SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ufm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.82A 1c6yB-5ufmA:
undetectable		 1c6yB-5ufmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 TYR A 149
GLY A 136
TYR A  28
PHE A  36
PHE A 168
 None
AZ8  A 302 ( 3.5A)
None
SAH  A 301 (-3.4A)
AZ8  A 302 (-4.8A)
 1.24A 1fdsA-5ufmA:
6.2		 1fdsA-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.75A 1hsgB-5ufmA:
undetectable		 1hsgB-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 LEU A  60
SER A  57
ASP A  80
PHE A 163
 None
None
SAH  A 301 (-4.0A)
None
 1.19A 1ismB-5ufmA:
undetectable		 1ismB-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.80A 1k6cB-5ufmA:
undetectable		 1k6cB-5ufmA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ALA A  73
LEU A  71
VAL A  91
LEU A  64
PHE A 163
 None
 0.91A 1s9pB-5ufmA:
undetectable		 1s9pB-5ufmA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.81A 1sdtB-5ufmA:
undetectable		 1sdtB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 11 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.81A 1sdvB-5ufmA:
undetectable		 1sdvB-5ufmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.01A 1zzrA-5ufmA:
undetectable
1zzrB-5ufmA:
undetectable		 1zzrA-5ufmA:
10.95
1zzrB-5ufmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.07A 1zzuA-5ufmA:
undetectable
1zzuB-5ufmA:
undetectable		 1zzuA-5ufmA:
10.95
1zzuB-5ufmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.04A 1zzuA-5ufmA:
undetectable
1zzuB-5ufmA:
undetectable		 1zzuA-5ufmA:
10.95
1zzuB-5ufmA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.79A 2avoB-5ufmA:
undetectable		 2avoB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.79A 2bpxB-5ufmA:
undetectable		 2bpxB-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.80A 2f80A-5ufmA:
undetectable		 2f80A-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.79A 2f81A-5ufmA:
undetectable		 2f81A-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.81A 2f81B-5ufmA:
undetectable		 2f81B-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.83A 2f8gA-5ufmA:
undetectable		 2f8gA-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.82A 2ienB-5ufmA:
undetectable		 2ienB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 4 ASP A  95
ASP A  72
ASP A  45
GLY A 136
 SAH  A 301 (-2.7A)
None
None
AZ8  A 302 ( 3.5A)
 1.39A 2igtC-5ufmA:
13.9		 2igtC-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.81A 2pymA-5ufmA:
undetectable		 2pymA-5ufmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.87A 2q5kB-5ufmA:
undetectable		 2q5kB-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.84A 3cywA-5ufmA:
undetectable		 3cywA-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.81A 3cywB-5ufmA:
undetectable		 3cywB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.03A 3dqrA-5ufmA:
undetectable
3dqrB-5ufmA:
undetectable		 3dqrA-5ufmA:
10.90
3dqrB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 9 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.91A 3ektA-5ufmA:
undetectable		 3ektA-5ufmA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.84A 3ekvA-5ufmA:
undetectable		 3ekvA-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 11 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.84A 3ekxA-5ufmA:
undetectable		 3ekxA-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.09A 3jx2A-5ufmA:
undetectable
3jx2B-5ufmA:
undetectable		 3jx2A-5ufmA:
10.90
3jx2B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.07A 3jx2A-5ufmA:
undetectable
3jx2B-5ufmA:
undetectable		 3jx2A-5ufmA:
10.90
3jx2B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.08A 3jx3A-5ufmA:
undetectable
3jx3B-5ufmA:
undetectable		 3jx3A-5ufmA:
10.90
3jx3B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.07A 3jx3A-5ufmA:
undetectable
3jx3B-5ufmA:
undetectable		 3jx3A-5ufmA:
10.90
3jx3B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.07A 3jx6A-5ufmA:
0.9
3jx6B-5ufmA:
0.9		 3jx6A-5ufmA:
10.90
3jx6B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		3 / 3 ARG A  79
ASP A  95
GLN A 141
 SAH  A 301 (-2.9A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
 0.92A 3lcvB-5ufmA:
10.8		 3lcvB-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.83A 3lzuA-5ufmA:
undetectable		 3lzuA-5ufmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.07A 3nlpA-5ufmA:
undetectable
3nlpB-5ufmA:
undetectable		 3nlpA-5ufmA:
10.90
3nlpB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.08A 3nlpA-5ufmA:
undetectable
3nlpB-5ufmA:
undetectable		 3nlpA-5ufmA:
10.90
3nlpB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 8 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.07A 3nlqA-5ufmA:
undetectable
3nlqB-5ufmA:
undetectable		 3nlqA-5ufmA:
10.90
3nlqB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.03A 3nlrA-5ufmA:
undetectable
3nlrB-5ufmA:
0.9		 3nlrA-5ufmA:
10.90
3nlrB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 8 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.05A 3nlrA-5ufmA:
undetectable
3nlrB-5ufmA:
0.9		 3nlrA-5ufmA:
10.90
3nlrB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.88A 3oxcA-5ufmA:
undetectable		 3oxcA-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.84A 3oxwA-5ufmA:
undetectable		 3oxwA-5ufmA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 ASP A  95
GLY A  76
ASP A  72
VAL A 120
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
 0.73A 3t3cA-5ufmA:
undetectable		 3t3cA-5ufmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.05A 4cx3A-5ufmA:
undetectable
4cx3B-5ufmA:
undetectable		 4cx3A-5ufmA:
10.90
4cx3B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.03A 4cx3A-5ufmA:
undetectable
4cx3B-5ufmA:
undetectable		 4cx3A-5ufmA:
10.90
4cx3B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.03A 4cx4A-5ufmA:
0.9
4cx4B-5ufmA:
undetectable		 4cx4A-5ufmA:
10.90
4cx4B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.04A 4cx4A-5ufmA:
0.9
4cx4B-5ufmA:
undetectable		 4cx4A-5ufmA:
10.90
4cx4B-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 11 ASP A  72
GLY A  74
GLY A  76
ASP A  95
ASN A 135
 None
SAH  A 301 (-3.6A)
SAH  A 301 (-3.6A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.9A)
 0.78A 4dcmA-5ufmA:
14.3		 4dcmA-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 9 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.90A 4dqcB-5ufmA:
undetectable		 4dqcB-5ufmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.85A 4ll3B-5ufmA:
undetectable		 4ll3B-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.82A 4ll3A-5ufmA:
undetectable		 4ll3A-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 11 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.86A 4njvB-5ufmA:
undetectable		 4njvB-5ufmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 6 LEU A  60
LEU A  71
VAL A  70
PHE A 163
 None
 1.10A 4uswA-5ufmA:
undetectable		 4uswA-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 11 LEU A 138
LEU A 196
ALA A 151
LEU A 150
TYR A 149
 None
 1.18A 4wg0B-5ufmA:
undetectable
4wg0C-5ufmA:
undetectable
4wg0D-5ufmA:
undetectable		 4wg0B-5ufmA:
undetectable
4wg0C-5ufmA:
undetectable
4wg0D-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 11 LEU A 138
LEU A 196
ALA A 151
LEU A 150
TYR A 149
 None
 1.17A 4wg0D-5ufmA:
undetectable
4wg0E-5ufmA:
undetectable
4wg0F-5ufmA:
undetectable		 4wg0D-5ufmA:
undetectable
4wg0E-5ufmA:
undetectable
4wg0F-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 6 VAL A  94
ARG A 128
VAL A  91
PHE A 129
 None
 1.03A 5addA-5ufmA:
undetectable
5addB-5ufmA:
undetectable		 5addA-5ufmA:
10.90
5addB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 7 PHE A 129
VAL A  94
ARG A 128
VAL A  91
 None
 1.03A 5addA-5ufmA:
undetectable
5addB-5ufmA:
undetectable		 5addA-5ufmA:
10.90
5addB-5ufmA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 6 LEU A 133
LEU A 157
PHE A  84
LEU A  64
 None
 0.94A 5gs4A-5ufmA:
undetectable		 5gs4A-5ufmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		4 / 5 LEU A 133
LEU A 157
PHE A  84
LEU A  64
 None
 0.99A 5gtrA-5ufmA:
undetectable		 5gtrA-5ufmA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		3 / 3 HIS A 139
SER A 166
ARG A 212
 AZ8  A 302 (-4.5A)
None
AZ8  A 302 (-3.9A)
 0.65A 5u63A-5ufmA:
2.4		 5u63A-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 GLY A  74
GLY A  76
ASP A  95
VAL A 120
HIS A 140
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.6A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.1A)
AZ8  A 302 (-4.0A)
 0.62A 5wy0A-5ufmA:
13.7		 5wy0A-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.89A 6dj1B-5ufmA:
undetectable		 6dj1B-5ufmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 5ufm METHYLTRANSFERASE
DOMAIN PROTEIN
(Burkholderia
thailandensis) 		5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
 SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
 0.90A 6dj2B-5ufmA:
undetectable		 6dj2B-5ufmA:
17.98