SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ue8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 8 VAL A 909
LEU A 897
PRO A 855
HIS A 836
 None
 1.03A 1jtvA-5ue8A:
undetectable		 1jtvA-5ue8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 ARG A 619
ALA A 614
ILE A 782
GLU A 784
 None
 1.06A 1oniA-5ue8A:
undetectable
1oniB-5ue8A:
undetectable		 1oniA-5ue8A:
9.05
1oniB-5ue8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 ARG A 619
ALA A 614
ILE A 782
GLU A 784
 None
 1.10A 1oniB-5ue8A:
undetectable
1oniC-5ue8A:
undetectable		 1oniB-5ue8A:
9.05
1oniC-5ue8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 ILE A 782
GLU A 784
ARG A 619
ALA A 614
 None
 1.03A 1oniD-5ue8A:
undetectable
1oniE-5ue8A:
undetectable		 1oniD-5ue8A:
9.05
1oniE-5ue8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 10 LEU A1209
VAL A1205
LEU A1275
GLN A1278
PHE A1234
 None
 1.21A 1rlbE-5ue8A:
undetectable		 1rlbE-5ue8A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 PHE A 936
TYR A 888
GLY A 942
LYS A 943
 None
 1.35A 2i30A-5ue8A:
2.6		 2i30A-5ue8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 PHE A 569
THR A 598
ARG A 596
LYS A 603
 None
 1.14A 2kotA-5ue8A:
undetectable		 2kotA-5ue8A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 GLY A 683
GLU A 622
ASP A 615
TYR A 559
 None
 1.34A 2yvlC-5ue8A:
2.9		 2yvlC-5ue8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		6 / 11 HIS A 814
LEU A 788
VAL A 817
GLY A 790
VAL A 825
ILE A 783
 None
 1.42A 2yy8A-5ue8A:
undetectable
2yy8B-5ue8A:
2.4		 2yy8A-5ue8A:
11.76
2yy8B-5ue8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A1017
TRP A1101
TYR A1021
 None
 0.88A 3aicA-5ue8A:
undetectable		 3aicA-5ue8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A1017
TRP A1101
TYR A1021
 None
 0.84A 3aicB-5ue8A:
undetectable		 3aicB-5ue8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A1017
TRP A1101
TYR A1021
 None
 0.88A 3aicE-5ue8A:
undetectable		 3aicE-5ue8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A1017
TRP A1101
TYR A1021
 None
 0.98A 3aicF-5ue8A:
undetectable		 3aicF-5ue8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A1017
TRP A1101
TYR A1021
 None
 0.87A 3aicG-5ue8A:
undetectable		 3aicG-5ue8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 LEU A1017
TRP A1101
TYR A1021
 None
 0.84A 3aicH-5ue8A:
undetectable		 3aicH-5ue8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 11 LEU A1209
ALA A1235
VAL A1205
LEU A1275
GLN A1278
 None
 1.21A 3bszE-5ue8A:
undetectable		 3bszE-5ue8A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 5 THR A 721
VAL A 718
GLY A 719
LYS A 720
 None
 1.15A 3elzA-5ue8A:
undetectable		 3elzA-5ue8A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 VAL A1162
LEU A1120
ILE A1226
ILE A1163
 None
 0.56A 3gcsA-5ue8A:
undetectable		 3gcsA-5ue8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 ASN A1371
ASP A1366
ARG A1401
 None
 0.89A 3k13A-5ue8A:
undetectable		 3k13A-5ue8A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 PHE A1025
TYR A1110
LEU A1017
 None
 0.78A 3keeB-5ue8A:
undetectable		 3keeB-5ue8A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 ILE A1216
HIS A1229
MET A1231
ARG A1233
 None
 1.43A 4acbB-5ue8A:
undetectable
4acbC-5ue8A:
undetectable		 4acbB-5ue8A:
19.90
4acbC-5ue8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 7 THR A 781
LEU A 788
VAL A 716
VAL A 753
 None
 0.93A 4cp4A-5ue8A:
undetectable		 4cp4A-5ue8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 9 THR A1298
LEU A1299
ALA A1235
LEU A1209
LEU A1291
 None
 1.45A 4ltwA-5ue8A:
undetectable		 4ltwA-5ue8A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		3 / 3 SER A1096
MET A1100
ASP A1011
 None
 0.84A 4mm4B-5ue8A:
undetectable		 4mm4B-5ue8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 CYH A1016
SER A 962
VAL A1099
MET A1100
LEU A 979
 None
 1.31A 4o8fB-5ue8A:
undetectable		 4o8fB-5ue8A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 LEU A1336
MET A1332
VAL A1360
ASN A1359
 None
 1.47A 5b8iB-5ue8A:
undetectable		 5b8iB-5ue8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 ALA A 689
VAL A 817
VAL A 718
HIS A 745
 None
 1.06A 5eckD-5ue8A:
undetectable		 5eckD-5ue8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 GLY A 594
HIS A 605
HIS A 567
CYH A 597
LEU A 612
 None
ZN  A1701 (-3.1A)
ZN  A1702 (-3.0A)
ZN  A1702 (-2.3A)
None
 1.27A 5lsuA-5ue8A:
undetectable		 5lsuA-5ue8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 LEU A 986
THR A 912
SER A 911
LEU A1083
LEU A 979
 None
 1.07A 5nfjB-5ue8A:
undetectable		 5nfjB-5ue8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		5 / 12 LEU A 986
THR A 912
SER A 911
LEU A1083
LEU A 979
 None
 1.07A 5nfjC-5ue8A:
undetectable		 5nfjC-5ue8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 VAL A1395
ILE A1325
GLU A1326
ARG A1401
 None
 0.85A 5z3jA-5ue8A:
undetectable		 5z3jA-5ue8A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 4 LEU A1361
ASP A1358
GLN A1362
VAL A1387
 None
 1.29A 6bzoF-5ue8A:
3.9		 6bzoF-5ue8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5ue8 PROTEIN UNC-13
HOMOLOG A
(Rattus
norvegicus) 		4 / 6 HIS A 836
TYR A 832
TYR A 866
GLN A 889
 None
 1.49A 6d8pA-5ue8A:
undetectable		 6d8pA-5ue8A:
22.31