SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 HIS A 303
SER A 191
LEU A 105
GLY A 216
 None
 0.99A 1a4lB-5uc5A:
undetectable		 1a4lB-5uc5A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 12 GLY A 372
VAL A 271
ILE A 254
GLY A 376
ILE A 275
 None
 1.09A 1c6zA-5uc5A:
undetectable		 1c6zA-5uc5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 6 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.18A 1dz4B-5uc5A:
undetectable		 1dz4B-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 12 VAL A 382
LEU A 384
VAL A 188
ALA A 174
ILE A 224
 None
 0.95A 1epbB-5uc5A:
undetectable		 1epbB-5uc5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 THR A 132
GLY A 163
LEU A 263
GLY A 256
 None
 0.75A 1jhaA-5uc5A:
undetectable		 1jhaA-5uc5A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 11 VAL A 170
LEU A 173
ALA A 174
ALA A 178
THR A 145
 None
 0.96A 1jinA-5uc5A:
undetectable		 1jinA-5uc5A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.16A 1t88B-5uc5A:
undetectable		 1t88B-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.16A 2m56A-5uc5A:
undetectable		 2m56A-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 PHE A 265
ILE A 254
PHE A 215
ILE A 275
 None
 0.93A 2qwxA-5uc5A:
undetectable
2qwxB-5uc5A:
undetectable		 2qwxA-5uc5A:
20.10
2qwxB-5uc5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 11 ILE A 223
ALA A 110
LEU A 144
LEU A 150
ILE A 124
 None
 1.09A 2w9sA-5uc5A:
undetectable		 2w9sA-5uc5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 None
 0.65A 2w9sE-5uc5A:
undetectable		 2w9sE-5uc5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 6 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.18A 2zawA-5uc5A:
undetectable		 2zawA-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 6 THR A 169
VAL A 170
GLU A 192
CYH A 190
 None
 1.23A 3b6rB-5uc5A:
undetectable		 3b6rB-5uc5A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.04A 3fhxB-5uc5A:
undetectable		 3fhxB-5uc5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 ASP A 311
LEU A 310
ILE A 275
PRO A 272
 None
 1.11A 3s3vA-5uc5A:
undetectable		 3s3vA-5uc5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 11 VAL A 271
PHE A 215
GLY A 305
LEU A 267
PHE A 265
 None
 1.03A 3t3rA-5uc5A:
undetectable		 3t3rA-5uc5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 SER A 386
THR A 360
GLU A 238
ASP A 227
 None
 0.98A 3tm4A-5uc5A:
2.6		 3tm4A-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 SER A 386
THR A 360
GLU A 238
ASP A 227
 None
 0.99A 3tm4B-5uc5A:
2.6		 3tm4B-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 7 VAL A 271
PHE A 215
GLY A 305
PHE A 265
 None
 0.93A 4ejjB-5uc5A:
undetectable		 4ejjB-5uc5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 7 ILE A 114
LEU A 150
GLY A 149
TYR A 153
 None
 0.90A 4iqqB-5uc5A:
undetectable		 4iqqB-5uc5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 6 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.11A 4kkyX-5uc5A:
undetectable		 4kkyX-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 10 VAL A 222
ASP A 347
LEU A 384
VAL A  19
THR A  24
 None
 1.47A 4kyaC-5uc5A:
undetectable		 4kyaC-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 5 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.19A 4l49A-5uc5A:
undetectable		 4l49A-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		3 / 3 ARG A   8
ASN A 181
ASP A 227
 None
 0.88A 5gwxA-5uc5A:
undetectable		 5gwxA-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 7 ILE A 114
LEU A 150
GLY A 149
TYR A 153
 None
 0.86A 5h3aB-5uc5A:
undetectable		 5h3aB-5uc5A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 9 LEU A 283
ILE A 292
ILE A 301
PHE A 371
VAL A 379
 None
 1.47A 5igzA-5uc5A:
undetectable		 5igzA-5uc5A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 GLU A 238
PRO A 228
GLY A  15
PRO A  16
 None
 1.06A 5kf8A-5uc5A:
undetectable		 5kf8A-5uc5A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		3 / 3 THR A 194
THR A  44
LEU A 209
 None
 0.68A 5m66D-5uc5A:
undetectable		 5m66D-5uc5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 12 TRP A 300
THR A 327
LEU A 324
PHE A 373
THR A 381
 None
 1.26A 5w8aA-5uc5A:
undetectable		 5w8aA-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 7 PHE A 373
GLY A 374
GLY A 376
THR A 132
 None
 0.69A 5ybbB-5uc5A:
undetectable		 5ybbB-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.85A 6c06C-5uc5A:
undetectable		 6c06C-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		5 / 12 LEU A 268
ASP A 207
VAL A 271
LEU A 274
ILE A 275
 None
 1.05A 6ectA-5uc5A:
undetectable		 6ectA-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5uc5 CHS2 CHALCONE
SYNTHASE
(Malus
domestica) 		4 / 8 ILE A 246
GLN A 244
THR A 169
VAL A 170
 None
 0.86A 6fbvC-5uc5A:
undetectable		 6fbvC-5uc5A:
undetectable