SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 11 ILE A 184
GLY A 113
THR A  93
LEU A 169
ARG A 173
 None
 1.31A 1i7qA-5uc0A:
undetectable		 1i7qA-5uc0A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 10 GLY A 158
VAL A 182
GLY A 181
THR A 174
VAL A 153
 None
 1.33A 1v3qE-5uc0A:
undetectable		 1v3qE-5uc0A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 5 ASP A 119
SER A  85
LEU A 116
GLY A 117
 None
 1.08A 2j2pA-5uc0A:
undetectable
2j2pB-5uc0A:
undetectable		 2j2pA-5uc0A:
21.19
2j2pB-5uc0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 6 ASP A 119
SER A  85
LEU A 116
GLY A 117
 None
 1.04A 2j2pD-5uc0A:
undetectable
2j2pF-5uc0A:
undetectable		 2j2pD-5uc0A:
21.19
2j2pF-5uc0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 12 LEU A  99
TYR A 100
GLU A  45
GLY A  77
LEU A 130
 None
 1.44A 3ou6D-5uc0A:
undetectable		 3ou6D-5uc0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 10 TYR A 132
VAL A  46
TYR A  41
GLY A  73
PHE A  69
 None
 1.39A 4mmcA-5uc0A:
undetectable		 4mmcA-5uc0A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 5 ARG A 179
GLY A 177
ALA A 178
GLY A 181
 None
 0.95A 4u9uA-5uc0A:
undetectable		 4u9uA-5uc0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 5 ARG A 179
GLY A 177
ALA A 178
GLY A 181
 None
 0.90A 4u9uB-5uc0A:
undetectable		 4u9uB-5uc0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 12 GLY A  86
GLY A  84
GLY A 124
LEU A  92
ALA A  87
 None
1PE  A 205 ( 4.3A)
1PE  A 205 ( 4.7A)
None
None
 1.01A 4uciB-5uc0A:
undetectable		 4uciB-5uc0A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 5 GLY A 124
TYR A  94
GLU A  82
ASP A 119
 1PE  A 205 ( 4.7A)
1PE  A 205 (-4.0A)
None
None
 1.31A 4xueA-5uc0A:
undetectable		 4xueA-5uc0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		5 / 12 TYR A 141
ILE A 137
LEU A 134
HIS A 107
GLY A  97
 None
 1.06A 5zwrA-5uc0A:
undetectable		 5zwrA-5uc0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 7 ALA A  43
THR A  42
TYR A  41
VAL A  47
 None
 0.83A 6cduA-5uc0A:
undetectable
6cduE-5uc0A:
undetectable		 6cduA-5uc0A:
18.94
6cduE-5uc0A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		4 / 7 VAL A  47
ALA A  43
THR A  42
TYR A  41
 None
 0.86A 6cduH-5uc0A:
undetectable
6cduI-5uc0A:
undetectable		 6cduH-5uc0A:
18.94
6cduI-5uc0A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5uc0 UNCHARACTERIZED
PROTEIN COG5400
(Brucella
abortus) 		3 / 3 SER A  56
SER A  58
ALA A 178
 None
 0.73A 6dwnC-5uc0A:
undetectable		 6dwnC-5uc0A:
23.42