SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5udh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 129
THR A 131
PRO A 127
 None
 0.83A 1a7yB-5udhA:
undetectable		 1a7yB-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.85A 1i3wG-5udhA:
undetectable		 1i3wG-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 129
THR A 131
PRO A 127
 None
 0.85A 1qfiB-5udhA:
undetectable		 1qfiB-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.80A 1unjF-5udhA:
undetectable		 1unjF-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.84A 1unjL-5udhA:
undetectable		 1unjL-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.86A 1unjX-5udhA:
undetectable		 1unjX-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.85A 1unmE-5udhA:
undetectable		 1unmE-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 129
THR A 131
PRO A 127
 None
 0.85A 209dC-5udhA:
undetectable		 209dC-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 CYH A 281
CYH A 297
HIS A 283
 ZN  A 603 (-2.2A)
ZN  A 603 (-2.2A)
None
 0.86A 2iwkA-5udhA:
undetectable		 2iwkA-5udhA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 CYH A 281
CYH A 297
HIS A 283
 ZN  A 603 (-2.2A)
ZN  A 603 (-2.2A)
None
 0.85A 2iwkB-5udhA:
undetectable		 2iwkB-5udhA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		4 / 6 TYR A 474
TYR A 481
TYR A 547
LEU A 482
 None
 1.20A 2w98A-5udhA:
undetectable
2w98B-5udhA:
undetectable		 2w98A-5udhA:
20.32
2w98B-5udhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.88A 316dC-5udhA:
undetectable		 316dC-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 CYH A 281
CYH A 297
HIS A 283
 ZN  A 603 (-2.2A)
ZN  A 603 (-2.2A)
None
 0.83A 3dtuB-5udhA:
undetectable		 3dtuB-5udhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 CYH A 281
CYH A 297
HIS A 283
 ZN  A 603 (-2.2A)
ZN  A 603 (-2.2A)
None
 0.80A 3dtuD-5udhA:
undetectable		 3dtuD-5udhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		5 / 12 CYH A 357
GLY A 356
ASN A 423
ASN A 358
GLY A 355
 None
 1.00A 3huoB-5udhA:
undetectable		 3huoB-5udhA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		4 / 5 GLY A 355
ASP A 354
ARG A 511
GLN A 440
 None
 1.35A 3qx3A-5udhA:
undetectable		 3qx3A-5udhA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
PRO A 127
THR A 129
 None
 0.88A 4hivD-5udhA:
undetectable		 4hivD-5udhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		5 / 12 LEU A 472
TYR A 476
HIS A 424
SER A 427
LEU A 465
 None
 1.50A 4yvxA-5udhA:
undetectable		 4yvxA-5udhA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 ARG A 271
PRO A 290
ASN A 306
 None
 0.96A 5jwaA-5udhA:
undetectable
5jwaH-5udhA:
undetectable		 5jwaA-5udhA:
21.21
5jwaH-5udhA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		5 / 11 ASN A 310
HIS A 312
TYR A 474
CYH A 304
LEU A 320
 None
ZN  A 604 (-3.2A)
None
ZN  A 604 (-2.3A)
None
 1.03A 5updA-5udhA:
undetectable		 5updA-5udhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		5 / 12 ASN A 310
HIS A 312
TYR A 474
CYH A 304
LEU A 320
 None
ZN  A 604 (-3.2A)
None
ZN  A 604 (-2.3A)
None
 1.06A 6a5kA-5udhA:
undetectable		 6a5kA-5udhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		5 / 12 ASN A 310
HIS A 312
TYR A 474
CYH A 304
LEU A 320
 None
ZN  A 604 (-3.2A)
None
ZN  A 604 (-2.3A)
None
 1.03A 6a5mA-5udhA:
undetectable		 6a5mA-5udhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		5 / 11 ASN A 310
HIS A 312
TYR A 474
CYH A 304
LEU A 320
 None
ZN  A 604 (-3.2A)
None
ZN  A 604 (-2.3A)
None
 1.04A 6cenA-5udhA:
undetectable		 6cenA-5udhA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		4 / 5 LEU A 216
LEU A 201
THR A 228
PRO A 127
 None
 0.99A 6ew0F-5udhA:
undetectable		 6ew0F-5udhA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens) 		3 / 3 THR A 131
GLU A 115
ASN A 121
 None
 0.89A 6nj9K-5udhA:
undetectable		 6nj9K-5udhA:
22.18