SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ucm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 367
ALA A 358
PHE A 357
GLY A 360
 None
 1.29A 1mjoA-5ucmA:
undetectable		 1mjoA-5ucmA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 272
PRO A 273
HIS A 367
ALA A 358
PHE A 357
 None
 1.34A 1mjqI-5ucmA:
undetectable
1mjqJ-5ucmA:
undetectable		 1mjqI-5ucmA:
12.37
1mjqJ-5ucmA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A 201
GLY A 200
GLY A 204
GLY A 206
 None
 0.77A 3bogB-5ucmA:
undetectable
3bogD-5ucmA:
undetectable		 3bogB-5ucmA:
undetectable
3bogD-5ucmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 133
TYR A 181
ILE A 444
 None
 0.64A 3eteA-5ucmA:
undetectable
3eteB-5ucmA:
undetectable		 3eteA-5ucmA:
22.61
3eteB-5ucmA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 113
HIS A 110
THR A 109
TYR A 419
 None
 0.99A 3fhxB-5ucmA:
undetectable		 3fhxB-5ucmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 9 GLN A 456
VAL A 212
ILE A 444
VAL A 446
VAL A  53
 None
 1.38A 3fi0F-5ucmA:
undetectable		 3fi0F-5ucmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 381
VAL A 347
VAL A 292
ALA A 344
 None
 0.87A 3kp6B-5ucmA:
0.5		 3kp6B-5ucmA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   7
LEU A   8
ILE A 527
GLY A 526
LEU A 524
 None
 1.02A 3q95B-5ucmA:
undetectable		 3q95B-5ucmA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 472
LEU A   7
MET A 522
ILE A 525
 None
 0.98A 3rfmA-5ucmA:
undetectable		 3rfmA-5ucmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.18A 4feuF-5ucmA:
3.5		 4feuF-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.14A 4fevB-5ucmA:
2.4		 4fevB-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.20A 4fevD-5ucmA:
3.4		 4fevD-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.19A 4fevF-5ucmA:
3.4		 4fevF-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.14A 4fewB-5ucmA:
3.6		 4fewB-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.19A 4fewD-5ucmA:
undetectable		 4fewD-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.20A 4fewF-5ucmA:
undetectable		 4fewF-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.20A 4fexB-5ucmA:
3.5		 4fexB-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.18A 4gkhB-5ucmA:
2.8		 4gkhB-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.14A 4gkhD-5ucmA:
2.3		 4gkhD-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.17A 4gkhF-5ucmA:
undetectable		 4gkhF-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.21A 4gkhG-5ucmA:
3.4		 4gkhG-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.13A 4gkhJ-5ucmA:
3.4		 4gkhJ-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.19A 4gkiA-5ucmA:
3.6		 4gkiA-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 356
ASN A 372
ASP A 251
GLU A 250
 None
 1.21A 4gkiC-5ucmA:
undetectable		 4gkiC-5ucmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5ucm PROLINE--TRNA LIGASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 182
LYS A 183
SER A 186
 None
 0.74A 6az3P-5ucmA:
undetectable		 6az3P-5ucmA:
9.00