SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ucg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		4 / 6 HIS A 637
ASP A 796
ASP A 610
TYR A 612
 None
 1.42A 2lh8A-5ucgA:
undetectable		 2lh8A-5ucgA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		6 / 12 GLY A 629
THR A 679
LEU A 680
GLU A 639
ILE A 626
ASP A 796
 None
 1.35A 2oxtC-5ucgA:
undetectable		 2oxtC-5ucgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		5 / 12 LEU A 651
MET A 615
ILE A 664
LEU A 741
VAL A 802
 None
 1.17A 2po5A-5ucgA:
undetectable		 2po5A-5ucgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		4 / 6 LEU A 651
SER A 691
ASP A 689
GLU A 657
 None
 1.28A 2vn1B-5ucgA:
undetectable		 2vn1B-5ucgA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		5 / 12 ALA A 660
LEU A 651
LEU A 682
LYS A 696
ILE A 644
 None
 1.13A 3hj3B-5ucgA:
undetectable		 3hj3B-5ucgA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		6 / 12 ILE A 793
GLY A 747
GLY A 609
THR A 798
TYR A 612
ILE A 626
 None
 1.47A 3q70A-5ucgA:
undetectable		 3q70A-5ucgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		4 / 5 LYS A 693
TYR A 622
MET A 615
ARG A 500
 None
 1.43A 4bkjB-5ucgA:
undetectable		 4bkjB-5ucgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		5 / 12 PRO A 774
GLY A 738
LEU A 735
ASN A 772
MET A 766
 None
 1.46A 5emlA-5ucgA:
undetectable		 5emlA-5ucgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5ucg STAGE II SPORULATION
PROTEIN E
(Bacillus
subtilis) 		5 / 12 VAL A 802
ALA A 625
ALA A 624
LEU A 682
THR A 700
 None
 1.18A 5igpA-5ucgA:
undetectable		 5igpA-5ucgA:
18.13