SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5uff RBC36
(Petromyzon
marinus) 		5 / 12 LEU A 102
LEU A  78
LEU A  54
LEU A  88
LEU A  85
 None
 1.06A 1sqnB-5uffA:
undetectable		 1sqnB-5uffA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5uff RBC36
(Petromyzon
marinus) 		5 / 9 LEU A 104
LEU A  88
VAL A  68
LEU A  75
PHE A  93
 None
 1.26A 1tbfA-5uffA:
undetectable		 1tbfA-5uffA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 5uff RBC36
(Petromyzon
marinus) 		4 / 8 LEU A  85
GLY A  86
LEU A  64
PRO A 113
 None
 0.90A 1ya4A-5uffA:
undetectable		 1ya4A-5uffA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5uff RBC36
(Petromyzon
marinus) 		4 / 7 LEU A  85
GLY A  86
LEU A  64
PRO A 113
 None
 0.93A 1ya4B-5uffA:
undetectable		 1ya4B-5uffA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5uff RBC36
(Petromyzon
marinus) 		4 / 8 GLY A  81
SER A  82
ASP A 152
ASP A 103
 None
8B7  A 300 ( 4.2A)
8B7  A 300 (-3.0A)
8B7  A 300 (-3.2A)
 0.73A 3pwwA-5uffA:
undetectable		 3pwwA-5uffA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5uff RBC36
(Petromyzon
marinus) 		4 / 5 ILE A  47
PRO A  48
SER A  24
GLY A  46
 None
 1.18A 3tkdB-5uffA:
undetectable		 3tkdB-5uffA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5uff RBC36
(Petromyzon
marinus) 		5 / 12 LEU A 170
ILE A 140
ALA A 215
ALA A 201
VAL A 194
 None
 1.15A 4hfpD-5uffA:
undetectable		 4hfpD-5uffA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uff RBC36
(Petromyzon
marinus) 		5 / 12 PHE A  93
ILE A  47
LEU A  64
LEU A  80
LEU A  56
 None
 1.32A 4xumA-5uffA:
undetectable		 4xumA-5uffA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5uff RBC36
(Petromyzon
marinus) 		5 / 12 LEU A 143
LEU A 109
PHE A 117
PHE A  93
LEU A  64
 None
 1.17A 5iepA-5uffA:
undetectable		 5iepA-5uffA:
18.98