SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 8 TRP H 103
GLY H 100
TYR H 100
HIS H  35
None
1.06A 1maaD-5uemH:
undetectable
1maaD-5uemH:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 4 THR H 107
GLN H 105
GLU H  23
ASP H  72
None
1.42A 1nw3A-5uemH:
undetectable
1nw3A-5uemH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)
5uem 354NC37 FAB HEAVY
CHAIN
354NC37 FAB LIGHT
CHAIN

(Homo
sapiens)
5 / 11 LEU L  28
ILE L   2
HIS H  35
ASP H  95
GLY H 100
None
1.10A 1zz1A-5uemL:
undetectable
1zz1A-5uemL:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)
5uem 354NC37 FAB HEAVY
CHAIN
354NC37 FAB LIGHT
CHAIN

(Homo
sapiens)
5 / 12 LEU L  28
ILE L   2
HIS H  35
ASP H  95
GLY H 100
None
1.12A 1zz1C-5uemL:
undetectable
1zz1C-5uemL:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 7 TRP H 103
GLY H 100
TYR H 100
HIS H  35
None
1.00A 2ackA-5uemH:
undetectable
2ackA-5uemH:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
5uem 354NC37 FAB LIGHT
CHAIN

(Homo
sapiens)
4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
None
0.86A 2aojA-5uemL:
undetectable
2aojA-5uemL:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5uem 354NC37 FAB HEAVY
CHAIN
354NC37 FAB LIGHT
CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 7 LYS L  39
GLN L  37
PHE L  36
LEU H  39
None
1.04A 2eimC-5uemL:
undetectable
2eimJ-5uemL:
undetectable
2eimC-5uemL:
undetectable
2eimJ-5uemL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 8 PHE H  29
ILE H  73
GLY H  55
GLY H  54
None
0.74A 2qx4A-5uemH:
undetectable
2qx4B-5uemH:
undetectable
2qx4A-5uemH:
16.07
2qx4B-5uemH:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 6 PHE H  29
ILE H  73
GLY H  55
GLY H  54
None
0.68A 2qx6A-5uemH:
undetectable
2qx6B-5uemH:
undetectable
2qx6A-5uemH:
16.07
2qx6B-5uemH:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
None
0.45A 3huoA-5uemH:
undetectable
3huoA-5uemH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 GLY H  55
GLY H  56
ASP H  31
VAL H 102
LEU H   4
None
0.99A 3m6wA-5uemH:
undetectable
3m6wA-5uemH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5uem 354NC37 FAB HEAVY
CHAIN
354NC37 FAB LIGHT
CHAIN

(Homo
sapiens;
Homo
sapiens)
4 / 8 SER H  93
GLU H  46
GLY L  94
LYS L   1
None
1.04A 4fgzA-5uemH:
undetectable
4fgzB-5uemH:
undetectable
4fgzA-5uemH:
undetectable
4fgzB-5uemH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.88A 4qvnH-5uemH:
undetectable
4qvnI-5uemH:
undetectable
4qvnH-5uemH:
15.81
4qvnI-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 10 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.88A 4qvnV-5uemH:
undetectable
4qvnW-5uemH:
undetectable
4qvnV-5uemH:
15.81
4qvnW-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 4qvpH-5uemH:
undetectable
4qvpI-5uemH:
undetectable
4qvpH-5uemH:
15.81
4qvpI-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 4qvpV-5uemH:
undetectable
4qvpW-5uemH:
undetectable
4qvpV-5uemH:
15.81
4qvpW-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.88A 4qvqH-5uemH:
undetectable
4qvqI-5uemH:
undetectable
4qvqH-5uemH:
15.81
4qvqI-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.87A 4qvqV-5uemH:
undetectable
4qvqW-5uemH:
undetectable
4qvqV-5uemH:
15.81
4qvqW-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.90A 4qvvH-5uemH:
undetectable
4qvvH-5uemH:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.90A 4qvvV-5uemH:
undetectable
4qvvV-5uemH:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.90A 4qvyH-5uemH:
undetectable
4qvyH-5uemH:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.90A 4qvyV-5uemH:
undetectable
4qvyW-5uemH:
undetectable
4qvyV-5uemH:
15.81
4qvyW-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 4qw0H-5uemH:
undetectable
4qw0I-5uemH:
undetectable
4qw0H-5uemH:
15.81
4qw0I-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 4qw0V-5uemH:
undetectable
4qw0W-5uemH:
undetectable
4qw0V-5uemH:
15.81
4qw0W-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 4qw1H-5uemH:
undetectable
4qw1I-5uemH:
undetectable
4qw1H-5uemH:
15.81
4qw1I-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 4qw1V-5uemH:
undetectable
4qw1W-5uemH:
undetectable
4qw1V-5uemH:
15.81
4qw1W-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 4qwuH-5uemH:
undetectable
4qwuI-5uemH:
undetectable
4qwuH-5uemH:
15.81
4qwuI-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 4qwuV-5uemH:
undetectable
4qwuW-5uemH:
undetectable
4qwuV-5uemH:
15.81
4qwuW-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
4 / 6 TYR H  33
HIS H  53
GLY H  55
ARG H  71
None
1.08A 4zbqA-5uemH:
undetectable
4zbqA-5uemH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.93A 5bxnH-5uemH:
undetectable
5bxnI-5uemH:
undetectable
5bxnH-5uemH:
16.81
5bxnI-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 5cz7V-5uemH:
undetectable
5cz7W-5uemH:
undetectable
5cz7V-5uemH:
15.81
5cz7W-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.88A 5d0xV-5uemH:
undetectable
5d0xV-5uemH:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 5l5fH-5uemH:
undetectable
5l5fI-5uemH:
undetectable
5l5fH-5uemH:
15.81
5l5fI-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.86A 5l5fV-5uemH:
undetectable
5l5fW-5uemH:
undetectable
5l5fV-5uemH:
15.81
5l5fW-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 5l66H-5uemH:
undetectable
5l66I-5uemH:
undetectable
5l66H-5uemH:
15.81
5l66I-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
0.89A 5l66V-5uemH:
undetectable
5l66W-5uemH:
undetectable
5l66V-5uemH:
15.81
5l66W-5uemH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5uem 354NC37 FAB HEAVY
CHAIN

(Homo
sapiens)
5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
None
1.04A 6hwdH-5uemH:
undetectable
6hwdI-5uemH:
undetectable
6hwdH-5uemH:
18.60
6hwdI-5uemH:
17.44