SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ufh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 6 ARG A 206
GLY A 147
ASP A 148
TYR A 308
 GOL  A 401 (-2.7A)
None
None
None
 1.48A 1kf6M-5ufhA:
undetectable
1kf6N-5ufhA:
undetectable		 1kf6M-5ufhA:
20.72
1kf6N-5ufhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 8 SER A  73
ALA A  81
LEU A  67
ASP A 286
 None
None
None
GOL  A 401 ( 2.9A)
 1.13A 2bxkA-5ufhA:
undetectable		 2bxkA-5ufhA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 5 PRO A 161
ALA A 165
ASP A 148
ASP A 127
 NO3  A 402 (-4.4A)
None
None
NO3  A 410 (-3.6A)
 1.03A 2nyuB-5ufhA:
2.1		 2nyuB-5ufhA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 5 ILE A  69
LEU A  67
ASP A  82
ALA A  77
 None
 1.04A 2opxA-5ufhA:
3.2		 2opxA-5ufhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		5 / 9 LEU A 183
ALA A 186
MET A 261
MET A 166
ARG A 206
 None
None
None
None
GOL  A 401 (-2.7A)
 1.34A 2qo5A-5ufhA:
undetectable		 2qo5A-5ufhA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		5 / 9 ALA A  68
ALA A 119
GLY A 121
GLY A  66
ILE A  96
 None
 1.31A 2v7bA-5ufhA:
5.0		 2v7bA-5ufhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		5 / 9 ALA A  68
ALA A 119
GLY A 121
GLY A  66
ILE A  96
 None
 1.29A 2v7bB-5ufhA:
4.9		 2v7bB-5ufhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 4 SER A 236
GLY A 237
GLY A 230
GLY A 185
 None
None
NO3  A 417 (-4.1A)
None
 0.88A 3bogB-5ufhA:
undetectable
3bogD-5ufhA:
undetectable		 3bogB-5ufhA:
undetectable
3bogD-5ufhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 7 PRO A 303
ILE A 305
VAL A 158
SER A 332
 None
None
None
NO3  A 408 ( 4.9A)
 0.99A 4a3uB-5ufhA:
undetectable		 4a3uB-5ufhA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 5 LEU A 316
ASP A 120
TRP A 122
ILE A  96
 None
 1.32A 4mwrA-5ufhA:
undetectable		 4mwrA-5ufhA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		4 / 7 LEU A 257
THR A 170
LEU A 226
ILE A 181
 None
 0.84A 4ubsA-5ufhA:
undetectable		 4ubsA-5ufhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		5 / 11 GLY A 188
SER A 228
ALA A 240
LEU A 257
MET A 211
 None
 0.82A 4xumB-5ufhA:
undetectable		 4xumB-5ufhA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		3 / 3 VAL A 337
THR A 300
ARG A 339
 None
 0.74A 5b2sB-5ufhA:
undetectable		 5b2sB-5ufhA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 5ufh LACI-TYPE
TRANSCRIPTIONAL
REGULATOR
(Bifidobacterium
animalis) 		3 / 3 VAL A 337
THR A 300
ARG A 339
 None
 0.75A 5b2tB-5ufhA:
undetectable		 5b2tB-5ufhA:
13.96