SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uco'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 VAL A 386
LEU A 388
VAL A 191
ALA A 177
ILE A 227
 None
 0.92A 1epbB-5ucoA:
undetectable		 1epbB-5ucoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 GLY A 376
GLY A 171
GLY A 170
VAL A 383
GLY A 309
 None
 0.94A 1n2xB-5ucoA:
undetectable		 1n2xB-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 5 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.06A 1t88B-5ucoA:
undetectable		 1t88B-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 THR A 134
TYR A 163
LEU A 101
MET A 199
 None
 1.44A 1uw6A-5ucoA:
undetectable
1uw6B-5ucoA:
undetectable		 1uw6A-5ucoA:
17.61
1uw6B-5ucoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 THR A 134
TYR A 163
LEU A 101
MET A 199
 None
 1.42A 1uw6D-5ucoA:
undetectable
1uw6E-5ucoA:
undetectable		 1uw6D-5ucoA:
17.61
1uw6E-5ucoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 THR A 134
TYR A 163
LEU A 101
MET A 199
 None
 1.43A 1uw6G-5ucoA:
undetectable
1uw6H-5ucoA:
undetectable		 1uw6G-5ucoA:
17.61
1uw6H-5ucoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 THR A 134
TYR A 163
LEU A 101
MET A 199
 None
 1.41A 1uw6P-5ucoA:
undetectable
1uw6Q-5ucoA:
undetectable		 1uw6P-5ucoA:
17.61
1uw6Q-5ucoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 LEU A 101
MET A 199
THR A 134
TYR A 163
 None
 1.41A 1uw6P-5ucoA:
undetectable
1uw6T-5ucoA:
undetectable		 1uw6P-5ucoA:
17.61
1uw6T-5ucoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 7 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.04A 1yrdA-5ucoA:
undetectable		 1yrdA-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		3 / 3 ASN A 183
ASN A 184
ARG A 158
 None
 0.81A 2rlcA-5ucoA:
undetectable		 2rlcA-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 SER A 136
GLY A 170
ILE A 375
THR A 172
PHE A 279
 None
 1.46A 3a25A-5ucoA:
undetectable		 3a25A-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 ILE A 283
VAL A 317
ILE A 313
LEU A 278
VAL A 383
 None
 0.99A 3fpjB-5ucoA:
undetectable		 3fpjB-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 6 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.03A 4ek1A-5ucoA:
undetectable		 4ek1A-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 6 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.03A 4g3rA-5ucoA:
undetectable		 4g3rA-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 ASN A 340
ARG A  71
LEU A 335
ILE A 314
 None
 1.00A 4k0bA-5ucoA:
undetectable		 4k0bA-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 6 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.03A 4kkyX-5ucoA:
undetectable		 4kkyX-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 6 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.08A 4l4cA-5ucoA:
undetectable		 4l4cA-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 PHE A  42
GLU A  77
THR A  47
PHE A 201
GLY A  85
 None
 1.38A 4q15A-5ucoA:
undetectable		 4q15A-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 7 PHE A 291
LEU A 294
SER A 301
VAL A 387
 None
 1.05A 4wnvD-5ucoA:
undetectable		 4wnvD-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 6 LEU A 353
LEU A 388
PHE A 303
ILE A 306
 None
 1.19A 4y4dA-5ucoA:
undetectable		 4y4dA-5ucoA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 ILE A 313
VAL A 383
ALA A 385
VAL A 286
GLY A 372
 None
 1.25A 5igiA-5ucoA:
undetectable		 5igiA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 ILE A 313
VAL A 383
MET A 287
VAL A 286
GLY A 372
 None
 1.10A 5igiA-5ucoA:
undetectable		 5igiA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 ILE A 313
VAL A 383
MET A 287
VAL A 286
GLY A 372
 None
 1.08A 5igjA-5ucoA:
undetectable		 5igjA-5ucoA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 GLU A  82
ALA A  96
THR A 200
GLN A 215
LEU A  75
 None
 1.39A 5m54B-5ucoA:
undetectable		 5m54B-5ucoA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 7 TYR A 304
LEU A 321
VAL A 317
VAL A 383
 None
 1.04A 5wk9A-5ucoA:
undetectable		 5wk9A-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 12 ILE A 250
THR A 249
GLN A 248
THR A 172
VAL A 176
 None
 1.06A 6bzoC-5ucoA:
undetectable		 6bzoC-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		4 / 8 ILE A 250
THR A 249
THR A 172
ARG A 175
 None
 0.94A 6c06C-5ucoA:
undetectable		 6c06C-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE
(Hypericum
androsaemum) 		5 / 11 PHE A  73
LEU A  75
THR A  76
ILE A  34
PHE A 201
 None
 1.00A 6gp2A-5ucoA:
undetectable		 6gp2A-5ucoA:
23.53