
3ko0O-5ubvA:
21.05
3ko0P-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 PHE A  75
LEU A 107
ASP A 108
LEU A 129
ILE A 104
 None
 1.09A 3ko0M-5ubvA:
undetectable
3ko0N-5ubvA:
undetectable
3ko0O-5ubvA:
undetectable
3ko0P-5ubvA:
undetectable		 3ko0M-5ubvA:
21.05
3ko0N-5ubvA:
21.05
3ko0O-5ubvA:
21.05
3ko0P-5ubvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 VAL A  59
ALA A  60
GLY A  61
LEU A  44
TYR A  69
 None
 1.11A 3rc0B-5ubvA:
undetectable		 3rc0B-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A  90
PHE A  91
ILE A 104
LEU A 129
ILE A 144
 None
 1.12A 4nx7A-5ubvA:
undetectable		 4nx7A-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A  90
PHE A  91
ILE A 104
LEU A 129
ILE A 144
 None
 1.10A 4pstA-5ubvA:
undetectable		 4pstA-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 7 LEU A  55
LEU A  44
GLU A  16
LYS A  15
LEU A  18
 None
 1.48A 4wg0L-5ubvA:
undetectable
4wg0M-5ubvA:
undetectable		 4wg0L-5ubvA:
undetectable
4wg0M-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		3 / 3 HIS A 185
HIS A 184
HIS A   9
 ADP  A 302 (-4.4A)
None
None
 0.92A 5oexA-5ubvA:
undetectable		 5oexA-5ubvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 5ubv ATPASE DOMAIN OF
I-AAA PROTEASE
(Thermothelomyces
thermophila) 		5 / 11 ASN A  92
PHE A  91
MET A  70
THR A 125
THR A 131
 None
 1.47A 6hcoA-5ubvA:
3.1
6hcoB-5ubvA:
3.3		 6hcoA-5ubvA:
undetectable
6hcoB-5ubvA:
undetectable