SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ucr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PG2_A_ADNA552_1 (METHIONYL-TRNA SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 11	HIS A 30 GLY A 32 HIS A 33 GLY A 144 ASP A 147	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) ANP A 301 (-3.2A) ANP A 301 (-3.7A)	0.88A	1pg2A-5ucrA: 3.7	1pg2A-5ucrA: 20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNA SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 12	HIS A 30 GLY A 32 HIS A 33 GLY A 144 ASP A 147	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) ANP A 301 (-3.2A) ANP A 301 (-3.7A)	0.93A	1qu2A-5ucrA: 2.7	1qu2A-5ucrA: 15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VE3_A_REAA1445_1 (PUTATIVE CYTOCHROME P450 120)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 12	THR A 25 ALA A 88 LEU A 71 ALA A 75 VAL A 83	ANP A 301 ( 4.6A) None None None None	0.98A	2ve3A-5ucrA: undetectable	2ve3A-5ucrA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_A_ADNA601_1 (METHIONYL-TRNA SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 11	HIS A 30 GLY A 32 HIS A 33 GLY A 144 ASP A 147	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) ANP A 301 (-3.2A) ANP A 301 (-3.7A)	0.87A	2x1lA-5ucrA: 2.7	2x1lA-5ucrA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_B_ADNB601_1 (METHIONYL-TRNA SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 12	HIS A 30 GLY A 32 HIS A 33 GLY A 144 ASP A 147	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) ANP A 301 (-3.2A) ANP A 301 (-3.7A)	0.82A	2x1lB-5ucrA: undetectable	2x1lB-5ucrA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X1L_C_ADNC601_1 (METHIONYL-TRNA SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 11	HIS A 30 GLY A 32 HIS A 33 GLY A 144 ASP A 147	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) ANP A 301 (-3.2A) ANP A 301 (-3.7A)	0.85A	2x1lC-5ucrA: 5.5	2x1lC-5ucrA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	3 / 3	ARG A 41 ASP A 139 ASN A 46	None	0.86A	2zzmA-5ucrA: 2.4	2zzmA-5ucrA: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NVC_A_SALA370_1 (GENTISATE 1,2-DIOXYGENASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	4 / 6	GLN A 150 HIS A 33 HIS A 30 ASP A 147	ALA A 302 (-3.9A) ANP A 301 (-4.1A) ANP A 301 (-4.4A) ANP A 301 (-3.7A)	1.09A	3nvcA-5ucrA: undetectable	3nvcA-5ucrA: 24.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3UY4_A_PAUA302_0 (PANTOTHENATE SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	7 / 8	ARG A 118 HIS A 121 VAL A 125 VAL A 128 ASP A 147 GLN A 150 ARG A 184	None None ALA A 302 ( 4.6A) None ANP A 301 (-3.7A) ALA A 302 (-3.9A) ANP A 301 (-3.4A)	0.74A	3uy4A-5ucrA: 36.0	3uy4A-5ucrA: 40.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CR1_A_T44A201_1 (TRANSTHYRETIN)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	4 / 5	LEU A 264 ALA A 262 LEU A 269 VAL A 238	None	1.07A	5cr1A-5ucrA: undetectable	5cr1A-5ucrA: 16.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	9 / 12	HIS A 30 GLY A 32 LEU A 36 VAL A 128 GLY A 144 LYS A 146 ASP A 147 THR A 172 LEU A 181	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.5A) None ANP A 301 (-3.2A) ANP A 301 (-2.8A) ANP A 301 (-3.7A) ANP A 301 (-4.1A) ANP A 301 (-4.5A)	0.48A	5hg0A-5ucrA: 30.7	5hg0A-5ucrA: 35.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	6 / 12	HIS A 30 GLY A 32 VAL A 129 LYS A 146 ASP A 147 LEU A 181	ANP A 301 (-4.4A) ANP A 301 (-3.6A) None ANP A 301 (-2.8A) ANP A 301 (-3.7A) ANP A 301 (-4.5A)	1.15A	5hg0A-5ucrA: 30.7	5hg0A-5ucrA: 35.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	10 / 12	HIS A 30 GLY A 32 HIS A 33 LEU A 36 VAL A 128 GLY A 144 LYS A 146 ASP A 147 THR A 172 LEU A 181	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) ANP A 301 (-4.5A) None ANP A 301 (-3.2A) ANP A 301 (-2.8A) ANP A 301 (-3.7A) ANP A 301 (-4.1A) ANP A 301 (-4.5A)	0.38A	5hg0B-5ucrA: 30.7	5hg0B-5ucrA: 35.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	7 / 12	HIS A 30 GLY A 32 HIS A 33 VAL A 129 LYS A 146 ASP A 147 LEU A 181	ANP A 301 (-4.4A) ANP A 301 (-3.6A) ANP A 301 (-4.1A) None ANP A 301 (-2.8A) ANP A 301 (-3.7A) ANP A 301 (-4.5A)	1.13A	5hg0B-5ucrA: 30.7	5hg0B-5ucrA: 35.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5HG0_B_SAMB301_0 (PANTOTHENATE SYNTHETASE)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	6 / 12	HIS A 33 GLY A 32 GLY A 144 LYS A 146 ASP A 147 THR A 172	ANP A 301 (-4.1A) ANP A 301 (-3.6A) ANP A 301 (-3.2A) ANP A 301 (-2.8A) ANP A 301 (-3.7A) ANP A 301 (-4.1A)	1.24A	5hg0B-5ucrA: 30.7	5hg0B-5ucrA: 35.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWC_A_FK5A201_1 (FK506-BINDING PROTEIN 1A)	5ucr	PANTOTHENATE SYNTHETASE (Neisseria gonorrhoeae)	5 / 11	ARG A 11 VAL A 128 PHE A 163 ILE A 165 PHE A 22	None	1.29A	5hwcA-5ucrA: undetectable	5hwcA-5ucrA: 18.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1PG2_A_ADNA552_1","METHIONYL-TRNA SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"HIS A  30;GLY A  32;HIS A  33;GLY A 144;ASP A 147","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);ANP A 301 (-3.2A);ANP A 301 (-3.7A)","0.88A","1pg2A-5ucrA:3.7","1pg2A-5ucrA:20.26"],["1QU2_A_MRCA1993_1","ISOLEUCYL-TRNA SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"HIS A  30;GLY A  32;HIS A  33;GLY A 144;ASP A 147","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);ANP A 301 (-3.2A);ANP A 301 (-3.7A)","0.93A","1qu2A-5ucrA:2.7","1qu2A-5ucrA:15.18"],["2VE3_A_REAA1445_1","PUTATIVE CYTOCHROME P450 120","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"THR A  25;ALA A  88;LEU A  71;ALA A  75;VAL A  83","ANP A 301 ( 4.6A);None;None;None;None","0.98A","2ve3A-5ucrA:undetectable","2ve3A-5ucrA:21.71"],["2X1L_A_ADNA601_1","METHIONYL-TRNA SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"HIS A  30;GLY A  32;HIS A  33;GLY A 144;ASP A 147","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);ANP A 301 (-3.2A);ANP A 301 (-3.7A)","0.87A","2x1lA-5ucrA:2.7","2x1lA-5ucrA:21.43"],["2X1L_B_ADNB601_1","METHIONYL-TRNA SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"HIS A  30;GLY A  32;HIS A  33;GLY A 144;ASP A 147","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);ANP A 301 (-3.2A);ANP A 301 (-3.7A)","0.82A","2x1lB-5ucrA:undetectable","2x1lB-5ucrA:21.43"],["2X1L_C_ADNC601_1","METHIONYL-TRNA SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"HIS A  30;GLY A  32;HIS A  33;GLY A 144;ASP A 147","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);ANP A 301 (-3.2A);ANP A 301 (-3.7A)","0.85A","2x1lC-5ucrA:5.5","2x1lC-5ucrA:21.43"],["2ZZM_A_SAMA401_1","UNCHARACTERIZED PROTEIN MJ0883","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",3,"ARG A  41;ASP A 139;ASN A  46","None","0.86A","2zzmA-5ucrA:2.4","2zzmA-5ucrA:21.97"],["3NVC_A_SALA370_1","GENTISATE 1,2-DIOXYGENASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",4,"GLN A 150;HIS A  33;HIS A  30;ASP A 147","ALA A 302 (-3.9A);ANP A 301 (-4.1A);ANP A 301 (-4.4A);ANP A 301 (-3.7A)","1.09A","3nvcA-5ucrA:undetectable","3nvcA-5ucrA:24.27"],["3UY4_A_PAUA302_0","PANTOTHENATE SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",7,"ARG A 118;HIS A 121;VAL A 125;VAL A 128;ASP A 147;GLN A 150;ARG A 184","None;None;ALA A 302 ( 4.6A);None;ANP A 301 (-3.7A);ALA A 302 (-3.9A);ANP A 301 (-3.4A)","0.74A","3uy4A-5ucrA:36.0","3uy4A-5ucrA:40.41"],["5CR1_A_T44A201_1","TRANSTHYRETIN","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",4,"LEU A 264;ALA A 262;LEU A 269;VAL A 238","None","1.07A","5cr1A-5ucrA:undetectable","5cr1A-5ucrA:16.84"],["5HG0_A_SAMA301_0","PANTOTHENATE SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",9,"HIS A  30;GLY A  32;LEU A  36;VAL A 128;GLY A 144;LYS A 146;ASP A 147;THR A 172;LEU A 181","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.5A);None;ANP A 301 (-3.2A);ANP A 301 (-2.8A);ANP A 301 (-3.7A);ANP A 301 (-4.1A);ANP A 301 (-4.5A)","0.48A","5hg0A-5ucrA:30.7","5hg0A-5ucrA:35.93"],["5HG0_A_SAMA301_0","PANTOTHENATE SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",6,"HIS A  30;GLY A  32;VAL A 129;LYS A 146;ASP A 147;LEU A 181","ANP A 301 (-4.4A);ANP A 301 (-3.6A);None;ANP A 301 (-2.8A);ANP A 301 (-3.7A);ANP A 301 (-4.5A)","1.15A","5hg0A-5ucrA:30.7","5hg0A-5ucrA:35.93"],["5HG0_B_SAMB301_0","PANTOTHENATE SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",10,"HIS A  30;GLY A  32;HIS A  33;LEU A  36;VAL A 128;GLY A 144;LYS A 146;ASP A 147;THR A 172;LEU A 181","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);ANP A 301 (-4.5A);None;ANP A 301 (-3.2A);ANP A 301 (-2.8A);ANP A 301 (-3.7A);ANP A 301 (-4.1A);ANP A 301 (-4.5A)","0.38A","5hg0B-5ucrA:30.7","5hg0B-5ucrA:35.93"],["5HG0_B_SAMB301_0","PANTOTHENATE SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",7,"HIS A  30;GLY A  32;HIS A  33;VAL A 129;LYS A 146;ASP A 147;LEU A 181","ANP A 301 (-4.4A);ANP A 301 (-3.6A);ANP A 301 (-4.1A);None;ANP A 301 (-2.8A);ANP A 301 (-3.7A);ANP A 301 (-4.5A)","1.13A","5hg0B-5ucrA:30.7","5hg0B-5ucrA:35.93"],["5HG0_B_SAMB301_0","PANTOTHENATE SYNTHETASE","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",6,"HIS A  33;GLY A  32;GLY A 144;LYS A 146;ASP A 147;THR A 172","ANP A 301 (-4.1A);ANP A 301 (-3.6A);ANP A 301 (-3.2A);ANP A 301 (-2.8A);ANP A 301 (-3.7A);ANP A 301 (-4.1A)","1.24A","5hg0B-5ucrA:30.7","5hg0B-5ucrA:35.93"],["5HWC_A_FK5A201_1","FK506-BINDING PROTEIN 1A","5ucr","PANTOTHENATE SYNTHETASE","Neisseria gonorrhoeae",5,"ARG A  11;VAL A 128;PHE A 163;ILE A 165;PHE A  22","None","1.29A","5hwcA-5ucrA:undetectable","5hwcA-5ucrA:18.09"]]