SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ug1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 446
ILE A 590
TYR A 586
ILE A 456
 None
 0.98A 1oniD-5ug1A:
undetectable
1oniF-5ug1A:
undetectable		 1oniD-5ug1A:
22.87
1oniF-5ug1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUG_A_HLTA149_1
(CALMODULIN)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 MET A 471
LEU A 472
MET A 513
LYS A 505
 None
 1.35A 2kugA-5ug1A:
undetectable		 2kugA-5ug1A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.20A 2y69C-5ug1A:
undetectable
2y69N-5ug1A:
undetectable
2y69P-5ug1A:
undetectable		 2y69C-5ug1A:
17.49
2y69N-5ug1A:
15.92
2y69P-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 588
THR A 589
TYR A 586
LEU A 451
 None
 1.16A 3ablA-5ug1A:
undetectable
3ablC-5ug1A:
undetectable
3ablP-5ug1A:
undetectable		 3ablA-5ug1A:
15.92
3ablC-5ug1A:
17.49
3ablP-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.17A 3ablC-5ug1A:
undetectable
3ablN-5ug1A:
undetectable
3ablP-5ug1A:
undetectable		 3ablC-5ug1A:
17.49
3ablN-5ug1A:
15.92
3ablP-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 588
THR A 589
TYR A 586
LEU A 451
 None
 1.19A 3abmA-5ug1A:
undetectable
3abmC-5ug1A:
undetectable
3abmP-5ug1A:
undetectable		 3abmA-5ug1A:
15.92
3abmC-5ug1A:
17.49
3abmP-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A 572
ALA A 583
ALA A 587
LEU A 434
 None
 1.02A 3l4dD-5ug1A:
undetectable		 3l4dD-5ug1A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 594
GLY A 436
ILE A 435
ILE A 514
ILE A 590
 None
 0.75A 3s45B-5ug1A:
undetectable		 3s45B-5ug1A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 11 ARG A 539
ASP A 498
ILE A 530
PRO A 518
THR A 517
 None
 1.09A 3spkA-5ug1A:
undetectable		 3spkA-5ug1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A 482
VAL A 602
HIS A 512
 None
 1.14A 3tj7A-5ug1A:
undetectable		 3tj7A-5ug1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 TRP A 500
LEU A 515
LEU A 507
ILE A 548
TYR A 547
 None
 1.34A 4a79A-5ug1A:
undetectable		 4a79A-5ug1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 TRP A 500
LEU A 515
LEU A 507
ILE A 548
TYR A 547
 None
 1.30A 4a79B-5ug1A:
undetectable		 4a79B-5ug1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A 568
ASP A 437
GLU A 520
GLU A 532
TYR A 586
 None
03S  A 701 (-4.0A)
None
None
None
 1.45A 4dfuA-5ug1A:
undetectable		 4dfuA-5ug1A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 TYR A 586
THR A 517
VAL A 556
ILE A 590
 None
 1.13A 4jx1F-5ug1A:
undetectable		 4jx1F-5ug1A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.18A 5iy5C-5ug1A:
undetectable
5iy5N-5ug1A:
undetectable
5iy5P-5ug1A:
undetectable		 5iy5C-5ug1A:
17.62
5iy5N-5ug1A:
15.92
5iy5P-5ug1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 515
LEU A 434
ALA A 535
ALA A 593
LEU A 594
 None
 1.06A 5jw1B-5ug1A:
undetectable		 5jw1B-5ug1A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 588
THR A 589
TYR A 586
LEU A 451
 None
 1.20A 5w97A-5ug1A:
undetectable
5w97C-5ug1A:
undetectable
5w97c-5ug1A:
undetectable		 5w97A-5ug1A:
15.92
5w97C-5ug1A:
17.49
5w97c-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.20A 5w97C-5ug1A:
undetectable
5w97a-5ug1A:
undetectable
5w97c-5ug1A:
undetectable		 5w97C-5ug1A:
17.49
5w97a-5ug1A:
15.92
5w97c-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.18A 5wauC-5ug1A:
undetectable
5waua-5ug1A:
undetectable
5wauc-5ug1A:
undetectable		 5wauC-5ug1A:
17.49
5waua-5ug1A:
15.92
5wauc-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 588
THR A 589
TYR A 586
LEU A 451
 None
 1.19A 5x1bA-5ug1A:
undetectable
5x1bC-5ug1A:
undetectable
5x1bP-5ug1A:
undetectable		 5x1bA-5ug1A:
15.92
5x1bC-5ug1A:
17.49
5x1bP-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 588
THR A 589
TYR A 586
LEU A 451
 None
 1.17A 5x1fA-5ug1A:
undetectable
5x1fC-5ug1A:
undetectable
5x1fP-5ug1A:
undetectable		 5x1fA-5ug1A:
15.92
5x1fC-5ug1A:
17.49
5x1fP-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.17A 5xdxC-5ug1A:
undetectable
5xdxN-5ug1A:
undetectable
5xdxP-5ug1A:
undetectable		 5xdxC-5ug1A:
17.56
5xdxN-5ug1A:
15.92
5xdxP-5ug1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.22A 5z84C-5ug1A:
undetectable
5z84N-5ug1A:
undetectable
5z84P-5ug1A:
undetectable		 5z84C-5ug1A:
17.49
5z84N-5ug1A:
15.92
5z84P-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.22A 5z85C-5ug1A:
undetectable
5z85N-5ug1A:
undetectable
5z85P-5ug1A:
undetectable		 5z85C-5ug1A:
17.49
5z85N-5ug1A:
15.92
5z85P-5ug1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 507
THR A 432
ALA A 542
LEU A 594
LEU A 515
 None
None
NA  A 702 (-4.9A)
None
None
 1.13A 6ie8A-5ug1A:
undetectable		 6ie8A-5ug1A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ug1 ACYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A 451
ASP A 588
THR A 589
TYR A 586
 None
 1.17A 6nknC-5ug1A:
undetectable
6nknN-5ug1A:
undetectable
6nknP-5ug1A:
undetectable		 6nknC-5ug1A:
17.49
6nknN-5ug1A:
15.92
6nknP-5ug1A:
17.49