SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5udb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 VAL 8 130
VAL 8 134
TRP 8 239
 None
 0.93A 1av2A-5udb8:
undetectable
1av2B-5udb8:
undetectable		 1av2A-5udb8:
3.26
1av2B-5udb8:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 ILE 2 606
ALA 2 648
ALA 2 650
PRO 2 652
TYR 2 657
 None
 1.02A 1cbsA-5udb2:
undetectable		 1cbsA-5udb2:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 12 ILE 6 638
ALA 6 680
PRO 6 684
LEU 6 695
TYR 6 689
 None
 1.01A 1cbsA-5udb6:
undetectable		 1cbsA-5udb6:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 10 GLY 3 436
ARG 3 291
LEU 3 428
GLU 3 263
PRO 3 262
 None
 1.26A 1cmcA-5udb3:
undetectable
1cmcB-5udb3:
undetectable		 1cmcA-5udb3:
7.81
1cmcB-5udb3:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 ILE 6 563
MET 2 501
VAL 2 603
GLY 6 562
 None
 0.98A 1e06B-5udb6:
undetectable		 1e06B-5udb6:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 11 LEU 6 119
GLU 6 113
ARG 6 187
ILE 6 265
LEU 6 158
 None
 1.28A 1g50C-5udb6:
undetectable		 1g50C-5udb6:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 9 ASP 9 487
THR 9 463
ILE 9 464
THR 9 420
ILE 9 417
 None
 1.27A 1hzeA-5udb9:
undetectable
1hzeB-5udb9:
undetectable		 1hzeA-5udb9:
11.11
1hzeB-5udb9:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 9 THR 9 420
ILE 9 417
ASP 9 487
THR 9 463
ILE 9 464
 None
 1.27A 1hzeA-5udb9:
undetectable
1hzeB-5udb9:
undetectable		 1hzeA-5udb9:
11.11
1hzeB-5udb9:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 10 ASP 9 487
THR 9 463
ILE 9 464
THR 9 420
ILE 9 417
 None
 1.34A 1i18A-5udb9:
undetectable
1i18B-5udb9:
undetectable		 1i18A-5udb9:
11.11
1i18B-5udb9:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		5 / 10 THR 9 420
ILE 9 417
ASP 9 487
THR 9 463
ILE 9 464
 None
 1.32A 1i18A-5udb9:
undetectable
1i18B-5udb9:
undetectable		 1i18A-5udb9:
11.11
1i18B-5udb9:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 ILE 6 368
ARG 6 277
ASP 8 544
ASN 8 547
 None
 1.48A 1kiaD-5udb6:
2.0		 1kiaD-5udb6:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 11 ARG 3 291
LEU 3 428
GLU 3 263
PRO 3 262
GLY 3 436
 None
 1.29A 1mjqA-5udb3:
0.7
1mjqB-5udb3:
0.5		 1mjqA-5udb3:
7.81
1mjqB-5udb3:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 11 THR 3 432
VAL 3 440
GLY 3 441
VAL 3 512
VAL 3 470
 None
 1.17A 1phgA-5udb3:
undetectable		 1phgA-5udb3:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 4 ALA 2 563
VAL 2 556
ALA 2 560
HIS 2 561
 None
 1.18A 1q23F-5udb2:
undetectable		 1q23F-5udb2:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 4 ALA 2 563
VAL 2 556
ALA 2 560
HIS 2 561
 None
 1.19A 1q23K-5udb2:
undetectable		 1q23K-5udb2:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 GLY 3 468
MET 3 462
VAL 3 489
MET 3 490
THR 3 432
 None
 1.47A 1z95A-5udb3:
undetectable		 1z95A-5udb3:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 12 MET 5 497
PHE 5 550
PHE 5 554
ALA 5 521
ILE 5 384
 None
 1.26A 2bjfA-5udb5:
undetectable		 2bjfA-5udb5:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		3 / 3 LYS 5 422
ASP 5 531
ASN 5 524
 None
 0.99A 2bm9A-5udb5:
undetectable		 2bm9A-5udb5:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 LEU 2 268
GLU 2 292
ASN 2 454
ASP 2 272
ALA 2 278
 None
 1.23A 2br4B-5udb2:
undetectable		 2br4B-5udb2:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 LEU 2 268
GLU 2 292
ASP 2 272
ALA 2 275
ALA 2 278
 None
 1.27A 2br4B-5udb2:
undetectable		 2br4B-5udb2:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 5 LEU 2 268
LEU 2 242
SER 2 241
ARG 2 230
 None
 0.78A 2byoA-5udb2:
undetectable		 2byoA-5udb2:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 LEU 2 519
VAL 2 515
VAL 2 539
GLY 2 522
LEU 2 834
 None
 1.15A 2cbrA-5udb2:
undetectable		 2cbrA-5udb2:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 5 GLY 5 419
LYS 5 422
LEU 5 414
PRO 5 525
 None
 1.42A 2dqyA-5udb5:
undetectable		 2dqyA-5udb5:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 10 GLY 5 537
ILE 5 540
PHE 5 550
LEU 5 413
ILE 5 553
 None
 0.98A 2f8dA-5udb5:
undetectable		 2f8dA-5udb5:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 ILE 2 606
ALA 2 648
ALA 2 650
PRO 2 652
TYR 2 657
 None
 1.01A 2fr3A-5udb2:
undetectable		 2fr3A-5udb2:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 12 ILE 6 638
ALA 6 680
PRO 6 684
LEU 6 695
TYR 6 689
 None
 1.05A 2fr3A-5udb6:
undetectable		 2fr3A-5udb6:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 12 PHE 8 318
LEU 8 363
VAL 8 404
ALA 8 310
PHE 8 313
 None
 1.31A 2g70B-5udb8:
undetectable		 2g70B-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 12 PHE 8 318
LEU 8 363
VAL 8 404
ALA 8 310
PHE 8 313
 None
 1.31A 2g72A-5udb8:
undetectable		 2g72A-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 7 LEU 8  58
ILE 8 114
ARG 8 117
TYR 8  92
 None
 1.04A 2hc4A-5udb8:
undetectable		 2hc4A-5udb8:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 11 GLY 5 416
ASN 5 381
THR 5 420
GLY 5 419
PHE 5 379
 None
 1.13A 2hmaA-5udb5:
undetectable		 2hmaA-5udb5:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 6 LEU 9 334
ILE 9 317
VAL 9 300
ALA 9 321
 None
 0.85A 2j5mA-5udb9:
undetectable		 2j5mA-5udb9:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		3 / 3 ARG 2 854
ARG 2 858
ARG 2 855
 None
 0.86A 2jb7A-5udb2:
undetectable
2jb7B-5udb2:
undetectable
2jb7C-5udb2:
undetectable		 2jb7A-5udb2:
11.38
2jb7B-5udb2:
11.38
2jb7C-5udb2:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		3 / 3 ARG 2 855
ARG 2 854
ARG 2 858
 None
 0.86A 2jb7A-5udb2:
undetectable
2jb7B-5udb2:
undetectable
2jb7C-5udb2:
undetectable		 2jb7A-5udb2:
11.38
2jb7B-5udb2:
11.38
2jb7C-5udb2:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		3 / 3 ARG 2 858
ARG 2 855
ARG 2 854
 None
 0.90A 2jb7A-5udb2:
undetectable
2jb7B-5udb2:
undetectable
2jb7C-5udb2:
undetectable		 2jb7A-5udb2:
11.38
2jb7B-5udb2:
11.38
2jb7C-5udb2:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 MET 3 462
VAL 3 489
MET 3 490
MET 3 478
THR 3 432
 None
 1.46A 2q7iA-5udb3:
undetectable		 2q7iA-5udb3:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 MET 3 462
VAL 3 489
MET 3 490
MET 3 478
THR 3 432
 None
 1.45A 2q7lA-5udb3:
undetectable		 2q7lA-5udb3:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 8 PRO 5  83
SER 5  84
VAL 5 160
GLY 5 296
 None
 1.12A 2qd3A-5udb5:
undetectable		 2qd3A-5udb5:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 ARG 6 798
PHE 6 709
ILE 6 678
PHE 6 641
 AGS  22001 (-3.6A)
None
None
None
 1.10A 2qeiA-5udb6:
undetectable		 2qeiA-5udb6:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 10 GLU 6 801
ILE 6 804
ARG 6 805
HIS 2 703
ASP 6 710
 None
 1.49A 2qeoB-5udb6:
undetectable		 2qeoB-5udb6:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 SER 8 146
TYR 8 148
HIS 8 147
 None
 0.78A 2r2vD-5udb8:
1.6		 2r2vD-5udb8:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 11 SER 5 624
THR 5 660
ARG 3 567
GLU 3 563
LEU 5 614
 None
 1.28A 2v0mD-5udb5:
undetectable		 2v0mD-5udb5:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		5 / 10 ILE D 146
PHE D 181
MET D 237
VAL D 243
LEU D 185
 None
 1.43A 2w98A-5udbD:
undetectable		 2w98A-5udbD:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 7 ILE 6 661
LEU 6 672
GLY 6 392
GLY 6 626
 None
 0.62A 2wd9A-5udb6:
undetectable		 2wd9A-5udb6:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 8 ILE 6 661
LEU 6 672
GLY 6 392
GLY 6 626
 None
 0.63A 2wd9B-5udb6:
undetectable		 2wd9B-5udb6:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 12 ILE 5 399
MET 5 552
PHE 5 554
ALA 5 686
LEU 5 663
 None
 1.23A 2x2nD-5udb5:
undetectable		 2x2nD-5udb5:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 4 ARG 6 161
GLY 6 164
GLU 6 162
SER 8 592
 None
 1.38A 2xctS-5udb6:
undetectable
2xctU-5udb6:
undetectable		 2xctS-5udb6:
23.21
2xctU-5udb6:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 LEU 2 793
SER 2 860
HIS 2 809
PRO 2 804
GLN 2 856
 None
 1.49A 2xpwA-5udb2:
1.7		 2xpwA-5udb2:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 GLU 5 637
ARG 5 630
ASP 3 551
ASP 3 524
 None
 1.29A 2yqzA-5udb5:
undetectable		 2yqzA-5udb5:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 GLU 5 637
ARG 5 630
ASP 3 551
ASP 3 524
 None
 1.29A 2yqzB-5udb5:
undetectable		 2yqzB-5udb5:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 4 LEU 9 416
GLN 9 423
THR 9 420
THR 9 449
 None
 1.47A 2zj0D-5udb9:
undetectable		 2zj0D-5udb9:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		3 / 3 THR 6 295
PRO 6 391
THR 6 297
 None
 0.69A 316dC-5udb6:
undetectable		 316dC-5udb6:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 11 ILE 5 540
PHE 5 550
SER 5 548
PHE 5 482
LEU 5 449
 None
 1.22A 3a9eB-5udb5:
undetectable		 3a9eB-5udb5:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 8 VAL 6 573
LEU 6 830
LYS 6 545
GLY 6 546
 None
 0.91A 3af0A-5udb6:
undetectable		 3af0A-5udb6:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 ARG 2 836
ILE 2 494
ILE 2 755
SER 2 756
ALA 2 502
 None
 1.09A 3axtA-5udb2:
undetectable		 3axtA-5udb2:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 10 TYR 8  48
ASP 8  19
ASN 8  21
LEU 8  45
PHE 8  43
 None
 1.33A 3ay0A-5udb8:
undetectable		 3ay0A-5udb8:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 8 GLU 5 637
SER 5 645
GLN 3 522
VAL 3 549
 None
 1.12A 3b9lA-5udb5:
2.4		 3b9lA-5udb5:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 11 PRO 2 264
LYS 2 431
VAL 2 318
GLY 2 322
GLU 2 392
 None
 1.33A 3bf6H-5udb2:
undetectable		 3bf6H-5udb2:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 7 VAL 6 589
ILE 6 547
GLY 6 546
LEU 6 806
 None
 0.78A 3bjwB-5udb6:
undetectable		 3bjwB-5udb6:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 7 VAL 6 589
ILE 6 547
GLY 6 546
LEU 6 806
 None
 0.75A 3bjwF-5udb6:
undetectable		 3bjwF-5udb6:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 7 VAL 6 589
ILE 6 547
GLY 6 546
LEU 6 806
 None
 0.75A 3bjwH-5udb6:
undetectable		 3bjwH-5udb6:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 8 SER 5 515
ALA 5 468
ILE 5 479
THR 5 439
 None
 0.96A 3bpxA-5udb5:
undetectable
3bpxB-5udb5:
undetectable		 3bpxA-5udb5:
11.96
3bpxB-5udb5:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		3 / 3 ALA 9 443
THR 9 447
CYH 9 419
 None
 0.75A 3e4eA-5udb9:
undetectable		 3e4eA-5udb9:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		3 / 3 ALA 9 443
THR 9 447
CYH 9 419
 None
 0.68A 3e4eB-5udb9:
undetectable		 3e4eB-5udb9:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		3 / 3 ASN D 409
MET D 496
PHE D 499
 None
 1.14A 3g4lD-5udbD:
undetectable		 3g4lD-5udbD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASN 8 157
MET 2 783
PHE 2 828
 None
 1.10A 3g4lD-5udb8:
undetectable		 3g4lD-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 4 PHE 8 119
LYS 8 120
ILE 8 143
THR 8 150
 None
 1.35A 3ia4B-5udb8:
undetectable		 3ia4B-5udb8:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		3 / 3 ASN 2 384
ASP 2 413
ARG 2 288
 None
 0.78A 3k13C-5udb2:
undetectable		 3k13C-5udb2:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 GLY 2 521
SER 2 645
ARG 2 643
ALA 2 599
ASP 2 600
 None
 1.06A 3keeA-5udb2:
undetectable		 3keeA-5udb2:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 GLY 3 387
VAL 3 463
GLY 3 468
SER 3 511
ARG 3 400
 None
 1.05A 3keeC-5udb3:
undetectable		 3keeC-5udb3:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 GLY 2 521
SER 2 645
ARG 2 643
ALA 2 599
ASP 2 600
 None
 1.01A 3keeD-5udb2:
undetectable		 3keeD-5udb2:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 5 ILE D 247
PHE D 235
ASP D 236
GLU D 239
 None
 1.16A 3kp6A-5udbD:
undetectable
3kp6B-5udbD:
4.9		 3kp6A-5udbD:
15.69
3kp6B-5udbD:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		3 / 3 ARG 2 326
ASP 2 435
GLN 2 333
 None
 0.90A 3lcvB-5udb2:
undetectable		 3lcvB-5udb2:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 5 LEU 2 680
ARG 2 676
ILE 2 646
PHE 2 677
 None
 1.29A 3ln1D-5udb2:
undetectable		 3ln1D-5udb2:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 8 TYR 9 105
PRO 9 109
ASP 9 266
LYS 9 268
 None
AGS  92001 (-4.5A)
None
None
 0.91A 3lsfH-5udb9:
undetectable		 3lsfH-5udb9:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 SER 6 791
ASP 2 544
ASN 2 651
 None
None
AGS  22001 (-3.0A)
 0.77A 3lslA-5udb6:
undetectable
3lslD-5udb6:
undetectable		 3lslA-5udb6:
14.63
3lslD-5udb6:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 LEU 3 385
GLY 3 387
GLY 3 388
ILE 3 381
ASN 3 404
 None
 1.09A 3nk7A-5udb3:
undetectable		 3nk7A-5udb3:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 ILE 3 381
HIS 3 374
ALA 3 368
LEU 3 367
ILE 3 561
 None
 1.14A 3ozwB-5udb3:
undetectable		 3ozwB-5udb3:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 GLU 6 721
LYS 6 722
ASP 6 724
ASP 6 718
 None
 1.44A 3pocB-5udb6:
undetectable		 3pocB-5udb6:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU 2 251
GLY 2 223
THR 2 222
SER 8 210
THR 8 211
 None
 1.36A 3r75A-5udb2:
undetectable		 3r75A-5udb2:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLU 2 251
GLY 2 223
THR 2 222
SER 8 210
THR 8 211
 None
 1.36A 3r75B-5udb2:
undetectable		 3r75B-5udb2:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 12 ILE 5 504
LEU 5 513
ALA 5 447
VAL 5 437
VAL 5 470
 None
 1.02A 3rukA-5udb5:
undetectable		 3rukA-5udb5:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 7 TYR 6 906
ASN 6 914
GLN 6 833
TYR 6 828
 None
 1.18A 3ugrA-5udb6:
undetectable		 3ugrA-5udb6:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 7 GLU 5  91
THR 5  62
VAL 5  63
LEU 5 139
 None
 0.87A 3uniA-5udb5:
undetectable		 3uniA-5udb5:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 8 GLU 5  91
THR 5  62
VAL 5  63
LEU 5 139
 None
 0.86A 3uniB-5udb5:
undetectable		 3uniB-5udb5:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 12 ILE 5 555
ALA 5 523
LEU 5 413
LEU 5 547
ILE 5 540
 None
 1.08A 3uvvA-5udb5:
undetectable		 3uvvA-5udb5:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 5 ILE D  91
GLN D  88
ILE D  85
GLU D 115
 None
 1.21A 4a99D-5udbD:
undetectable		 4a99D-5udbD:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 5 ILE 2 552
ALA 2 502
HIS 2 508
ARG 2 509
 None
 1.12A 4ac9B-5udb2:
undetectable
4ac9C-5udb2:
undetectable		 4ac9B-5udb2:
20.41
4ac9C-5udb2:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 5 ILE 2 552
ALA 2 502
HIS 2 508
ARG 2 509
 None
 1.10A 4acaB-5udb2:
undetectable
4acaC-5udb2:
undetectable		 4acaB-5udb2:
20.41
4acaC-5udb2:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 SER 5 174
GLY 3 304
ALA 3 303
SER 5 248
PHE 3 298
 None
 1.41A 4bupB-5udb5:
4.0		 4bupB-5udb5:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 10 ARG 6 187
GLY 6 108
ALA 6 114
GLU 6 113
GLU 6 116
 None
 1.25A 4da7A-5udb6:
undetectable		 4da7A-5udb6:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5udb CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae) 		4 / 8 LEU 9 209
PHE 9 182
THR 9 241
PHE 9 256
 None
 0.94A 4drjB-5udb9:
undetectable		 4drjB-5udb9:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		3 / 3 GLY 3 159
SER 3 160
TRP 3 111
 None
 0.75A 4e7cD-5udb3:
undetectable		 4e7cD-5udb3:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 GLU 6 624
ILE 6 623
GLU 2 592
VAL 2 574
 None
 1.01A 4ejwB-5udb6:
undetectable		 4ejwB-5udb6:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		4 / 6 GLY 3 304
GLY 3 305
ASN 3 307
ILE 3 315
 None
 0.99A 4fglD-5udb3:
undetectable		 4fglD-5udb3:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		3 / 3 GLN 5  96
THR 5  95
THR 5  92
 None
 0.75A 4fu9A-5udb5:
undetectable		 4fu9A-5udb5:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		3 / 3 GLN 5  96
THR 5  95
THR 5  92
 None
 0.73A 4fufA-5udb5:
undetectable		 4fufA-5udb5:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		3 / 3 LYS 2 441
LEU 2 438
ALA 2 440
 None
 0.74A 4iizA-5udb2:
undetectable		 4iizA-5udb2:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		3 / 3 ARG 6 967
LYS 6 966
LYS 6 970
 None
 1.30A 4k50A-5udb6:
undetectable		 4k50A-5udb6:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		3 / 3 ARG 6 967
LYS 6 966
LYS 6 970
 None
 1.23A 4k50E-5udb6:
undetectable		 4k50E-5udb6:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		3 / 3 ARG 6 967
LYS 6 966
LYS 6 970
 None
 1.31A 4k50I-5udb6:
undetectable		 4k50I-5udb6:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		4 / 4 ILE 3  45
SER 3  41
ASP 3 281
ASP 3 279
 None
 1.38A 4krhB-5udb3:
undetectable		 4krhB-5udb3:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 12 LEU 6 185
VAL 6 189
ILE 6 140
GLN 6 139
ILE 6 151
 None
 1.01A 4ltwA-5udb6:
undetectable		 4ltwA-5udb6:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 7 GLU 6 512
GLU 6 515
GLU 6 749
GLU 8 553
 None
 1.16A 4mi4B-5udb6:
undetectable
4mi4C-5udb6:
undetectable		 4mi4B-5udb6:
11.59
4mi4C-5udb6:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 LEU 8 305
ILE 8 304
ARG 8 300
 None
 0.66A 4mk4B-5udb8:
undetectable		 4mk4B-5udb8:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 8 GLY D 102
GLU D 115
LEU D 111
LEU D 112
 None
 0.85A 4mwzB-5udbD:
undetectable		 4mwzB-5udbD:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 5 ALA 8 237
GLY 8 242
ASP 8 216
ASP 8  41
 None
 0.93A 4n48A-5udb8:
undetectable		 4n48A-5udb8:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 GLY 3 468
MET 3 462
VAL 3 489
MET 3 490
THR 3 432
 None
 1.49A 4ojbA-5udb3:
undetectable		 4ojbA-5udb3:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU 8 340
THR 8 382
LEU 8 325
VAL 8 372
 None
 1.03A 4qknA-5udb8:
8.8		 4qknA-5udb8:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 ARG 3 291
GLY 3 335
ALA 3 338
ALA 3 426
VAL 3 422
 None
 1.34A 4ryaA-5udb3:
undetectable		 4ryaA-5udb3:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 PHE 6 712
ASN 6 683
PRO 6 684
ARG 6 794
 None
AGS  61101 (-1.5A)
None
None
 1.41A 4yv5B-5udb6:
undetectable		 4yv5B-5udb6:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		4 / 6 PHE 6 712
ASN 6 683
PRO 6 684
ARG 6 794
 None
AGS  61101 (-1.5A)
None
None
 1.39A 4yv5A-5udb6:
undetectable		 4yv5A-5udb6:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		5 / 12 GLY 2 421
PHE 2 677
ILE 2 673
THR 2 567
LEU 2 576
 None
 1.05A 4ze2A-5udb2:
undetectable		 4ze2A-5udb2:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 6 ILE 2 494
PHE 2 820
ARG 2 836
ILE 2 498
 None
 1.14A 4zzcA-5udb2:
undetectable
4zzcB-5udb2:
undetectable		 4zzcA-5udb2:
16.09
4zzcB-5udb2:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
(Saccharomyces
cerevisiae) 		4 / 6 ILE 2 494
PHE 2 820
ARG 2 836
ILE 2 498
 None
 1.10A 4zzcB-5udb2:
undetectable
4zzcC-5udb2:
undetectable		 4zzcB-5udb2:
16.09
4zzcC-5udb2:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP 6 154
GLU 6 131
SER 8 522
 None
 0.65A 5bw4B-5udb6:
undetectable		 5bw4B-5udb6:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 9 THR 3 432
VAL 3 440
GLY 3 441
VAL 3 512
VAL 3 470
 None
 1.13A 5cp4A-5udb3:
undetectable		 5cp4A-5udb3:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 9 SER 5 170
GLN 5 454
GLU 5 461
ILE 5 509
ALA 5 507
 None
 1.41A 5entC-5udb5:
undetectable		 5entC-5udb5:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 12 PRO 5 612
GLY 5 394
ARG 5 607
ARG 5 613
LEU 5 614
 None
 1.04A 5h5fA-5udb5:
undetectable		 5h5fA-5udb5:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 8 GLN 8 543
ILE 8 557
THR 8 514
ASN 8 547
 None
 0.97A 5hwaA-5udb8:
undetectable		 5hwaA-5udb8:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 9 TYR 5 281
ILE 5 138
LEU 5 139
GLU 5  91
ILE 5  94
 None
 1.41A 5ifuB-5udb5:
undetectable		 5ifuB-5udb5:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 12 ALA 6 365
ALA 6 592
PHE 6 591
GLY 6 590
PRO 6 369
 None
 1.40A 5jglA-5udb6:
undetectable		 5jglA-5udb6:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Saccharomyces
cerevisiae) 		4 / 5 ILE D 184
LYS D 209
ILE D 210
VAL D 212
 None
 0.84A 5jmnA-5udbD:
undetectable		 5jmnA-5udbD:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		4 / 8 SER 5 174
ASP 5 252
PHE 3 298
SER 5 248
 None
 1.06A 5l1fA-5udb5:
undetectable
5l1fB-5udb5:
undetectable		 5l1fA-5udb5:
22.70
5l1fB-5udb5:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5
(Saccharomyces
cerevisiae) 		5 / 12 ASP 5 487
GLU 5 488
HIS 5 494
ALA 5 492
LEU 5 449
 None
 1.24A 5m54B-5udb5:
undetectable		 5m54B-5udb5:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		4 / 8 LEU 8  20
LEU 8 118
ASN 8  50
ILE 8 198
 None
 0.97A 5mzjA-5udb8:
undetectable		 5mzjA-5udb8:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ARG 2 656
GLY 2 546
PRO 2 545
THR 6 796
 None
AGS  22001 ( 4.4A)
AGS  22001 ( 4.4A)
None
 1.07A 5ny7A-5udb2:
undetectable		 5ny7A-5udb2:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 9 ILE 8 270
GLY 8 274
GLY 8 276
LEU 8 283
ALA 8 279
 None
 1.02A 5o96A-5udb8:
undetectable
5o96B-5udb8:
undetectable		 5o96A-5udb8:
16.67
5o96B-5udb8:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY 8 233
THR 8 234
GLY 8 194
LEU 8 128
PHE 8 125
 None
 1.11A 5ybbA-5udb8:
undetectable		 5ybbA-5udb8:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY 8 233
THR 8 234
PRO 8 192
LEU 8  45
PHE 8 125
 None
 1.13A 5ybbA-5udb8:
undetectable		 5ybbA-5udb8:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 GLY 3 460
PRO 3 288
GLY 3 289
LEU 3 442
ASP 3 482
 None
 1.21A 5yn6A-5udb3:
undetectable		 5yn6A-5udb3:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 GLY 3 460
PRO 3 288
GLY 3 289
LEU 3 442
ASP 3 482
 None
 1.20A 5yniA-5udb3:
undetectable		 5yniA-5udb3:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		5 / 12 GLY 3 460
PRO 3 288
GLY 3 289
LEU 3 442
ASP 3 482
 None
 1.22A 5ynmA-5udb3:
undetectable		 5ynmA-5udb3:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 ASP 8 369
PHE 8 318
ARG 8 399
 None
 1.03A 5yw0A-5udb8:
7.7		 5yw0A-5udb8:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5udb CELL DIVISION CYCLE
PROTEIN CDT1
(Saccharomyces
cerevisiae) 		3 / 3 ARG 8 117
ILE 8 114
SER 8 113
 None
 0.76A 5zw2A-5udb8:
undetectable		 5zw2A-5udb8:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM2
DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 LEU 2 553
LEU 2 605
ALA 2 566
THR 6 671
 None
 0.87A 6a7jA-5udb2:
undetectable		 6a7jA-5udb2:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 12 ALA 6 664
PHE 6 641
ALA 6 680
THR 6 676
LEU 6 628
 None
 1.31A 6aycA-5udb6:
2.6		 6aycA-5udb6:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		4 / 7 HIS 3 487
ARG 3 700
GLU 3 491
ARG 3 400
 None
AGS  32001 (-3.9A)
AGS  32001 (-2.0A)
None
 1.22A 6b8kA-5udb3:
undetectable		 6b8kA-5udb3:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		4 / 4 VAL 3 548
GLY 3 409
ASP 3 524
ASP 3 551
 None
 1.06A 6cjkC-5udb3:
undetectable		 6cjkC-5udb3:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 9 LEU 6 552
SER 6 677
GLY 6 634
ILE 6 635
ILE 6 569
 None
 1.10A 6ebpA-5udb6:
undetectable		 6ebpA-5udb6:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 10 LEU 6 552
SER 6 677
GLY 6 634
ILE 6 635
ILE 6 569
 None
 1.11A 6ebpB-5udb6:
undetectable		 6ebpB-5udb6:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM6
(Saccharomyces
cerevisiae) 		5 / 10 LEU 6 552
SER 6 677
GLY 6 634
ILE 6 635
ILE 6 569
 None
 1.13A 6ebpD-5udb6:
undetectable		 6ebpD-5udb6:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
CELL DIVISION
CONTROL PROTEIN 6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 PHE 9 319
ARG 3 847
ALA 9 391
 None
 0.88A 6ecfB-5udb9:
undetectable		 6ecfB-5udb9:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5udb DNA REPLICATION
LICENSING FACTOR
MCM3
(Saccharomyces
cerevisiae) 		4 / 6 ILE 3  96
LEU 3  32
VAL 3  42
ARG 3  39
 None
 1.27A 6f6jA-5udb3:
undetectable		 6f6jA-5udb3:
undetectable