SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 6 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.35A 2dysA-5uc2A:
undetectable
2dysJ-5uc2A:
undetectable
2dysA-5uc2A:
18.71
2dysJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.37A 2eimJ-5uc2A:
undetectable
2eimJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.26A 2eimJ-5uc2A:
undetectable
2eimJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 5 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.37A 2eimW-5uc2A:
undetectable
2eimW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 6 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.41A 2einN-5uc2A:
undetectable
2einW-5uc2A:
undetectable
2einN-5uc2A:
18.71
2einW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 12 LEU A  33
VAL A  31
LEU A 263
LEU A 250
TYR A  40
None
None
None
None
EDO  A 303 (-4.9A)
1.36A 2prgB-5uc2A:
undetectable
2prgB-5uc2A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 6 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.38A 2zxwA-5uc2A:
undetectable
2zxwJ-5uc2A:
undetectable
2zxwA-5uc2A:
18.71
2zxwJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 6 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.38A 3abmA-5uc2A:
undetectable
3abmJ-5uc2A:
undetectable
3abmA-5uc2A:
18.71
3abmJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 254
MET A 252
THR A 251
LEU A 250
None
1.47A 3ag1J-5uc2A:
undetectable
3ag1J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.30A 3ag2J-5uc2A:
undetectable
3ag2J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.25A 3ag2J-5uc2A:
undetectable
3ag2J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.34A 3ag4J-5uc2A:
undetectable
3ag4J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.24A 3ag4J-5uc2A:
undetectable
3ag4J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 6 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.36A 3asnA-5uc2A:
undetectable
3asnJ-5uc2A:
undetectable
3asnA-5uc2A:
18.71
3asnJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 6 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.37A 3asoA-5uc2A:
undetectable
3asoJ-5uc2A:
undetectable
3asoA-5uc2A:
18.71
3asoJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 LEU A 146
VAL A 136
VAL A 123
ASP A 182
None
1.15A 3fwgA-5uc2A:
undetectable
3fwgA-5uc2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 LEU A 146
VAL A 136
VAL A 123
ASP A 182
None
1.14A 3wrjE-5uc2A:
undetectable
3wrjE-5uc2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 ARG A  37
HIS A  36
LEU A 263
ASP A 267
None
EDO  A 303 (-4.7A)
None
None
1.12A 4cevA-5uc2A:
undetectable
4cevB-5uc2A:
undetectable
4cevA-5uc2A:
21.81
4cevB-5uc2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 ASP A 267
ARG A  37
HIS A  36
LEU A 263
None
None
EDO  A 303 (-4.7A)
None
1.10A 4cevA-5uc2A:
undetectable
4cevC-5uc2A:
undetectable
4cevA-5uc2A:
21.81
4cevC-5uc2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 ARG A  37
HIS A  36
LEU A 263
ASP A 267
None
EDO  A 303 (-4.7A)
None
None
1.11A 4cevD-5uc2A:
undetectable
4cevE-5uc2A:
undetectable
4cevD-5uc2A:
21.81
4cevE-5uc2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 ARG A  37
HIS A  36
LEU A 263
ASP A 267
None
EDO  A 303 (-4.7A)
None
None
1.12A 4cevE-5uc2A:
undetectable
4cevF-5uc2A:
undetectable
4cevE-5uc2A:
21.81
4cevF-5uc2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 8 THR A 219
ALA A 221
THR A 190
VAL A 192
None
0.44A 4ik7B-5uc2A:
undetectable
4ik7B-5uc2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 6 LEU A 146
VAL A 136
VAL A 123
ASP A 182
None
1.09A 4l4cA-5uc2A:
undetectable
4l4cA-5uc2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 12 LEU A  33
VAL A  31
LEU A 263
LEU A 250
TYR A  40
None
None
None
None
EDO  A 303 (-4.9A)
1.38A 4o8fB-5uc2A:
undetectable
4o8fB-5uc2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 7 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.45A 5iy5N-5uc2A:
undetectable
5iy5W-5uc2A:
undetectable
5iy5N-5uc2A:
18.71
5iy5W-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 4 TYR A 235
ARG A 236
THR A 251
LEU A 250
None
1.06A 5wauj-5uc2A:
undetectable
5wauj-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.27A 5wauJ-5uc2A:
undetectable
5wauJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 254
MET A 252
THR A 251
LEU A 250
None
1.41A 5x19J-5uc2A:
undetectable
5x19J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 254
MET A 252
THR A 251
LEU A 250
None
1.43A 5x1bJ-5uc2A:
undetectable
5x1bJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.31A 5x1bW-5uc2A:
undetectable
5x1bW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.32A 5x1bW-5uc2A:
undetectable
5x1bW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 254
MET A 252
THR A 251
LEU A 250
None
1.45A 5x1bW-5uc2A:
undetectable
5x1bW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
5 / 5 TYR A 235
ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.39A 5x1fW-5uc2A:
undetectable
5x1fW-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.27A 5z86J-5uc2A:
undetectable
5z86J-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 ARG A 236
MET A 252
THR A 251
LEU A 250
None
1.41A 6nknJ-5uc2A:
undetectable
6nknJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.39A 6nknJ-5uc2A:
undetectable
6nknJ-5uc2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5uc2 DOMAIN OF UNKNOWN
FUNCTION DUF1849

(Brucella
abortus)
4 / 5 TYR A 235
MET A 252
THR A 251
LEU A 250
None
1.34A 6nknW-5uc2A:
undetectable
6nknW-5uc2A:
14.29