SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ug4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q0Y_H_MOIH401_1 (FAB 9B1, HEAVY CHAIN FAB 9B1, LIGHT CHAIN)	5ug4	SPERMIDINE N(1)-ACETYLTRANSFERA SE (Vibrio cholerae)	4 / 7	GLU A 55 ILE A 74 TRP A 31 LEU A 45	None	1.16A	1q0yH-5ug4A: undetectable 1q0yL-5ug4A: undetectable	1q0yH-5ug4A: 18.18 1q0yL-5ug4A: 18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MJ8_A_SPMA202_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	5ug4	SPERMIDINE N(1)-ACETYLTRANSFERA SE (Vibrio cholerae)	6 / 8	ILE A 74 GLU A 75 GLU A 84 GLN A 86 ILE A 87 LEU A 121	None CA A 201 (-3.5A) None None None None	0.45A	4mj8A-5ug4A: 25.8	4mj8A-5ug4A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_A_SAMA602_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	5ug4	SPERMIDINE N(1)-ACETYLTRANSFERA SE (Vibrio cholerae)	5 / 12	ALA A 90 ILE A 88 GLY A 69 ASN A 20 PHE A 17	None	1.08A	4obwA-5ug4A: 3.9	4obwA-5ug4A: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5PHH_A_LDPA414_1 (LYSINE-SPECIFIC DEMETHYLASE 4D)	5ug4	SPERMIDINE N(1)-ACETYLTRANSFERA SE (Vibrio cholerae)	4 / 6	ARG A 56 ALA A 9 LEU A 10 TYR A 46	None	1.07A	5phhA-5ug4A: undetectable	5phhA-5ug4A: 18.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q0Y_H_MOIH401_1","FAB 9B1, HEAVY CHAIN;FAB 9B1, LIGHT CHAIN","5ug4","SPERMIDINE N(1)-ACETYLTRANSFERASE","Vibrio cholerae",4,"GLU A  55;ILE A  74;TRP A  31;LEU A  45","None","1.16A","1q0yH-5ug4A:undetectable;1q0yL-5ug4A:undetectable","1q0yH-5ug4A:18.18;1q0yL-5ug4A:18.35"],["4MJ8_A_SPMA202_1","SPERMIDINE N1-ACETYLTRANSFERASE","5ug4","SPERMIDINE N(1)-ACETYLTRANSFERASE","Vibrio cholerae",6,"ILE A  74;GLU A  75;GLU A  84;GLN A  86;ILE A  87;LEU A 121","None; CA A 201 (-3.5A);None;None;None;None","0.45A","4mj8A-5ug4A:25.8","4mj8A-5ug4A:100.00"],["4OBW_A_SAMA602_0","2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL","5ug4","SPERMIDINE N(1)-ACETYLTRANSFERASE","Vibrio cholerae",5,"ALA A  90;ILE A  88;GLY A  69;ASN A  20;PHE A  17","None","1.08A","4obwA-5ug4A:3.9","4obwA-5ug4A:20.82"],["5PHH_A_LDPA414_1","LYSINE-SPECIFIC DEMETHYLASE 4D","5ug4","SPERMIDINE N(1)-ACETYLTRANSFERASE","Vibrio cholerae",4,"ARG A  56;ALA A   9;LEU A  10;TYR A  46","None","1.07A","5phhA-5ug4A:undetectable","5phhA-5ug4A:18.46"]]