SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ugw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens) 		4 / 8 LYS A1106
SER A1037
ASP A1038
GLU A1068
 None
 1.11A 1knyA-5ugwA:
2.1
1knyB-5ugwA:
2.4		 1knyA-5ugwA:
23.31
1knyB-5ugwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens) 		4 / 7 HIS A1013
THR A1088
TYR A1089
LEU A1092
 None
 0.76A 1qzrA-5ugwA:
undetectable		 1qzrA-5ugwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens) 		4 / 7 HIS A1013
THR A1088
TYR A1089
LEU A1092
 None
 0.78A 1qzrB-5ugwA:
undetectable		 1qzrB-5ugwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens) 		3 / 3 ARG A 972
TYR A1010
LYS A1081
 None
 0.87A 1uujB-5ugwA:
undetectable		 1uujB-5ugwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ugw TELOMERASE REVERSE
TRANSCRIPTASE
(Homo
sapiens) 		4 / 6 VAL A1070
LEU A1065
CYH A1043
LEU A 987
 None
 1.19A 5hrqB-5ugwA:
undetectable
5hrqI-5ugwA:
undetectable
5hrqJ-5ugwA:
undetectable		 5hrqB-5ugwA:
12.65
5hrqI-5ugwA:
8.86
5hrqJ-5ugwA:
12.65