SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ubz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 THR H  73
SER H  52
ASP H  52
SER H  52
 None
 1.13A 2hdnA-5ubzH:
undetectable
2hdnB-5ubzH:
undetectable
2hdnD-5ubzH:
undetectable		 2hdnA-5ubzH:
22.22
2hdnB-5ubzH:
13.65
2hdnD-5ubzH:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  52
THR H  73
SER H  52
ASP H  52
 None
 1.12A 2hdnB-5ubzH:
undetectable
2hdnC-5ubzH:
undetectable
2hdnD-5ubzH:
undetectable		 2hdnB-5ubzH:
13.65
2hdnC-5ubzH:
22.22
2hdnD-5ubzH:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 6 THR H  73
SER H  52
ASP H  52
SER H  52
 None
 1.14A 2hdnI-5ubzH:
undetectable
2hdnJ-5ubzH:
undetectable
2hdnL-5ubzH:
undetectable		 2hdnI-5ubzH:
22.22
2hdnJ-5ubzH:
13.65
2hdnL-5ubzH:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 6 SER H  52
THR H  73
SER H  52
ASP H  52
 None
 1.14A 2hdnJ-5ubzH:
undetectable
2hdnK-5ubzH:
undetectable
2hdnL-5ubzH:
undetectable		 2hdnJ-5ubzH:
13.65
2hdnK-5ubzH:
22.22
2hdnL-5ubzH:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 9 LEU H  20
ILE H 107
GLY H 106
GLY H 104
SER H  79
 None
 1.19A 2qmmA-5ubzH:
undetectable		 2qmmA-5ubzH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5ubz ANTI-HIV1 GP120 MAB
1E12 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 TYR H 144
HIS H 199
LEU H 108
ALA H 167
THR H  87
 None
 1.20A 3jwqB-5ubzH:
undetectable
3jwqC-5ubzH:
undetectable		 3jwqB-5ubzH:
15.81
3jwqC-5ubzH:
15.81