SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ucy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 4 THR A 179
GLY A  10
ASP A  69
ALA A  99
 GTP  A 501 (-3.6A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 2.1A)
GTP  A 501 (-2.9A)
 1.11A 1sg9A-5ucyA:
undetectable		 1sg9A-5ucyA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 5 PRO A 325
VAL A 328
ASN A 329
ILE A 355
 None
 0.92A 1z2bC-5ucyA:
51.9		 1z2bC-5ucyA:
86.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 5 PRO A 325
VAL A 328
ASN A 329
VAL A 353
 None
 1.01A 1z2bC-5ucyA:
51.9		 1z2bC-5ucyA:
86.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		3 / 3 GLY A 143
GLY A  13
GLY A  10
 GTP  A 501 (-1.5A)
None
GTP  A 501 (-2.2A)
 0.37A 3bogD-5ucyA:
undetectable		 3bogD-5ucyA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		3 / 3 CYH A  25
HIS A  28
PHE A  24
 None
 1.02A 3cr4X-5ucyA:
undetectable		 3cr4X-5ucyA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.79A 3e9rA-5ucyA:
undetectable		 3e9rA-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.78A 3e9rC-5ucyA:
undetectable		 3e9rC-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 224
GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-1.0A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.95A 3f8wA-5ucyA:
undetectable		 3f8wA-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 224
GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-1.0A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.97A 3f8wB-5ucyA:
undetectable		 3f8wB-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 224
GLY A 144
GLU A  71
GLY A  10
ASN A 101
 GTP  A 501 (-1.0A)
GTP  A 501 (-2.2A)
GTP  A 501 ( 1.8A)
GTP  A 501 (-2.2A)
GTP  A 501 (-3.3A)
 0.95A 3f8wC-5ucyA:
undetectable		 3f8wC-5ucyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 ILE A 188
ASN A 186
PRO A 173
LEU A 391
 None
 1.16A 3oi8A-5ucyA:
undetectable		 3oi8A-5ucyA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 TYR A 272
ILE A 275
SER A 236
SER A 237
 None
 1.00A 3pmzD-5ucyA:
undetectable		 3pmzD-5ucyA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 PRO A 325
ASN A 329
ILE A 332
VAL A 353
ILE A 355
 None
 0.86A 4eb6B-5ucyA:
47.3
4eb6C-5ucyA:
52.2		 4eb6B-5ucyA:
40.96
4eb6C-5ucyA:
85.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 7 PHE A 351
ASN A 329
ALA A 333
THR A 337
 None
 1.07A 4ejgA-5ucyA:
undetectable		 4ejgA-5ucyA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 VAL A 375
ALA A 374
TYR A 319
PHE A 296
THR A 292
 None
 1.32A 4mm6A-5ucyA:
undetectable		 4mm6A-5ucyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		4 / 6 LEU A 259
ASN A 380
MET A 318
ILE A 384
 None
 1.10A 4okxA-5ucyA:
undetectable		 4okxA-5ucyA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 VAL A  74
GLY A  13
ILE A  75
GLY A  17
ILE A   7
 None
 0.88A 4q5mA-5ucyA:
undetectable		 4q5mA-5ucyA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 9 LEU A 149
GLY A 111
ILE A  93
LEU A 117
VAL A 115
 None
 1.15A 4x3mB-5ucyA:
undetectable		 4x3mB-5ucyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 11 GLY A  17
ILE A 171
MET A 203
LEU A 204
ILE A 235
 None
 1.01A 4xumB-5ucyA:
undetectable		 4xumB-5ucyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 11 PHE A 138
ILE A   7
LEU A 119
LEU A 154
GLY A 150
 None
 1.20A 5fctA-5ucyA:
undetectable		 5fctA-5ucyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 TYR A 272
LEU A  23
SER A 236
ILE A 235
HIS A   8
 None
 1.32A 5h1eA-5ucyA:
undetectable		 5h1eA-5ucyA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 GLU A  27
LEU A 217
LEU A 230
SER A 236
PRO A 360
 None
 0.95A 5hnwB-5ucyA:
49.9		 5hnwB-5ucyA:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 GLU A  27
LEU A 217
LEU A 230
SER A 236
PRO A 360
 None
 0.96A 5hnyB-5ucyA:
49.8		 5hnyB-5ucyA:
41.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		6 / 12 LEU A 248
VAL A 328
ASN A 329
ILE A 332
ALA A 333
GLY A 354
 None
 1.40A 5j2tC-5ucyA:
53.3		 5j2tC-5ucyA:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		6 / 12 LEU A 248
VAL A 328
ILE A 332
ALA A 333
GLY A 354
ILE A 355
 None
 1.29A 5j2tC-5ucyA:
53.3		 5j2tC-5ucyA:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		9 / 12 PRO A 325
VAL A 328
ASN A 329
ILE A 332
ALA A 333
LYS A 336
PHE A 351
VAL A 353
GLY A 354
 None
 0.94A 5j2tC-5ucyA:
53.3		 5j2tC-5ucyA:
85.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		9 / 12 PRO A 325
VAL A 328
ILE A 332
ALA A 333
LYS A 336
PHE A 351
VAL A 353
GLY A 354
ILE A 355
 None
 0.96A 5j2tC-5ucyA:
53.3		 5j2tC-5ucyA:
85.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 ILE A  30
PRO A  63
LEU A  86
GLU A  55
ASN A  50
 None
 1.24A 5k7uA-5ucyA:
undetectable		 5k7uA-5ucyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 7 ALA A  48
ASP A  47
ASP A  46
GLY A  43
ILE A  42
 None
 1.44A 5kqyB-5ucyA:
undetectable		 5kqyB-5ucyA:
11.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 GLU A  27
LEU A 217
LEU A 230
SER A 236
ARG A 320
 None
 0.86A 5nd7B-5ucyA:
50.2		 5nd7B-5ucyA:
41.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 GLY A 148
PHE A 103
LEU A 194
GLY A 168
GLY A 142
 None
None
None
None
GTP  A 501 (-2.8A)
 1.31A 5tuiB-5ucyA:
undetectable		 5tuiB-5ucyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 ALA A 273
ASN A 216
ASN A 300
SER A 294
ASN A 293
 None
 0.94A 6c79A-5ucyA:
undetectable		 6c79A-5ucyA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 THR A 191
TYR A 185
ALA A 400
LEU A 425
ASP A 396
 None
 1.06A 6ie8A-5ucyA:
undetectable		 6ie8A-5ucyA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 PHE A 138
ILE A   7
LEU A 119
LEU A 154
GLY A 150
 None
 1.13A 6r2eA-5ucyA:
undetectable		 6r2eA-5ucyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 10 PHE A 138
ILE A   7
LEU A 119
LEU A 154
GLY A 150
 None
 1.16A 6r2eD-5ucyA:
undetectable		 6r2eD-5ucyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 12 PHE A 138
ILE A   7
LEU A 119
LEU A 154
GLY A 150
 None
 1.19A 6r2eE-5ucyA:
undetectable		 6r2eE-5ucyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5ucy TUBULIN ALPHA CHAIN
(Tetrahymena
thermophila) 		5 / 11 PHE A 138
ILE A   7
LEU A 119
LEU A 154
GLY A 150
 None
 1.17A 6r2eG-5ucyA:
undetectable		 6r2eG-5ucyA:
20.67